Functional polymorphisms of TLR8 are associated with hepatitis C virus infection

Immunology

Volumn 141, Issue 4, 2014, Pages 540-548

  Wang, Chiou Huey ^a,b   Eng, Hock Liew ^c   Lin, Kuei Hsiang ^a   Liu, Hsiang Chun ^b   Chang, Cheng Hsien ^a   Lin, Tsun Mei ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b E DA HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Hepatitis C virus; Polymorphisms; Promoter; Stimulation; Toll like receptor 8

Indexed keywords

FIREFLY LUCIFERASE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; MESSENGER RNA; RESIQUIMOD; TOLL LIKE RECEPTOR 8;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; ENZYME ACTIVITY; EX VIVO STUDY; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOMODULATION; LIVER CELL CARCINOMA; MACROPHAGE; MALE; MONOCYTE; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RNA STABILITY; SIGNAL TRANSDUCTION; TOLL LIKE RECEPTOR 8 GENE;

HEPATITIS C VIRUS; POLYMORPHISMS; PROMOTER; STIMULATION; TOLL-LIKE RECEPTOR 8;

ADULT; BINDING SITES; CASE-CONTROL STUDIES; CYTOKINES; DNA; GENES, REPORTER; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HELA CELLS; HEPATITIS C, CHRONIC; HUMANS; IMMUNITY, INNATE; LEUKOCYTES, MONONUCLEAR; LUCIFERASES; MALE; NF-KAPPA B; ODDS RATIO; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 8; TRANSFECTION;

EID: 84895809388     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12211     Document Type: Article

References (28)

1. Kontorinis N, Agarwal K, Dieterich DT. Current status of the use of growth factors and other adjuvant medications in patients receiving peg interferon and ribavirin. Rev Gastroenterol Disord 2004; 4(Suppl. 1):S39-47.
2. Morgan RL, Baack B, Smith BD, Yartel A, Pitasi M, Falck-Ytter Y. Eradication of hepatitis C virus infection and the development of hepatocellular carcinoma: a meta-analysis of observational studies. Ann Intern Med 2013; 158:329-37.
3. Eid AJ, Brown RA, Paya CV, Razonable RR. Association between toll-like receptor polymorphisms and the outcome of liver transplantation for chronic hepatitis C virus. Transplantation 2007; 84:511-6.
4. Sawhney R, Visvanathan K. Polymorphisms of toll-like receptors and their pathways in viral hepatitis. Antivir Ther 2011; 16:443-58.
5. Cervantes JL, Weinerman B, Basole C, Salazar JC. TLR8: the forgotten relative revindicated. Cell Mol Immunol 2012; 9:434-8.
6. Chuang TH, Ulevitch RJ. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 2000; 11:372-8.
7. Sakaki M, Makino R, Hiroishi K et al. Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression. Hepatol Res 2010; 40:1219-26.
8. Sarvestani ST, Williams BR, Gantier MP. Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing. J Interferon Cytokine Res 2012; 32:350-61.
9. Mockenhaupt FP, Cramer JP, Hamann L et al. Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci USA 2006; 103:177-82.
10. Netea MG, Wijmenga C, O'Neill LA. Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol 2012; 13:535-42.
11. Schroder NW, Schumann RR. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 2005; 5:156-64.
12. Cheng PL, Eng HL, Chou MH, You HL, Lin TM. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. Transl Res 2007; 150:311-8.
13. Oh DY, Taube S, Hamouda O et al. A functional toll-like receptor 8 variant is associated with HIV disease restriction. J Infect Dis 2008; 198:701-9.
14. Davila S, Hibberd ML, Hari Dass R et al. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet 2008; 4:e1000218.
15. Moller-Larsen S, Nyegaard M, Haagerup A, Vestbo J, Kruse TA, Borglum AD. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax 2008; 63:1064-9.
16. Wang CH, Eng HL, Lin KH, Chang CH, Hsieh CA, Lin YL, Lin TM. TLR7 and TLR8 gene variations and susceptibility to hepatitis C virus infection. PLoS ONE 2011; 6:e26235.
17. Gorden KB, Gorski KS, Gibson SJ et al. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol 2005; 174:1259-68.
18. Rauch A, Gaudieri S, Thio C, Bochud PY. Host genetic determinants of spontaneous hepatitis C clearance. Pharmacogenomics 2009; 10:1819-37.
19. Chung H, Watanabe T, Kudo M, Chiba T. Correlation between hyporesponsiveness to Toll-like receptor ligands and liver dysfunction in patients with chronic hepatitis C virus infection. J Viral Hepat 2011; 18:e561-7.
20. + T cells in chronic hepatitis C virus infection. J Immunol 2002; 169:3447-58.
21. Thomas A, Laxton C, Rodman J, Myangar N, Horscroft N, Parkinson T. Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. Antimicrob Agents Chemother 2007; 51:2969-78.
22. Wang XQ, Rothnagel JA. 5'-untranslated regions with multiple upstream AUG codons can support low-level translation via leaky scanning and reinitiation. Nucleic Acids Res 2004; 32:1382-91.
23. Campbell GR, Spector SA. Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1. PLoS Pathog 2012; 8:e1003017.
24. Nian H, Geng WQ, Cui HL et al. R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes. BMC Infect Dis 2012; 12:5.
25. + T cells via suppression of dendritic cell IL-12 production. J Leukoc Biol 2007; 82:1407-19.
26. Liu BS, Groothuismink ZM, Janssen HL, Boonstra A. Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections. J Leukoc Biol 2011; 89:981-8.
27. Zhang Y, Ma CJ, Ni L et al. Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection. J Immunol 2011; 186:3093-103.
28. Tacke RS, Tosello-Trampont A, Nguyen V, Mullins DW, Hahn YS. Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. J Biol Chem 2011; 286:10847-55.