Decreased peripheral natural killer cells activity in the immune activated stage of chronic hepatitis B

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Li, Yuan ^a,b   Wang, Jiu Jun ^a   Gao, Shan ^a   Liu, Qian ^a   Bai, Jia ^a   Zhao, Xue Qi ^a   Hao, You Hua ^a   Ding, Hong Hui ^a   Zhu, Fan ^a   Yang, Dong Liang ^a   Zhao, Xi Ping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HEPATITIS B(E) ANTIGEN; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR NKG2D; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HEPATITIS B; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNITY; IMMUNOLOGICAL TOLERANCE; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; VIRUS LOAD;

ALANINE TRANSAMINASE; CYTOTOXICITY, IMMUNOLOGIC; DNA, VIRAL; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; IMMUNITY; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LIVER; LYMPHOCYTE SUBSETS; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; VIRUS REPLICATION;

EID: 84895773844     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086927     Document Type: Article

References (39)

1. Lok AS, McMahon BJ (2001) Practice guidelines committee, American Association for the Study of Liver Diseases. Chronic hepatitis B. Hepatology 34:1225-1241.
2. Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5:215-229. (Pubitemid 40364823)
3. Ganem D, Prince AM (2004) Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 350:1118-1129. (Pubitemid 38298992)
4. Tian Z, Chen Y, Gao B (2013) Natural killer cells in liver disease. Hepatology 57:1564-1662.
5. Sprengers D, van der Molen RG, Kusters JG, Hansen B, Niesters HG, et al. (2006) Different composition of intrahepatic lymphocytes in the immunetolerance and immune-clearance phase of chronic hepatitis B. J Med Virol 78:561-568.
6. Zou Z, Xu D, Li B, Xin S, Zhang Z, et al. (2009) Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure. Hepatol Res 39:1198-1207.
7. Rehermann B (2013)Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells. Nat Med 19:859-68.
8. Mondelli MU, Varchetta S, Oliviero B (2010) Natural killer cells in viral hepatitis: facts and controversies. Eur J Clin Invest 40:851-863.
9. Zhao J, Li Y, Jin L, Zhang S, Fan R, et al. (2012) Natural killer cells are characterized by the concomitantly increased interferon-c and cytotoxicity in acute resolved hepatitis B patients. PLoS One 7:e49135.
10. Webster GJ, Reignat S, Maini MK, Whalley SA, Ogg GS, et al. (2000) Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 32:1117-1124.
11. Fisicaro P, Valdatta C, Boni C, Massari M, Mori C, et al. (2009) Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 58:974-982.
12. Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, et al. (2013) Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J Exp Med 210:99-114.
13. Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, et al. (2007) Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med 204:667-680. (Pubitemid 46457088)
14. Zou Y, Chen T, Han M, Wang H, Yan W, et al. (2010) Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. J Immunol 184:466-475.
15. Lanier LL (2001) On guard-activating NK cell receptors. Nat Immunol 2:23-27.
16. Iwaszko M, Bogunia-Kubik K (2011) Clinical significance of the HLA-E and CD94/NKG2 interaction. Arch Immunol Ther Exp (Warsz) 59:353-367.
17. Peppa D, Micco L, Javaid A, Kennedy PT, Schurich A, et al. (2010) Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. PLoS Pathog 6:e1001227.
18. Sun C, Fu B, Gao Y, Liao X, Sun R, et al. (2012) TGF-b1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathog 8:e1002594.
19. Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ, et al. (2008) Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Gut 57:l121-l128.
20. Zarife MA, Reis EA, Carmo TM, Lopes GB, Brandão EC, et al. (2009) Increased frequency of CD56 (bright) NK-cells, CD3-CDl6+CD56-NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CD25 high T-cells control potentially viremia in blood donors with HCV. J Med Virol 81:49-59.
21. Mantegani P, Tambussi G, Galli L, Din CT, Lazzarin A, et al. (2010) Perturbation of the natural killer cell compartment during primary human immunodeficiency virus l infection primarily involving the CD56(bright) subset. Immunology 129:220-233.
22. Tseng CT, Klimpel GR (2002) Binding of the hepatitis C virus envelope protein E2 to CD8l inhibits natural killer cell functions. J Exp Med 195:43-49.
23. Oliviero B, Varchetta S, Paudice E, Michelone G, Zaramella M, et al. (2009) Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Gastroenterology 137:1151-1160.
24. Zhang Z, Zhang S, Zou Z, Shi J, Zhao J, et al. (2011) Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients. Hepatology 53:73-85.
25. Zhao PW, Jia FY, Shan YX, Ji HF, Feng JY, et al. (2013) Downregulation and altered function of natural killer cells in hepatitis B virus patients treated with entecavir. Clin Exp Pharmacol Physiol 40:190-196.
26. Tjwa ET, van Oord GW, Hegmans JP, Janssen HL, Woltman AM (2011) Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B. J Hepatol 54:209-218.
27. Mondelli MU, Oliviero B, Mele D, Mantovani S, Gazzabin C, et al. (2012) Natural killer cell functional dichotomy: a feature of chronic viral hepatitis? Front Immunol 3:351.
28. Lai CL, Yuen MF (2007) The natural history of chronic hepatitis B. J Viral Hepatol 14:6-10.
29. Lok AS, McMahon BJ (2007) Chronic hepatitis B. Hepatology 45:507-539. (Pubitemid 46374607)
30. Kakimi K, Guidotti LG, Koezuka Y, Chisari FV (2000) Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med 192:921-930.
31. + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy. J Virol 78:5707-5719.
32. Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S (2008) Functions of natural killer cells. Nat Immunol 9:503-510. (Pubitemid 351560519)
33. Rehermann B, Naoumov NV (2007) Immunological techniques in viral hepatitis. J Hepatol 46:508-520. (Pubitemid 46185711)
34. Nattermann J, Feldmann G, Ahlenstiel G, Langhans B, Sauerbruch T, et al. (2006) Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut 55: 869-877. (Pubitemid 43764560)
35. Meier UC, Owen RE, Taylor E, Worth A, Naoumov N, et al. (2005) Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections. J Virol 79:12365-12374. (Pubitemid 41346098)
36. Morishima C, Paschal DM, Wang CC, Yoshihara CS, Wood BL, et al. (2006) Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing. Hepatology 43:573-580.
37. Dunn C, Peppa D, Khanna P, Nebbia G, Jones M, et al. (2009) Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 137:1289-1300.
38. Alter G, Teigen N, Ahern R, Streeck H, Meier A, et al. (2007) Evolution of innate and adaptive effector cell functions during acute HIV-1 infection. J Infect Dis 195:1452-1460. (Pubitemid 46717463)
39. Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, et al. (1999) Viral clearance without destruction of infected cells during acute HBV infection. Science 284:825-829. (Pubitemid 29291352)