메뉴 건너뛰기




Volumn 1556, Issue , 2014, Pages 10-18

Levetiracetam increases neonatal hypoxic-ischemic brain injury under normothermic, but not hypothermic conditions

Author keywords

Brain; Hypothermia; Hypoxic ischemic brain injury; Levetiracetam; Neurotoxic; Newborn

Indexed keywords

ETIRACETAM; GLUCOSE; OXYGEN;

EID: 84895922493     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.01.034     Document Type: Article
Times cited : (24)

References (38)
  • 1
    • 0025873453 scopus 로고
    • Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits
    • A.J. Baker et al. Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits Stroke 22 1991 666 673
    • (1991) Stroke , vol.22 , pp. 666-673
    • Baker, A.J.1
  • 2
  • 3
    • 0037069448 scopus 로고    scopus 로고
    • Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
    • P. Bittigau et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain Proc. Natl. Acad. Sci. USA 99 2002 15089 15094
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15089-15094
    • Bittigau, P.1
  • 4
    • 84859924291 scopus 로고    scopus 로고
    • Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury
    • Y. Carlsson et al. Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury Pediatr. Res. 71 2012 566 572
    • (2012) Pediatr. Res. , vol.71 , pp. 566-572
    • Carlsson, Y.1
  • 5
    • 34247145481 scopus 로고    scopus 로고
    • Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam
    • I. Carunchio et al. Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam Epilepsia 48 2007 654 662
    • (2007) Epilepsia , vol.48 , pp. 654-662
    • Carunchio, I.1
  • 6
    • 0025948834 scopus 로고
    • GABA: An excitatory transmitter in early postnatal life
    • E. Cherubini et al. GABA: an excitatory transmitter in early postnatal life Trends Neurosci. 14 1991 515 519
    • (1991) Trends Neurosci. , vol.14 , pp. 515-519
    • Cherubini, E.1
  • 7
    • 33646701918 scopus 로고    scopus 로고
    • Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia
    • C. Costa et al. Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia Stroke 37 2006 1319 1326
    • (2006) Stroke , vol.37 , pp. 1319-1326
    • Costa, C.1
  • 8
    • 0038054471 scopus 로고    scopus 로고
    • Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human
    • A. Craig et al. Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human Exp. Neurol. 181 2003 231 240
    • (2003) Exp. Neurol. , vol.181 , pp. 231-240
    • Craig, A.1
  • 9
    • 77955325929 scopus 로고    scopus 로고
    • Alterations of intracerebral gamma-aminobutyric acid (GABA) levels by titration with levetiracetam in patients with focal epilepsies
    • M.T. Doelken et al. Alterations of intracerebral gamma-aminobutyric acid (GABA) levels by titration with levetiracetam in patients with focal epilepsies Epilepsia 51 2010 1477 1482
    • (2010) Epilepsia , vol.51 , pp. 1477-1482
    • Doelken, M.T.1
  • 10
    • 77149149663 scopus 로고    scopus 로고
    • Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: Synthesis and meta-analysis of trial data
    • A.D. Edwards et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data Br. Med. J. 340 2010 c363
    • (2010) Br. Med. J. , vol.340 , pp. 363
    • Edwards, A.D.1
  • 11
    • 39549110817 scopus 로고    scopus 로고
    • Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: Role of GABA(A) receptors
    • A.S. Galanopoulou Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors J. Neurosci. 28 2008 1557 1567
    • (2008) J. Neurosci. , vol.28 , pp. 1557-1567
    • Galanopoulou, A.S.1
  • 12
    • 0035907025 scopus 로고    scopus 로고
    • GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition
    • K. Ganguly et al. GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition Cell 105 2001 521 532
    • (2001) Cell , vol.105 , pp. 521-532
    • Ganguly, K.1
  • 13
    • 4444383142 scopus 로고    scopus 로고
    • PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury
    • H. Hagberg et al. PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury J. Neurochem. 90 2004 1068 1075
    • (2004) J. Neurochem. , vol.90 , pp. 1068-1075
    • Hagberg, H.1
  • 14
    • 0034922707 scopus 로고    scopus 로고
    • Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia
    • E. Hanon, and H. Klitgaard Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia Seizure 10 2001 287 293
    • (2001) Seizure , vol.10 , pp. 287-293
    • Hanon, E.1    Klitgaard, H.2
  • 15
    • 70450207813 scopus 로고    scopus 로고
    • The long-term effects of neonatal seizures
    • (vii-viii)
    • G.L. Holmes The long-term effects of neonatal seizures Clin. Perinatol. 36 2009 901 914 (vii-viii)
    • (2009) Clin. Perinatol. , vol.36 , pp. 901-914
    • Holmes, G.L.1
  • 16
    • 40549105461 scopus 로고    scopus 로고
    • Dextromethorphan is protective against sensitized N-methyl-d-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain
    • M. Keller et al. Dextromethorphan is protective against sensitized N-methyl-d-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain Eur. J. Neurosci. 27 2008 874 883
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 874-883
    • Keller, M.1
  • 17
    • 84876109190 scopus 로고    scopus 로고
    • The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury
    • H. Kilicdag et al. The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury Early Hum. Dev. 89 2013 355 360
    • (2013) Early Hum. Dev. , vol.89 , pp. 355-360
    • Kilicdag, H.1
  • 18
    • 34848863953 scopus 로고    scopus 로고
    • Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain
    • J.S. Kim et al. Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain Epilepsia 48 Suppl. 5 2007 S19 S26
    • (2007) Epilepsia , vol.48 , Issue.SUPPL. 5
    • Kim, J.S.1
  • 19
    • 37749013229 scopus 로고    scopus 로고
    • Levetiracetam has no acute effects on brain gamma-aminobutyric acid levels
    • R. Kuzniecky et al. Levetiracetam has no acute effects on brain gamma-aminobutyric acid levels Epilepsy Behav. 12 2008 242 244
    • (2008) Epilepsy Behav. , vol.12 , pp. 242-244
    • Kuzniecky, R.1
  • 20
    • 71249152084 scopus 로고    scopus 로고
    • Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus
    • C.Y. Lee et al. Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus Br. J. Pharmacol. 158 2009 1753 1762
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 1753-1762
    • Lee, C.Y.1
  • 21
    • 84873733279 scopus 로고    scopus 로고
    • Hypothermia and xenon: Novel noble guardians in hypoxic-ischemic encephalopathy?
    • N. Lobo et al. Hypothermia and xenon: novel noble guardians in hypoxic-ischemic encephalopathy? J. Neurosci. Res. 91 2013 473 478
    • (2013) J. Neurosci. Res. , vol.91 , pp. 473-478
    • Lobo, N.1
  • 22
    • 0030574062 scopus 로고    scopus 로고
    • The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata
    • W. Loscher et al. The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata Brain Res. 735 1996 208 216
    • (1996) Brain Res. , vol.735 , pp. 208-216
    • Loscher, W.1
  • 23
    • 0021883921 scopus 로고
    • The incidence and severity of post-asphyxial encephalopathy in full-term infants
    • M.L. Levene, J. Kornberg, and T.H. Williams The incidence and severity of post-asphyxial encephalopathy in full-term infants Early Hum Dev. 11 1985 21 26
    • (1985) Early Hum Dev. , vol.11 , pp. 21-26
    • Levene, M.L.1    Kornberg, J.2    Williams, T.H.3
  • 24
    • 18144398574 scopus 로고    scopus 로고
    • Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain
    • D. Manthey et al. Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain Exp. Neurol. 193 2005 497 503
    • (2005) Exp. Neurol. , vol.193 , pp. 497-503
    • Manthey, D.1
  • 25
    • 2342650104 scopus 로고    scopus 로고
    • Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons
    • G.J. Obermair et al. Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons Eur. J. Neurosci. 19 2004 2109 2122
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 2109-2122
    • Obermair, G.J.1
  • 26
    • 0036120515 scopus 로고    scopus 로고
    • Levetiracetam opposes the action of GABAA antagonists in hypothalamic neurones
    • P. Poulain, and D.G. Margineanu Levetiracetam opposes the action of GABAA antagonists in hypothalamic neurones Neuropharmacology 42 2002 346 352
    • (2002) Neuropharmacology , vol.42 , pp. 346-352
