The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer

PLoS Computational Biology

Volumn 10, Issue 2, 2014, Pages

  Acuner Ozbabacan, Saliha Ece ^a   Gursoy, Attila ^a   Nussinov, Ruth ^b,c   Keskin, Ozlem ^a  

^a KOÇ UNIVERSITY   (Turkey)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELL DEATH; COMPLEXATION; DISEASES; PATHOLOGY;

CHRONIC INFLAMMATION; CYTOKINES; INNATE IMMUNITY; INTERFACE REGIONS; INTERLEUKIN1; ONCOGENICS; PROTEIN-PROTEIN COMPLEXES; SIGNALLING PATHWAYS; SINGLE NUCLEOTIDE POLYMORPHISMS; TUMOR DEVELOPMENT;

PROTEINS;

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 1 RECEPTOR TYPE I; MITOGEN ACTIVATED PROTEIN KINASE 10; MITOGEN ACTIVATED PROTEIN KINASE 9; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; IL1R1 PROTEIN, HUMAN; IL1RAP PROTEIN, HUMAN; MAP2K4 PROTEIN, HUMAN; MAP2K7 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CARCINOGENESIS; COMPLEX FORMATION; COMPUTER MODEL; COMPUTER PREDICTION; CONTROLLED STUDY; GENETIC ALGORITHM; IL 1 GENE; INFLAMMATION; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR MODEL; MUTATIONAL ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; BIOLOGICAL MODEL; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MUTAGENESIS; MUTATION; NEOPLASM; ONCOGENE;

COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HUMANS; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; MAP KINASE KINASE 4; MAP KINASE KINASE 7; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASE 9; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; NEOPLASMS; ONCOGENES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN INTERACTION MAPS; RECEPTORS, INTERLEUKIN-1 TYPE I; SIGNAL TRANSDUCTION;

EID: 84895765208     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003470     Document Type: Article

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