A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Metabolic Brain Disease

Volumn 29, Issue 1, 2014, Pages 37-45

  Benedek, Gil ^a,b   Zhu, Wenbin ^b   Libal, Nicole ^b   Casper, Amanda ^b   Yu, Xiaolin ^a,b   Meza Romero, Roberto ^a,b   Vandenbark, Arthur A ^a,b   Alkayed, Nabil J ^b   Offner, Halina ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Immunotherapy; Inflammation; MHC class II invariant chain; Recombinant T cell receptor Ligand; Stroke

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; CD74 ANTIGEN; CYTOKINE; HLA DR ALPHA1 ANTIGEN MOG 35 55; HLA DR1 ANTIGEN; MACROPHAGE MIGRATION INHIBITION FACTOR; PEPTIDE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; B LYMPHOCYTE ANTIGEN; HLA ANTIGEN CLASS 2; HLA B15 ANTIGEN; HLA DRB1 ANTIGEN; HLA-B*15:02 ANTIGEN; HYBRID PROTEIN; INVARIANT CHAIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); NERVE PROTEIN; PEPTIDE FRAGMENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ATROPHY; BRAIN CORTEX; BRAIN INFARCTION SIZE; CELL ACTIVATION; CELL SURFACE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; EXPERIMENTAL STROKE; HEMISPHERE; IMMUNOCOMPETENT CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOCYTE; MOUSE; NERVE CELL INHIBITION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PROTEIN BINDING; PROTEIN DOMAIN; REPERFUSION INJURY; ANIMAL; BIOSYNTHESIS; DRUG ADMINISTRATION; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION PROFILING; GENETICS; HUMAN; IMMUNOLOGY; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; MICROGLIA; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; RANDOMIZATION; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; ATROPHY; CHEMOTAXIS, LEUKOCYTE; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-B15 ANTIGEN; HLA-DRB1 CHAINS; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, TRANSGENIC; MICROGLIA; MONOCYTES; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RANDOM ALLOCATION; RECOMBINANT FUSION PROTEINS; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84895866825     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-013-9440-0     Document Type: Article

References (29)

