Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cgmp-protein kinase g modulation

Circulation Research

Volumn 114, Issue 5, 2014, Pages 823-832

  Seo, Kinya ^a   Rainer, Peter P ^a,b   Lee, Dong Ik ^a   Hao, Scarlett ^a   Bedja, Djahida ^a   Birnbaumer, Lutz ^c   Cingolani, Oscar H ^a   Kass, David A ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cardiac; cardiac; Duchenne; muscle contraction; muscular dystrophy; myocytes; pharmacology; stress mechanics

Indexed keywords

CALCIUM; CYCLIC GMP DEPENDENT PROTEIN KINASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 5A; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; UTROPHIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CELL LEVEL; CELL ISOLATION; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; ENZYME INHIBITION; FEMALE; GENE DELETION; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; MALE; MECHANICAL STRESS; MECHANOTRANSDUCTION; MODULATION; MOUSE MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STRESS STIMULATED CONTRACTILITY;

CARDIAC; MUSCLE CONTRACTION; MUSCULAR DYSTROPHY, DUCHENNE; MYOCYTES, CARDIAC; PHARMACOLOGY; STRESS MECHANICS;

ANIMALS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DYSTROPHIN; FEMALE; HEART; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCULAR DYSTROPHY, DUCHENNE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PAPILLARY MUSCLES; PHOSPHODIESTERASE 5 INHIBITORS; STRESS, MECHANICAL; SYSTOLE; TRPC CATION CHANNELS;

EID: 84895917776     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.114.302614     Document Type: Article

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