The pro-coagulant fibrinogenolytic serine protease isoenzymes purified from Daboia russelii russelii venom coagulate the blood through factor V activation: Role of glycosylation on enzymatic activity

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Mukherjee, Ashis K ^a,b  

^a TEZPUR UNIVERSITY   (India)

^b UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLARGININE ETHYL ESTER; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5; FIBRINOGEN; ISOENZYME; PLASMIN; RUSSELL VIPER FACTOR V PROTEASE ALPHA; RUSSELL VIPER FACTOR V PROTEASE BETA; RUSSELL VIPER FACTOR V PROTEASE DELTA; RUSSELL VIPER FACTOR V PROTEASE GAMMA; SERINE PROTEINASE; THROMBIN; TOSYLARGININE METHYL ESTER; TRYPSIN; UNCLASSIFIED DRUG; VIPER VENOM;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; DABOIA RUSSELLII; DEGLYCOSYLATION; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME MECHANISM; FIBRINOGEN METABOLISM; FIBRINOGENOLYSIS; GECKO; HEMIDACTYLUS FRENATUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIZARD; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ACTIVATION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; THROMBOSIS;

AMIDES; AMINO ACID SEQUENCE; ANIMALS; BLOOD COAGULATION; CARBOXYLIC ESTER HYDROLASES; CATTLE; CHROMOGENIC COMPOUNDS; COAGULANTS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR VA; FIBRINOGEN; GLYCOSYLATION; ISOENZYMES; MICE; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; RUSSELL'S VIPER; SEQUENCE ALIGNMENT; SERINE PROTEASES; VIPER VENOMS;

EID: 84895744919     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086823     Document Type: Article

References (30)