1. Akiyoshi K, Dziennis S, Palmateer J, Ren X, Vandenbark AA, Offner H, Herson PS, Hurn PD (2011) Recombinant T cell receptor ligands improve outcome after experimental cerebral ischemia. Transl Stroke Res 2(3):404-410. doi:10.1007/s12975-011-0085-1
2. Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows GG, Bourdette D, Offner H, Bucala R, Vandenbark AA (2013) Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects. Eur J Immunol 43(5):1309 - 1321. doi:10.1002/eji.201243162
3. Burrows GG, Bebo BF Jr, Adlard KL, Vandenbark AA, Offner H (1998) Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis. J Immunol 161(11):5987-5996 (Pubitemid 28535967)
4. Burrows GG, Chang JW, Bachinger HP, Bourdette DN, Offner H, Vandenbark AA (1999) Design, engineering and production of functional single-chain T cell receptor ligands. Protein Eng 12(9):771-778 (Pubitemid 29472084)
5. Burrows GG, Chou YK, Wang C, Chang JW, Finn TP, Culbertson NE, Kim J, Bourdette DN, Lewinsohn DA, Lewinsohn DM, Ikeda M, Yoshioka T, Allen CN, Offner H, Vandenbark AA (2001) Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells. J Immunol 167(8):4386-4395 (Pubitemid 32954315)
6. Emsley HC, Smith CJ, Georgiou RF, Vail A, Tyrrell PJ, Barberan EM, Rothwell NJ, Hopkins SJ (2005) Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients. Stroke 36(2):228-229. doi:10.1161/01.STR.0000155197.88944.ac, author reply 228-229
7. Fan H, Hall P, Santos LL, Gregory JL, Fingerle-Rowson G, Bucala R, Morand EF, Hickey MJ (2011) Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase. J Immunol 186(8):4915-4924. doi:10.4049/jimmunol.1003713
8. Gee JM, Kalil A, Shea C, Becker KJ (2007) Lymphocytes: potential mediators of postischemic injury and neuroprotection. Stroke 38(2 Suppl):783-788. doi:10.1161/01.STR.0000248425.59176.7b (Pubitemid 46188255)
9. Gonzalez-Gay MA, Zanelli E, Khare SD, Krco CJ, Zhou P, Inoko H, Griffiths MM, Luthra HS, David CS (1996) Human leukocyte antigen-DRB1*1502 (DR2Dw12) transgene reduces incidence and severity of arthritis in mice. Hum Immunol 50(1):54-60 (Pubitemid 26282611)
10. Huan J, Subramanian S, Jones R, Rich C, Link J, Mooney J, Bourdette DN, Vandenbark AA, Burrows GG, Offner H (2004) Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch. J Immunol 172(7):4556-4566 (Pubitemid 38375273)
11. Hurn PD, Subramanian S, Parker SM, Afentoulis ME, Kaler LJ, Vandenbark AA, Offner H (2007) T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J Cereb Blood Flow Metab 27(11):1798-1805. doi:10.1038/sj.jcbfm.9600482 (Pubitemid 47624547)
12. Inacio AR, Bucala R, Deierborg T (2011a) Lack of macrophage migration inhibitory factor in mice does not affect hallmarks of the inflammatory/immune response during the first week after stroke. J Neuroinflammation 8:75. doi:10.1186/1742-2094-8-75
13. Inacio AR, Ruscher K, Leng L, Bucala R, Deierborg T (2011b) Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke. J Cereb Blood Flow Metab 31(4):1093-1106. doi:10.1038/jcbfm.2010.194
14. Inacio AR, Ruscher K, Wieloch T (2011c) Enriched environment downregulates macrophage migration inhibitory factor and increases parvalbumin in the brain following experimental stroke. Neurobiol Dis 41(2):270-278. doi:10.1016/j.nbd.2010.09.015
15. Nilupul Perera M, Ma HK, Arakawa S, Howells DW, Markus R, Rowe CC, Donnan GA (2006) Inflammation following stroke. J Clin Neurosci 13(1):1-8. doi:10.1016/j.jocn.2005.07.005 (Pubitemid 43061121)
16. Offner H, Subramanian S, Parker SM, Afentoulis ME, Vandenbark AA, Hurn PD (2006a) Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab 26(5):654-665. doi:10.1038/sj.jcbfm. 9600217
17. Offner H, Subramanian S, Parker SM, Wang C, Afentoulis ME, Lewis A, Vandenbark AA, Hurn PD (2006b) Splenic atrophy in experimental stroke is accompanied by increased regulatory Tcells and circulating macrophages. J Immunol 176(11):6523-6531 (Pubitemid 43787834)
18. Seifert HA, Hall AA, Chapman CB, Collier LA, Willing AE, Pennypacker KR (2012) A transient decrease in spleen size following stroke corresponds to splenocyte release into systemic circulation. J Neuroimmune Pharmacol 7(4):1017-1024. doi:10.1007/s11481-012-9406-8
19. Sinha S, Subramanian S, Miller L, Proctor TM, Roberts C, Burrows GG, Vandenbark AA, Offner H (2009) Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand. J Neurosci 29(12):3816-3823. doi:10.1523/JNEUROSCI.5812-08.2009
20. Sinha S, Subramanian S, Proctor TM, Kaler LJ, Grafe M, Dahan R, Huan J, Vandenbark AA, Burrows GG, Offner H (2007) A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS. J Neurosci 27(46):12531-12539. doi:10.1523/JNEUROSCI.3599-07.2007 (Pubitemid 350127826)
21. Smith CJ, Emsley HC, Gavin CM, Georgiou RF, Vail A, Barberan EM, del Zoppo GJ, Hallenbeck JM, Rothwell NJ, Hopkins SJ, Tyrrell PJ (2004) Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol 4:2. doi:10.1186/1471-2377-4-2
22. Stevens SL, Bao J, Hollis J, Lessov NS, Clark WM, Stenzel-Poore MP (2002) The use of flow cytometry to evaluate temporal changes in inflammatory cells following focal cerebral ischemia in mice. Brain Res 932(1-2):110-119 (Pubitemid 34241600)
23. Subramanian S, Zhang B, Kosaka Y, Burrows GG, Grafe MR, Vandenbark AA, Hurn PD, Offner H (2009) Recombinant T cell receptor ligand treats experimental stroke. Stroke 40(7):2539-2545. doi:10.1161/STROKEAHA.108.543991
24. Turtzo LC, Li J, Persky R, Benashski S, Weston G, Bucala R, Venna VR, McCullough LD (2013) Deletion of macrophage migration inhibitory factor worsens stroke outcome in female mice. Neurobiol Dis 54:421-431. doi:10.1016/j.nbd.2013. 01.016
25. Vandenbark AA, Meza-Romero R, Benedek G, Andrew S, Huan J, Chou YK, Buenafe AC, Dahan R, Reiter Y, Mooney JL, Offner H, Burrows GG (2013) A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance. J Autoimmun 40:96-110. doi:10.1016/j.jaut.2012.08. 004
26. Vandenbark AA, Rich C, Mooney J, Zamora A, Wang C, Huan J, Fugger L, Offner H, Jones R, Burrows GG (2003) Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. J Immunol 171(1):127-133 (Pubitemid 36745280)
27. Wang PY, Kao CH, Mui MY, Wang SJ (1993) Leukocyte infiltration in acute hemispheric ischemic stroke. Stroke 24(2):236-240 (Pubitemid 23043462)
28. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G (2000) Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 342(3):145-153. doi:10.1056/NEJM200001203420301
29. Ziv I, Fleminger G, Djaldetti R, Achiron A, Melamed E, Sokolovsky M (1992) Increased plasma endothelin-1 in acute ischemic stroke. Stroke 23(7):1014-1016