Healthcare-associated infections in pediatric cancer patients: Results of a prospective surveillance study from university hospitals in Germany and Switzerland

BMC Infectious Diseases

Volumn 8, Issue , 2008, Pages

  Simon, Arne ^a   Ammann, Roland A ^b   Bode, Udo ^a   Fleischhack, Gudrun ^a   Wenchel, Hans Martin ^c   Schwamborn, Dorothee ^c   Gravou, Chara ^d   Schlegel, Paul Gerhardt ^e   Rutkowski, Stefan ^e   Dannenberg, Claudia ^f   Körholz, Dieter ^f   Laws, Hans Jürgen ^g   Kramer, Michael H ^h  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^f UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^g UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^h UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; CEFTAZIDIME; CEFTRIAXONE; PIPERACILLIN PLUS TAZOBACTAM;

ADULT; AGED; APPLICATION SITE INFECTION; ARTICLE; ASPERGILLOSIS; BACTEREMIA; BRAIN VENTRICULITIS; CANCER PATIENT; CATHETER INFECTION; CENTRAL VENOUS CATHETERIZATION; CHILDHOOD CANCER; DISEASE ASSOCIATION; DISEASE SURVEILLANCE; GERMANY; HOSPITAL INFECTION; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MICROBIAL CONTAMINATION; MORTALITY; MULTIDRUG RESISTANCE; NEUTROPENIA; ONSET AGE; PNEUMONIA; PROSPECTIVE STUDY; PYREXIA IDIOPATHICA; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RISK FACTOR; SEPSIS; SURGICAL INFECTION; SWITZERLAND; UNIVERSITY HOSPITAL; URINARY TRACT INFECTION; VIRAL GASTROENTERITIS; VIRUS INFECTION; VIRUS ISOLATION; ADOLESCENT; CHILD; CLINICAL TRIAL; CROSS INFECTION; HEALTH SURVEY; HOSPITALIZATION; INCIDENCE; INFANT; INFECTION; METHODOLOGY; MICROBIOLOGY; MULTICENTER STUDY; NEOPLASM; PRESCHOOL CHILD; STATISTICS;

ADOLESCENT; BACTEREMIA; CATHETERIZATION, CENTRAL VENOUS; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; FEVER OF UNKNOWN ORIGIN; GERMANY; HOSPITALS, UNIVERSITY; HUMANS; INCIDENCE; INFANT; INFECTION; NEOPLASMS; NEUTROPENIA; POPULATION SURVEILLANCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SWITZERLAND;

EID: 44649181568     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-8-70     Document Type: Article

References (41)

