A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation

Carcinogenesis

Volumn 35, Issue 3, 2014, Pages 670-682

  Mahmood, Sardar Faisal ^a,b   Gruel, Nadège ^b,c   Chapeaublanc, Elodie ^a,b   Lescure, Aurianne ^b,c,d   Jones, Thouis ^b,c,d   Reyal, Fabien ^a,b,e   Vincent Salomon, Anne ^a,b,f   Raynal, Virginie ^a,b   Pierron, Gaëlle ^a,b   Perez, Franck ^a,b,d   Camonis, Jacques ^a,b,d   DelNery, Elaine ^b,c,d   Delattre, Olivier ^a,b   Radvanyi, François ^a,b   Bernard Pierrot, Isabelle ^a,b  

^a INSTITUT CURIE   (France)

^b Centre de Recherche InstitutCurie   (France)

^c Translational Research Department   (France)

^d SAINT LOUIS HOSPITAL   (France)

^e Surgery Department InstitutCurie   (France)

^f Anatomopathology Department InstitutCurie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHRAC1 PROTEIN; EIF3H PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; RAD21 PROTEIN; SMALL INTERFERING RNA; TANC2 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMPLICON; ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; BREAST; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL ADHESION; CELL CYCLE ARREST; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CELL VIABILITY; CHROMOSOME 17Q; CHROMOSOME 17Q23; CHROMOSOME 8Q; CHROMOSOME 8Q23; CHROMOSOME 8Q24.3; CLONOGENESIS; CONTROLLED STUDY; DRUG SCREENING; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE; PRIORITY JOURNAL; RNA INTERFERENCE;

BASE SEQUENCE; BREAST NEOPLASMS; CELL DIVISION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 8; DNA PRIMERS; DNA-BINDING PROTEINS; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; NUCLEAR PROTEINS; NUCLEOPROTEINS; PHOSPHOPROTEINS; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 84895813167     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt351     Document Type: Article

References (33)

1. Weinstein,I.B. et al. (2008) Oncogene addiction. Cancer Res., 68, 3077- 3080; discussion 3080.
2. Al-Kuraya,K. et al. (2004) Prognostic relevance of gene amplifications and coamplifications in breast cancer. Cancer Res., 64, 8534-8540.
3. Collins,C. et al. (2001) Comprehensive genome sequence analysis of a breast cancer amplicon. Genome Res., 11, 1034-1042.
4. Hyman,E. et al. (2002) Impact of DNA amplification on gene expression patterns in breast cancer. Cancer Res., 62, 6240-6245.
5. Ethier,S.P. (2003) Identifying and validating causal genetic alterations in human breast cancer. Breast Cancer Res. Treat., 78, 285-287.
6. Faber,A.C. et al. (2010) Differences underlying EGFR and HER2 oncogene addiction. Cell Cycle, 9, 851-852.
7. Kao,J. et al. (2006) RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes. Genes. Chromosomes Cancer, 45, 761-769.
8. Bernard-Pierrot,I. et al. (2008) Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer. Cancer Res., 68, 7165-7175.
9. Yang,Z.Q. et al. (2010) Transforming properties of 8p11-12 amplified genes in human breast cancer. Cancer Res., 70, 8487-8497.
10. Yang,Z.Q. et al. (2006) Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. Cancer Res., 66, 11632-11643.
11. Chirgwin,J.M. et al. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299.
12. Coombs,L.M. et al. (1990) Simultaneous isolation of DNA, RNA, and antigenic protein exhibiting kinase activity from small tumor samples using guanidine isothiocyanate. Anal. Biochem., 188, 338-343.
13. Idbaih,A. et al. (2005) Two types of chromosome 1p losses with opposite significance in gliomas. Ann. Neurol., 58, 483-487.
14. Vincent-Salomon,A. et al. (2007) Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity. Breast Cancer Res., 9, R24.
15. Barretina,J. et al. (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483, 603-607.
16. Reyal,F. et al. (2005) Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes-a study of 130 invasive ductal breast carcinomas. Cancer Res., 65, 1376-1383.
17. Irizarry,R.A. et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics, 4, 249-264.
18. Bolstad,B.M. et al. (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics, 19, 185-193.
19. Dai,M. et al. (2005) Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res., 33, e175.
20. Brideau,C. et al. (2003) Improved statistical methods for hit selection in high-throughput screening. J. Biomol. Screen., 8, 634-647.
21. Malo,N. et al. (2006) Statistical practice in high-throughput screening data analysis. Nat Biotechnol., 24, 167-175.
22. Birmingham,A. et al. (2009) Statistical methods for analysis of highthroughput RNA interference screens. Nat. Methods, 6, 569-575.
23. Györffy,B. et al. (2010) An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat., 123, 725-731.
24. Atienza,J.M. et al. (2005) Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells. Mol. Cancer Ther., 4, 361-368.
25. Zhang,L. et al. (2008) An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3. J. Biol. Chem., 283, 24047-24060.
26. Kukimoto,I. et al. (2004) The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. Mol. Cell, 13, 265-277.
27. Bauerschmidt,C. et al. (2010) Cohesin promotes the repair of ionizing radiation- induced DNA double-strand breaks in replicated chromatin. Nucleic Acids Res., 38, 477-487.
28. Lan,L. et al. (2010) The ACF1 complex is required for DNA double-strand break repair in human cells. Mol. Cell, 40, 976-987.
29. Xu,H. et al. (2010) Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice. PLoS One, 5, e12112.
30. Xu,H. et al. (2011) Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers. Breast Cancer Res., 13, R9.
31. Wu,J. et al. (2012) Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene, 31, 333-341.
32. Wienke,D. et al. (2007) The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Res., 67, 10230-10240.
33. Luo,M. et al. (2010) Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett., 289, 127-139.