Percutaneous delivery of econazole using microemulsion as vehicle: Formulation, evaluation and vesicle-skin interaction

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 120-131

  Ge, Shumin ^a   Lin, Yuanyuan ^a   Lu, Haoyang ^a   Li, Qi ^a   He, Jian ^b   Chen, Bao ^a   Wu, Chuanbin ^a   Xu, Yuehong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b China Resources Sanjiu Medical and Pharmaceutical Co Ltd   (China)

Author keywords

ATR FTIR; CLSM; Econazole nitrate; Microemulsion; Percutaneous delivery; TEM; Vesicle skin interaction

Indexed keywords

COSURFACTANT; DIETHYLENE GLYCOL MONOETHYL ETHER; DRUG CARRIER; ECONAZOLE; SOLUTOL HS 15; SORBITAN OLEATE; WATER; ACYLGLYCEROL; ANTIFUNGAL AGENT; EMULSION; ETHYLENE GLYCOL DERIVATIVE; HEXOSE; LABRAFIL M 1944 CS; MACROGOL DERIVATIVE; STEARIC ACID DERIVATIVE; SURFACTANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RETENTION; DRUG SOLUBILITY; DRUG STABILITY; ELECTRIC CONDUCTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; RESPONSE SURFACE METHOD; SHEAR RATE; SHEAR STRESS; SKIN PERMEABILITY; SKIN SURFACE; TRANSMISSION ELECTRON MICROSCOPY; VISCOMETRY; WATER CONTENT; ANIMAL; CHEMISTRY; CONFOCAL MICROSCOPY; EMULSION; FEASIBILITY STUDY; FEMALE; INFRARED SPECTROSCOPY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; PERMEABILITY; PHARMACEUTICS; PROCEDURES; SKIN; SKIN ABSORPTION; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIFUNGAL AGENTS; DRUG CARRIERS; ECONAZOLE; EMULSIONS; ETHYLENE GLYCOLS; FEASIBILITY STUDIES; FEMALE; GLYCERIDES; HEXOSES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; PERMEABILITY; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STEARIC ACIDS; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 84895869590     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.012     Document Type: Article

References (37)

