Low-dose immunosuppression in a rat hind-limb transplantation model

Transplant International

Volumn 16, Issue 12, 2003, Pages 835-842

  Perez Abadia, Gustavo ^a   Laurentin Perez, Luis ^a   Gorantla, Vijay S ^a   Francois, Cedric G ^a   Vossen, Marieke ^a   Brouha, Pascal C R ^a   Orhun, Haldun I ^a   Anderson, Gary L ^a   Maldonado, Claudio ^a   Pidwell, Diane J ^b   Breidenbach, Warren C ^c   Barker, John H ^a  

^a University of Louisville School of Medicine   (United States)

^b JEWISH HOSPITAL   (United States)

^c CHRISTINE M KLEINERT INSTITUTE FOR HAND AND MICROSURGERY   (United States)

Author keywords

Combination therapy; Composite tissue allografts; Mycophenolate mofetil; Rats; Tacrolimus

Indexed keywords

CORTICOSTEROID; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOPSY; COMPOSITE GRAFT; CONTROLLED STUDY; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HINDLIMB; IMMUNOSUPPRESSIVE TREATMENT; LOW DRUG DOSE; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE TRANSPLANTATION;

EID: 0346257963     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00147-003-0576-4     Document Type: Article

References (39)

1. Allison AC, Almquist SJ, Muller CD, Eugui EM (1991) In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443. Transplant Proc 23 [Suppl 2]:10-14
2. Anstead GM (1998) Steroids, retinoids, and wound healing. Adv Wound Care 11:277-285
3. Arai K, Hotokebuchi T, Miyahara H, Arita C, Mohtai M, Sugioka Y, Kaibara N (1989) Limb allografts in rats immunosuppressed with FK506. I. Reversal of rejection and indefinite survival. Transplantation 48:782-786
4. Beck Y, Akiyama N (1989) Effect of FK-506 and cyclosporine on human lymphocyte responses in vitro. Transplant Proc 21:3464-3467
5. Behrend M (2001) Adverse gastrointestinal effects of mycophenolate mofetil: aetiology, incidence and management. Drug Saf 24:645-663
6. Benhaim P, Anthony JP, Lin LY, McCalmont TH, Mathes SJ (1993) A long-term study of allogeneic rat hind limb transplants immunosuppressed with RS-61443. Transplantation 56:911-917
7. Benhaim P, Anthony JP, Ferreira L, Borsanyi JP, Mathes SJ (1996) Use of combination of low-dose cyclosporine and RS-61443 in a rat hind limb model of composite tissue allotransplantation. Transplantation 61:527-532
8. Black KS, Hewitt CW, Fraser LA, Howard EB, Martin DC, Achauer BM, Furnas DW (1985) Composite tissue (limb) allografts in rats. II. Indefinite survival using low-dose cyclosporine. Transplantation 39:365-368
9. Black KS, Hewitt CW, Hwang JS, Borger RW, Achauer BM (1988) Dose response of cyclosporine-treated composite tissue allografts in a strong histoincompatible rat model. Transplant Proc 20 [Suppl 2]:266-268
10. Buttemeyer R, Jones NF, Min Z, Rao UR (1996) Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-606 and cyclosporine. Plast Reconstr Surg 97:139-148
11. Chiba K, Hoshino Y, Suzuki C, Masubuchi Y, Yanagawa Y, Ohtsuki M, Sasaki S, Fujita T (1996) FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats. Transplant Proc 28:1056-1059
12. Clipstone NA, Crabtree GR (1993) Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. Ann N Y Acad Sci 696:20-30
13. Dubernard JM, Owen ER, Lanzetta M, Hakim N (2001) What is happening with hand transplants. Lancet 357:1711-1712
14. Eugui EM, Mirkovich A, Allison AC (1991) Lymphocyte-selective antiproliferative and immunosuppressive activity of mycophenolic acid and its morpholinoethyl ester (RS-61443) in rodents. Transplant Proc 23 [Suppl 2]:15-18
15. Fealy MJ, Umansky WS, Bickel KD, Nino JJ, Morris RE, Press BH (1994) Efficacy of rapamycin and FK506 in prolonging rat hind limb allograft survival. Ann Surg 219:88-93
16. Francois CG, Breidenbach WC, Maldonado C, Kakoulidis TP, Hodges A, Dubernard JM, Owen E, Pei G, Ren X, Barker JH (2000) Hand transplantation: comparisons and observations of the first four clinical cases. Microsurgery 20:360-371
17. Fritz WD, Swartz WM, Rose S, Futrell JW, Klein E (1984) Limb allografts in rats immunosuppressed with cyclosporin A. Ann Surg 199:211-215