1. Haupt R Romanengo M Fears T Viscoli C Castagnola E Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: A 12-year experience at a single Italian institution Eur J Cancer 2001, 37(18):2413-2419 10.1016/S0959-8049(01)00274-X 11720836
2. Castagnola E Cesaro S Giacchino M Livadiotti S Tucci F Zanazzo G Caselli D Caviglia I Parodi S Rondelli R Cornelli PE Mura R Santoro N Russo G De Santis R Buffardi S Viscoli C Haupt R Rossi MR Fungal infections in children with cancer: A prospective, multicenter surveillance study Pediatr Infect Dis J 2006, 25(7):634-639 10.1097/ 01.inf.0000220256.69385.2e 16804435
3. Castagnola E Conte M Parodi S Papio F Caviglia I Haupt R Incidence of bacteremias and invasive mycoses in children with high risk neuroblastoma Pediatr Blood Cancer 2007, 49(5):672-677 10.1002/pbc.21070 17039488
4. Castagnola E Molinari AC Giacchino M Chiapello N Moroni C Caviglia I Fratino G Haupt R Incidence of catheter-related infections within 30 days from insertion of Hickman-Broviac catheters Pediatr Blood Cancer 2005
5. Gaur AH Flynn PM Shenep JL Optimum management of pediatric patients with fever and neutropenia Indian J Pediatr 2004, 71(9):825-835 10.1007/ BF02730723 15448391
6. Neville K Renbarger J Dreyer Z Pneumonia in the immunocompromised pediatric cancer patient Semin Respir Infect 2002, 17(1):21-32 10.1053/ srin.2002.31691 11891516
7. Benjamin DK Jr. Miller WC Bayliff S Martel L Alexander KA Martin PL Infections diagnosed in the first year after pediatric stem cell transplantation Pediatr Infect Dis J 2002, 21(3):227-234 10.1097/ 00006454-200203000-00013 12005087
8. Simon A Bode U Beutel K Diagnosis and treatment of catheter-related infections in paediatric oncology: An update Clin Microbiol Infect 2006, 12(7):606-620 10.1111/j.1469-0691.2006.01416.x 16774556
9. Simon A Fleischhack G Hasan C Bode U Engelhart S Kramer MH Surveillance for nosocomial and central line-related infections among pediatric hematology-oncology patients Infect Control Hosp Epidemiol 2000, 21(9):592-596 10.1086/501809 11001263
10. Urrea M Rives S Cruz O Navarro A Garcia JJ Estella J Nosocomial infections among pediatric hematology/oncology patients: Results of a prospective incidence study Am J Infect Control 2004, 32(4):205-208 10.1016/j.ajic.2003.10.013 15175614
11. Paulus SC van Saene HK Hemsworth S Hughes J Ng A Pizer BL A prospective study of septicaemia on a paediatric oncology unit: A three-year experience at The Royal Liverpool Children's Hospital, Alder Hey, UK Eur J Cancer 2005, 41(14):2132-2140 10.1016/j.ejca.2005.04.037 16129600
12. Laws HJ Kobbe G Dilloo D Dettenkofer M Meisel R Geisel R Haas R Gobel U Schulze-Robbecke R Surveillance of nosocomial infections in paediatric recipients of bone marrow or peripheral blood stem cell transplantation during neutropenia, compared with adult recipients J Hosp Infect 2005 16242206
13. Raymond J Aujard Y Nosocomial infections in pediatric patients: A European, multicenter prospective study. European Study Group Infect Control Hosp Epidemiol 2000, 21(4):260-263 10.1086/501755 10782588
14. Carlisle PS Gucalp R Wiernik PH Nosocomial infections in neutropenic cancer patients Infect Control Hosp Epidemiol 1993, 14(6):320-324 8360462
15. Dettenkofer M Ebner W Bertz H Babikir R Finke J Frank U Ruden H Daschner FD Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation Bone Marrow Transplant 2003, 31(9):795-801 10.1038/ sj.bmt.1703920 12732887
16. Simon A Fleischhack G Wiszniewsky G Hasan C Bode U Kramer MH Influence of Prolonged Use of Intravenous Administration Sets in Paediatric Cancer Patients on CVAD-related Bloodstream Infection Rates and Hospital Resources Infection 2006, 34(5):258-263 10.1007/s15010-006-5646-y 17033749
17. Simon A Groger N Wilkesmann A Hasan C Wiszniewsky G Engelhart S Kramer MH Bode U Ammann RA Fleischhack G Restricted use of glycopeptides in paediatric cancer patients with fever and neutropenia Int J Antimicrob Agents 2006, 28(5):417-422 10.1016/j.ijantimicag.2006.08.007 17046210
18. Simon A Besuden M Vezmar S Hasan C Lampe D Kreutzberg S Glasmacher A Bode U Fleischhack G Itraconazole prophylaxis in pediatric cancer patients receiving conventional chemotherapy or autologous stem cell transplants Support Care Cancer 2006 Aug 30 (Epub ahead of Print)
19. National Nosocomial Infections Surveillance (NNIS) System National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004, 32(8):470-485 10.1016/j.ajic.2004.10.001 15573054
20. Simon A Oncoped Study website http://www.onkopaednki.de/