1. Y.G. Bachhav, K. Mondon, Y.N. Kalia, R. Gurny, and M. Moller Novel micelle formulation to increase cutaneous bioavailability of azole antifungals Journal of Controlled Release 153 2011 126 132
2. M. Boncheva, F. Damien, and V. Normand Molecular organization of the lipid matrix in intact stratum corneum using ATR-FTIR spectroscopy Biochimica et Biophysica Acta 2008 1344 1355
3. J.L.V. Dos Anjos, and A. Alonso Terpenes increase the portioning and molecular dynamics of an amphipathic spin label in stratum corneum membranes International Journal of Pharmaceutics 350 2008 103 112
4. F. Dreher, P. Walde, P. Walther, and E. Wehrli Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport Journal of Controlled Release 45 1997 131 140
5. A.M. Dyas, and H. Delargy Econazole nitrate K. Florey, Analytical Profiles of Drug Substances and Excipients 23 1994 Academic Press New York 125 151
6. M. Fanun, V. Papadimitriou, and A. Xenakis Characterization of cephalexin loaded nonionic microemulsions Journal of Colloid and Interface Science 361 2011 115 121
7. T.P. Formariz, V.H.V. Sarmento, A.A. Silva-Junior, and M.V. Scarpa Doxorubicin biocompatible O/W microemulsion stabilized by mixed surfactant containing soya phosphatidylcholine Colloids Surfaces B: Biointerfaces 51 2006 54 61
8. S.A. Fouad, E.B. Basalious, M.A. EI-Nabarawi, and S. Tayei Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation International Journal of Pharmaceutics 453 2013 569 578
9. J.F. Hao, F.G. Wang, X.D. Wang, D.R. Zhang, Y.P. Bi, Y.S. Gao, X.M. Zhao, and Q. Zhang Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design European Journal of Pharmaceutical Sciences 47 2012 497 505
10. A. Hasanovic, R. Winkler, G.P. Resch, and C. Valenta Modification of the conformational skin structure by treatment with liposomal formulations and its correlation to the penetration depth of acyclovir European Journal of Pharmaceutics and Biopharmaceutics 19 2011 76 81
11. E.E. Hassan, R.C. Parish, and J.M. Gallo Optimized formulation of magnetic chitosan microspheres containing the anticancer agent, oxantrazole Pharmaceutical Research 9 1992 390 397
12. R.M. Hathout, S. Mansour, A.S. Geneidi, and N.D. Mortada Visualization, dermatopharmacokinetic anslysis and monitoring the conformational effects of a microemulsion formulation in the skin stratum corneum Journal of Colloid and Interface Science 354 2011 124 130
13. R.C. Heel, R.N. Brogden, T.M. Speight, and G.S. Avery Econazole: a review of its antifungal activity and therapeutic efficacy Drugs 16 1978 177 201
14. S. Heuschkel, A. Goebel, and R.H.H. Neubert Microemulsions-morden colloidal carrier for dermal and transdermal drug delivery Journal of Pharmaceutical Sciences 97 2008 603 631
15. S. Heuschkel, J. Wohlrab, and R.H.H. Neubert Dermal and transdermal targeting of dihydroavenanthramide D using enhancer molecules and novel microemulsions European Journal of Pharmaceutics and Biopharmaceutics 72 2009 552 560
16. Won M. Kim B.S, Lee K.M. Yang, and Kim C. S In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug Drug Delivery 15 2008 465 469
17. J.V. Kloet, L.L. Schramm, and B. Shelfantook Application of the hydrophile-lipophile balance concept to the classification of demulsifiers and bituminous forth and its components Fuel Processing Technology 75 2002 9 26
18. Y. Liu, P. Zhang, N.P. Feng, and X. Zhang Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin International Journal of Pharmaceutics 365 2009 136 142
19. G.M.E. Maghraby Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants International Journal of Pharmaceutics 355 2008 285 292
20. C. Malcolmson, and M.J. Lawrence A comparison of the incorporation of model steroids into non-ionic micellar and microsmulsion systems Journal of Pharmacology & Pharmacotherapeutics 45 1993 141 143
21. C. Malcolmson, C. Satra, S. Kantaria, A. Sidhu, and M.J. Lawrence Effect of oil on the level of solubilization of testosterone propionate into nonionic oil-in-water microsmulsions Journal of Pharmaceutical Sciences 87 1998 109 116
22. M. Manconi, C. Caddeo, C. Sinico, D. Valenti, M.C. Mostallino, G. Biggio, and A.M. Fadda Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle-skin interaction European Journal of Pharmaceutics and Biopharmaceutics 78 2011 27 35
23. R.H. Muller, and M.S.A. Radtke Wissing Nanostructured lipid matrices for improved microencapsulation of drugs International Journal of Pharmaceutics 242 2002 121 128
24. R. Naeff Feasibility of topical liposome drugs produced on an industrial scale Advanced Drug Delivery Reviews 18 1996 343 347
25. Y. Obata, S. Utsumi, H. Watanabe, M. Suda, Y. Tokudome, M. Otsuka, and K. Takayama Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers International Journal of Pharmaceutics 389 2010 18 23
26. M.P.Y. Piemi, D. Korner, S. Benita, and J.P. Marty Positively and negatively charged submicron emulsion for enhanced topical delivery of antifungal drugs Journal of Controlled Release 58 1999 177 187
27. G. Rodriguez, L. Barbosa-Barros, L. Rubio, M. Cocera, A. Diez, J. Estelrich, R. Pons, J. Caelles, A.D.L. Maza, and O. Lopez Conformational changes in stratum corneum lipids by effect of bicellar systems Langmuir 25 2009 10595 10603
28. V. Sanna, G. Caria, and A. Mariani Effect of lipid nanoparticles containing fatty alcohols having different chain length on the ex vivo skin permeability of Econazole nitrate Powder Technology 201 2011 32 36
29. C. Sinico, M. Manconi, M. Peppi, and F. Lai Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle-skin interaction Journal of Controlled Release 103 2005 123 136
30. E.B. Souto, S.A. Wissing, C.M. Barbosa, and R.H. Muller Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery International Journal of Pharmaceutics 278 2004 71 77
31. B.A.I. Van den Bergh, J. Vroom, H. Gerritsen, H.E. Junginger, and J.A. Bouwstra Interaction of elastic and rigid vesicles with human skin in vitro: electron microscopy and two-photon excitation microscopy Biochimica et Biophysica Acta 1461 1999 155 173
32. P. Verma, and K. Pathak Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation Nanomedicine: Nanotechnology, Biology and Medicine 8 2012 489 496
33. Y. Yokomizo Effect of phosphatidylcholine on the percutaneous penetration of drugs through the dorsal skin of guinea pigs in vitro; and analysis of the molecular mechanism, using attenuated total reflectance fourier transform infrared (ATR-FTIR) spectroscopy Journal of Controlled Release 42 1996 249 262
34. Y. Yuan, S.M. Li, F. Mo, and D.F. Zhong Investigation of microemulsion system for transdermal delivery of meloxicam International Journal of Pharmaceutics 321 2006 117 123
35. J. Zhang, and B. Michniak-kohn Investigation of microemulsion microstructure and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine International Journal of Pharmaceutics 421 2011 34 44
36. X.Y. Zhang, J.P. Liu, H. Qiao, H. Liu, J.M. Ni, W.L. Zhang, and Y.B. Shi Formulation optimization of dihydroartemisinin nanostructured lipid carrier using response surface methodology Powder Technology 197 2010 120 128
37. K. Zielińska, K.A. Wilk, A. Jezierski, and T. Jesionowski Microstructure and structural transition in microemulsions stabilized by aldonamide-type surfactants Journal of Colloid and Interface Science 321 2008 408 417