Determination of bicuculline in rat plasma by liquid chromatography mass spectrometry and its application in a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 953-954, Issue 1, 2014, Pages 143-146

  Ma, Jianshe ^a   Lin, Chongliang ^b   Wen, Congcong ^a   Xiang, Zheng ^a   Yang, Xuezhi ^b   Wang, Xianqin ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Bicuculline; LC MS; Pharmacokinetics; Rat plasma

Indexed keywords

ACETONITRILE; AMINO ACIDS; BODY FLUIDS; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; PHARMACOKINETICS;

BICUCULLINE; CHROMATOGRAPHIC SEPARATIONS; ELECTROSPRAY IONIZATION (ESI); GAMMA-AMINOBUTYRIC ACIDS; LC-MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; RAT PLASMA; SELECTIVE ION MONITORING;

LIQUID CHROMATOGRAPHY;

ACETONITRILE; BICUCULLINE; FORMIC ACID; METHANOL; MIDAZOLAM; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY; ION MONITORING; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RAT; ROOM TEMPERATURE;

BICUCULLINE; LC-MS; PHARMACOKINETICS; RAT PLASMA;

ANIMALS; BICUCULLINE; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; LIMIT OF DETECTION; LINEAR MODELS; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 84895771394     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.02.006     Document Type: Article

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