21. Goldstein B Giroir B Randolph A International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics Pediatr Crit Care Med 2005, 6(1):2-8 10.1097/01.PCC.0000149131.72248.E6 15636651
22. Ascioglu S Rex JH de Pauw B Bennett JE Bille J Crokaert F Denning DW Donnelly JP Edwards JE Erjavec Z Fiere D Lortholary O Maertens J Meis JF Patterson TF Ritter J Selleslag D Shah PM Stevens DA Walsh TJ Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: An international consensus Clin Infect Dis 2002, 34(1):7-14 10.1086/323335 11731939
23. O'Grady NP Alexander M Dellinger EP Gerberding JL Heard SO Maki DG Masur H McCormick RD Mermel LA Pearson ML Raad Randolph A Weinstein RA Guidelines for the prevention of intravascular catheter-related infections Infect Control Hosp Epidemiol 2002, 23(12):759-769 10.1086/ 502007 12517020
24. Aledo A Heller G Ren L Gardner S Dunkel I McKay SW Flombaum C Brown AE Septicemia and septic shock in pediatric patients: 140 consecutive cases on a pediatric hematology-oncology service J Pediatr Hematol Oncol 1998, 20(3):215-221 10.1097/00043426-199805000-00006 9628432
25. Upton A Kirby KA Carpenter P Boeckh M Marr KA Invasive aspergillosis following hematopoietic cell transplantation: Outcomes and prognostic factors associated with mortality Clin Infect Dis 2007, 44(4):531-540 10.1086/510592 17243056
26. Haut C Oncological emergencies in the pediatric intensive care unit AACN Clin Issues 2005, 16(2):232-245 15876890
27. Wisplinghoff H Seifert H Tallent SM Bischoff T Wenzel RP Edmond MB Nosocomial bloodstream infections in pediatric patients in United States hospitals: Epidemiology, clinical features and susceptibilities Pediatr Infect Dis J 2003, 22(8):686-691 12913767
28. Paterson DL Bonomo RA Extended-spectrum beta-lactamases: A clinical update Clin Microbiol Rev 2005, 18(4):657-686 1265908 16223952 10.1128/ CMR.18.4.657-686.2005
29. Simon A Schildgen O Maria Eis-Hubinger A Hasan C Bode U Buderus S Engelhart S Fleischhack G Norovirus outbreak in a pediatric oncology unit Scand J Gastroenterol 2006, 41(6):693-699 10.1080/00365520500421694 16716968
30. Rayani A Bode U Habas E Fleischhack G Engelhart S Exner M Schildgen O Bierbaum G Maria Eis-Hubinger A Simon A Rotavirus infections in paediatric oncology patients: A matched-pairs analysis Scand J Gastroenterol 2007, 42(1):81-87 10.1080/00365520600842179 17190767
31. van de Wetering MD Kuijpers TW Taminiau JA ten Kate FJ Caron HN Pseudomembranous and neutropenic enterocolitis in pediatric oncology patients Support Care Cancer 2003, 11(9):581-586 10.1007/ s00520-003-0483-3 12768402
32. Donskey CJ Antibiotic regimens and intestinal colonization with antibiotic-resistant gram-negative bacilli Clin Infect Dis 2006, 43(Suppl 2):S62-9 10.1086/504481 16894517
33. Brook I Pseudomembranous colitis in children J Gastroenterol Hepatol 2005, 20(2):182-186 10.1111/j.1440-1746.2004.03466.x 15683418
34. McDonald LC Killgore GE Thompson A Owens RC Jr. Kazakova SV Sambol SP Johnson S Gerding DN An epidemic, toxin gene-variant strain of Clostridium difficile N Engl J Med 2005, 353(23):2433-2441 10.1056/ NEJMoa051590 16322603
35. Bartlett JG Perl TM The new Clostridium difficile - what does it mean? N Engl J Med 2005, 353(23):2503-2505 10.1056/NEJMe058221 16322604
36. Gaur AH Liu T Knapp KM Daw NC Rao BN Neel MD Rodriguez-Galindo C Brand D Adderson EE Infections in children and young adults with bone malignancies undergoing limb-sparing surgery Cancer 2005, 104(3):602-610 10.1002/cncr.21212 15952202
37. Neville HL Lally KP Pediatric Surgical Wound Infection. Seminars in Pediatric Infectious Diseases 2001, 12(2):124-129 10.1053/spid.2001.22786
38. Trampuz A Zimmerli W Antimicrobial agents in orthopaedic surgery: Prophylaxis and treatment Drugs 2006, 66(8):1089-1105 10.2165/ 00003495-200666080-00005 16789794
39. McCann S Byrne JL Rovira M Shaw P Ribaud P Sica S Volin L Olavarria E Mackinnon S Trabasso P VanLint MT Ljungman P Ward K Browne P Gratwohl A Widmer AF Cordonnier C Outbreaks of infectious diseases in stem cell transplant units: A silent cause of death for patients and transplant programmes Bone Marrow Transplant 2004, 33(5):519-529 10.1038/ sj.bmt.1704380 14743201
40. Hicks KL Chemaly RF Kontoyiannis DP Common community respiratory viruses in patients with cancer: More than just "common colds" Cancer 2003, 97(10):2576-2587 10.1002/cncr.11353 12733157
41. Coffin SE Zaoutis TE Infection control, hospital epidemiology, and patient safety Infect Dis Clin North Am 2005, 19(3):647-665 10.1016/ j.idc.2005.05.002 16102654