18. Gorantla VS, Barker JH, Jones JW, Prabhune KA, Maldonado C, Granger DK (2000) Immunosuppressive agents in transplantation: mechanisms of action and current anti-rejection strategies. Microsurgery 20:420-429
19. Hewitt CW, Black KS, Fraser LA, Howard EB, Martin DC, Achauer BM, Furnas DW (1985) Composite tissue (limb) allografts in rats. I. Dose-dependent increase in survival with cyclosporine. Transplantation 39:360-364
20. Hotokebuchi T, Arai K, Takagishi K, Arita C, Sugioka Y, Kaibara N (1989) Limb allografts in rats immunosuppressed with cyclosporine: as a whole-joint allograft. Plast Reconstr Surg 83:1027-1036
21. Ildstad ST, Sachs DH (1984) Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 307:168-170
22. Ivashkiv LB (2000) Jak-STAT signaling pathways in cells of the immune system. Rev Immunogenet 2:220-230
23. Janczewska S, Ziolkowska A, Durlik M, Olszewski WL, Lukomska B (1999) Fast lymphoid reconstitution after vascularized bone marrow transplantation in lethally irradiated rats. Transplantation 68:201-209
24. Jones JW, Gruber SA, Barker JH, Breidenbach WC (2000) Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. N Engl J Med 343:468-473
25. Kibbler CC (1999) Infections in solid organ transplant recipients. Curr Top Pathol 92:19-35
26. Lance EM, Inglis AE, Figarola F, Veith FJ (1971) Transplantation of the canine hind limb. Surgical technique and methods of immunosuppression for allotransplantation. A preliminary report. J Bone Joint Surg Am 53:1137-1149
27. Morris RE, Hoyt EG, Murphy MP, Eugui EM, Allison AC (1990) Mycophenolic acid morpholinoethyl ester (RS-61443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition. Transplant Proc 22:1659-1662
28. Morris RE, Wu J, Shorthouse R (1990) A study of the contrasting effects of cyclosporine, FK506, and rapamycin on the suppression of allograft rejection. Transplant Proc 22:1638-1641
29. Morris RE, Wu J, Shorthouse R (1990) Comparative immunopharmacologic effects of FK506 and CyA in in vivo models of organ transplantation. Transplant Proc 22:110-112
30. Muramatsu K, Doi K, Akino T, Shigetomi M, Kawai S (1997) Longer survival of rat limb allograft. Combined immunosuppression of FK-506 and 15-deoxyspergualin. Acta Orthop Scand 68:581-585
31. Muramatsu K, Doi K, Shigetomi M, Kido K, Kawai S (1998) A new immunosuppressant, FTY720, prolongs limb allograft survival in rats. Ann Plast Surg 40:160-165
32. Pei G, Gu L, Yu L (2000) A preliminary report of two cases of human hand allograft (in Chinese). Zhonghua Yi Xue Za Zhi 80:417-421
33. Prabhune KA, Gorantla VS, Maldonado C, Perez-Abadia G, Barker JH, Ildstad ST (2000) Mixed allogeneic chimerism and tolerance to composite tissue allografts. Microsurgery 20:441-447
34. Press BH, Sibley RK, Shons AR (1986) Limb allotransplantation in the rat: extended survival and return of nerve function with continuous cyclosporine/prednisone immunosuppression. Ann Plast Surg 16:313-321
35. Talmor M, Steinman RM, Codner MA, Chen M, Harper AD, Witmer-Pack MD, Hoffman LA (1995) Bone marrow-derived chimerism in non-irradiated, cyclosporine-treated rats receiving microvascularized limb transplants: evidence for donor-derived dendritic cells in recipient lymphoid tissues. Immunology 86:448-455
36. Tavassoli M (1992) The role of conditioning regimens in homing of transplanted hemopoietic cells. Bone Marrow Transplant 10:15-17
37. Weigao C (1996) Limb allograft in rats: studies on optimal maintenance dose of FK506 and development of graft-versus-host disease (GVHD) (in Japanese). Fukuoka Igaku Zasshi 87:197-205
38. Woo J, Thomson AW, Ildstad ST (1995) Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. Transpl Immunol 3:86-90
39. Zdichavsky M, Jones JW, Ustuner ET, Ren X, Edelstein J, Maldonado C, Breidenbach WC, Gruber SA, Ray M, Barker JH (1999) Scoring of skin rejection in a swine composite tissue allograft model. J Surg Res 85:1-8