Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry-activity-based protein profiling

Biochemistry

Volumn 52, Issue 51, 2013, Pages 9187-9201

  Ward, Jessica ^a   Spath, Samantha N ^a   Pabst, Brandon ^a   Carpino, Philip A ^a   Ruggeri, Roger B ^a   Xing, Gang ^a   Speers, Anna E ^b   Cravatt, Benjamin F ^b   Ahn, Kay ^a  

^a PFIZER INC   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ION EXCHANGE; PORPHYRINS; PROTEINS; RATE CONSTANTS;

HYPOCHLOROUS ACIDS; INACTIVATION KINETICS; IRREVERSIBLE INACTIVATION; PROSTHETIC GROUPS; PROTEIN PROFILING; SECOND-ORDER RATE CONSTANTS; THERAPEUTIC TARGETS; TWO-STEP MECHANISMS;

BIOSYNTHESIS;

2 THIOXANTHINE MYELOPEROXIDASE INHIBITOR; ALKYNE; ENZYME; HYPOCHLOROUS ACID; ION CHANNEL; MYELOPEROXIDASE; UNCLASSIFIED DRUG; 3-(2-ETHOXYPROPYL)-2-THIOXO-2,3-DIHYDRO-1H-PURIN-6(9H)-ONE; AMPLEX RED REAGENT; ENZYME INHIBITOR; HYDROGEN PEROXIDE; OXAZINE DERIVATIVE; PEROXIDASE; PRODRUG; PROTEOME; THIOKETONE; XANTHINE DERIVATIVE; 3 (2 ETHOXYPROPYL) 2 THIOXO 2,3 DIHYDRO 1H PURIN 6(9H) ONE;

ARTICLE; CATALYSIS; CLICK CHEMISTRY; KINETICS; PRIORITY JOURNAL; PROTEIN STRUCTURE; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; HUMAN; LIVER; METABOLISM; SOLUBILITY; SYNTHESIS; DRUG ANTAGONISM;

ALKYNES; BINDING, COMPETITIVE; BIOCATALYSIS; CLICK CHEMISTRY; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; KINETICS; LIVER; OXAZINES; PEROXIDASE; PRODRUGS; PROTEOME; SOLUBILITY; THIONES; XANTHINES;

EID: 84895777018     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401354d     Document Type: Article

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