    • Poulain, P.1    Margineanu, D.G.2
  • 27
    • 0037413611 scopus 로고    scopus 로고
    • Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation
    • J.C. Rekling Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation Neurosci. Lett. 335 2003 167 170
    • (2003) Neurosci. Lett. , vol.335 , pp. 167-170
    • Rekling, J.C.1
  • 28
    • 0035987775 scopus 로고    scopus 로고
    • The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents
    • J.M. Rigo et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents Br. J. Pharmacol. 136 2002 659 672
    • (2002) Br. J. Pharmacol. , vol.136 , pp. 659-672
    • Rigo, J.M.1
  • 29
    • 79958045173 scopus 로고    scopus 로고
    • Systemic G-CSF treatment does not improve long-term outcomes after neonatal hypoxic-ischaemic brain injury
    • G.W. Schlager et al. Systemic G-CSF treatment does not improve long-term outcomes after neonatal hypoxic-ischaemic brain injury Exp. Neurol. 230 2011 67 74
    • (2011) Exp. Neurol. , vol.230 , pp. 67-74
    • Schlager, G.W.1
  • 30
    • 79958180028 scopus 로고    scopus 로고
    • Levetiracetam protects hippocampal neurons in culture against hypoxia-induced injury
    • K. Sendrowski et al. Levetiracetam protects hippocampal neurons in culture against hypoxia-induced injury Folia Histochem. Cytobiol. 49 2011 148 152
    • (2011) Folia Histochem. Cytobiol. , vol.49 , pp. 148-152
    • Sendrowski, K.1
  • 31
    • 84869784639 scopus 로고    scopus 로고
    • Hypoxic-ischemic encephalopathy and novel strategies for neuroprotection
    • S. Shankaran Hypoxic-ischemic encephalopathy and novel strategies for neuroprotection Clin. Perinatol. 39 2012 919 929
    • (2012) Clin. Perinatol. , vol.39 , pp. 919-929
    • Shankaran, S.1
  • 32
    • 47049102489 scopus 로고    scopus 로고
    • Off-label use of antiepileptic drugs for the treatment of neonatal seizures
    • F.S. Silverstein, and D.M. Ferriero Off-label use of antiepileptic drugs for the treatment of neonatal seizures Pediatr. Neurol. 39 2008 77 79
    • (2008) Pediatr. Neurol. , vol.39 , pp. 77-79
    • Silverstein, F.S.1    Ferriero, D.M.2
  • 33
    • 79961128386 scopus 로고    scopus 로고
    • Tissue inhibitor of matrix metalloproteinase-1 mediates erythropoietin-induced neuroprotection in hypoxia ischemia
    • R. Souvenir et al. Tissue inhibitor of matrix metalloproteinase-1 mediates erythropoietin-induced neuroprotection in hypoxia ischemia Neurobiol. Dis. 44 2011 28 37
    • (2011) Neurobiol. Dis. , vol.44 , pp. 28-37
    • Souvenir, R.1
  • 34
    • 84880603582 scopus 로고    scopus 로고
    • Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: Electrographic seizures and magnetic resonance imaging evidence of injury
    • P. Srinivasakumar et al. Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury J. Pediatr. 163 2013 465 470
    • (2013) J. Pediatr. , vol.163 , pp. 465-470
    • Srinivasakumar, P.1
  • 35
    • 55849088705 scopus 로고    scopus 로고
    • Sedative and anticonvulsant drugs suppress postnatal neurogenesis
    • V.G. Stefovska et al. Sedative and anticonvulsant drugs suppress postnatal neurogenesis Ann. Neurol. 64 2008 434 445
    • (2008) Ann. Neurol. , vol.64 , pp. 434-445
    • Stefovska, V.G.1
  • 36
    • 40049108004 scopus 로고    scopus 로고
    • HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam
    • R. Trollmann et al. HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam Brain Res. 1199 2008 27 36
    • (2008) Brain Res. , vol.1199 , pp. 27-36
    • Trollmann, R.1
  • 37
    • 34248228678 scopus 로고    scopus 로고
    • Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection
    • Y. Ueda et al. Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection Brain Res. 1151 2007 55 61
    • (2007) Brain Res. , vol.1151 , pp. 55-61
    • Ueda, Y.1
  • 38
    • 84873376680 scopus 로고    scopus 로고
    • Clinical management of seizures in newborns: Diagnosis and treatment
    • L.G. van Rooij et al. Clinical management of seizures in newborns: diagnosis and treatment Paediatr. Drugs 15 2013 9 18
    • (2013) Paediatr. Drugs , vol.15 , pp. 9-18
    • Van Rooij, L.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.