1. Warrell DA (1989) Snake venoms in science and clinical medicine. 1. Russell's viper: biology, venom and treatment of bites. Trans. R. Soc. Trop. Med. Hyg83: 732-740
2. Mukherjee AK, Ghosal SK, Maity CR (2000) Some biochemical properties of Russell's viper (Daboia russelli) venom from Eastern India: correlation with clinical pathological manifestation in Russell's viper bite. Toxicon38: 163-175 (Pubitemid 29512189)
3. Gutierrez JM, Williams D, Fan HW, Warrell DA (2010) Snakebite envenoming from a global perspective: Towards an integrated approach. Toxicon 56: 1223-1235.
4. Wuster W, Otsula S, Malhotra A, Thorpe RS (1992) Population systematics of Russell's viper: a multivariate study. Biol. J. Linnean Society 47:97-113. (Pubitemid 24409865)
5. Swenson S, Markland Jr FS (2005) Snake venom fibrin(ogen)olytic enzymes. Toxicon 45: 1021-1039. (Pubitemid 40732578)
6. Mukherjee AK (2008) Characterization of a novel pro-coagulant metalloprotease (RVBCMP) possessing α-fibrinogenase and tissue hemorrhagic activity from venom of Daboia russelii russelii (Russell's Viper): evidence of distinct coagulant and hemorrhagic sites in RVBCMP. Toxicon 51: 923-933
7. Mukherjee AK, Mackessy SP (2013) Biochemical and pharmacological properties of a new thrombin-like serine protease (Russelobin) from the venom of Russell's viper (Daboia russelii russelii) and assessment of its therapeutic potential. Bichem. Biophys. Acta-Gen. Sub 1830: 3476-3488
8. Serrano SMT, Maroun RC (2005) Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved. Toxicon 45:1115-1132 (Pubitemid 40732585)
9. Di Scipio RG, Hermodson MA, Davie EW (1977) Activation of human factor X (Stuart factor) by a protease from Russell's viper venom. Biochemistry 16: 5253-5260. (Pubitemid 8241844)
10. Kisiel W (1979) Molecular properties of the factor V-activating enzyme from Russell's viper venom. J. Biol. Chem254: 12230-12234
11. Serrano SM, Hagiwara Y, Murayama N, Higuchi S, Mentele R, et al. (1998) Purification and characterization of a kinin-releasing and fibrinogen-clotting serine proteinase (KN-BJ) from the venom of Bothrops jararaca, and molecular cloning and sequence analysis of its cDNA. Eur. J. Biochem251: 845-853. (Pubitemid 28108981)
12. Patiño AC, Pereañez JA, Gutiérrez JM, Rucavado A (2013) Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom. Toxicon 63: 32-43
13. Siigur E, Samel M, Tonismagi K, Subbi J, Reintamm T, et al. (1998) Properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom. Biochim. Biophys. Acta 1429: 239-248 (Pubitemid 29052223)
14. Mukherjee AK, Rai SK, Thakur R, Chattopadhyay P, Kar SK (2012) Bafibrinase: A non-toxic, non-hemorrhagic, direct-acting fibrinolytic serine protease from Bacillus sp. strain AS-S20-I exhibits in vivo anticoagulant activity and thrombolytic potency. Biochimie 94: 1300-1308
15. Weldon CL, Mackessy SP (2012) Alsophinase, a new P-III metalloproteinase with α-fibrinogenolytic and hemorrhagic activity from the venom of the rear-fanged Puerto Rican Racer Alsophisporto ricensis (Serpentes: Dipsadidae) Biochimie94: 1189-1198
16. Monkovic DD, Tracy PB (1990). Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin. J Biol. Chem265: 17132-17140.
17. Gerads I, Tans G, Yukelson LY, Zaal RF, Rosing J (1992) Activation of bovine factor V by an activator purified from the venom of Naja naja oxiana. Toxicon 30: 1065-1079.
18. Dubois M, Giles KA, Hamiltion JK, Rebers PA, Smith F (1956) Colorimetric method for determination of sugars and related substances. Anal. Chem28: 350-356
19. Burmester HBC, Aulton K, Horsfield GI (1970) Evaluation of a rapid method for the determination of plasma fibrinogen. J.Clin. Path23: 43-46.
20. Nesheim ME, Taswell JB, Mann KG (1979) The contribution of bovine factor V and bovine factor Va to the activity of prothrombinase. J Biol. Chem254: 10354-10361
21. Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, et al. (1988) The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences. J. Biol. Chem263: 17471-17481 (Pubitemid 19029331)
22. Amiconi G, Amoresano A, Boumis G, Brancaccio A, DeCristofaro R, et al. (2000) A novel venombin B from Agkistrodon contortrix contortrix: evidence for recognition properties in the surface around the primary specificity pocket different from thrombin. Biochemistry 39: 10294-10308. (Pubitemid 30663052)
23. Serrano SM, Matos MF, Mandelbaum FR, Sampaio CA (1993) Basic proteinases from Bothrops moojeni (caissaca) venome. I. Isolation and activity of two serine proteinases, MSP 1 and MSP 2, on synthetic substrates and on platelet aggregation. Toxicon 31: 471-481.
24. Deshimaru M, Ogawa T, Nakashima K, Nobuhisa I, Chijiwa T, et al. (1996) Accelerated evolution of crotalinae snake venom gland serine proteases. FEBS Lett397: 83-88. (Pubitemid 26380179)
25. Menaldo DL, Bernardes CP, Santos-Filho NA, Moura LA, Fuly AC, et al. (2012) Biochemical characterization and comparative analysis of two distinct serine proteases from Bothrops pirajai snake venom. Biochimie 94: 2545-2558.
26. Mukherjee AK (2013), An updated inventory on properties, pathophysiology and therapeutic potential of snake venom thrombin-like proteases, In: S. Chakraborti, N.S. Dhalla, (Eds.), Proteases in Health and Disease-Advances in Biochemistry in Health and Disease Volume 7 (ISBN 978-1-4614-9233-7), Springer, pp.163-180.
27. Reichel AP, Serrano SMT, Sampaio CAM, Mandelbaum FR (1993) Hydrolytic specificity of three basic proteinases isolated from the venom of Bothrpos moojeni for the B-chain of oxidized insulin. Toxicon 31: 1479-1482.
28. Oyama E, Takahashi H (2003) Purification and characterization of a thrombin like enzyme, elegaxobin II, with lys-bradykinin releasing activity from the venom of Trimeresurus elegans (Sakishima-Habu). Toxicon 4: 559-568. (Pubitemid 36379294)
29. 2) and kaouthiotoxin (KTX) from venom of Naja kaouthia exhibits marked synergism to potentiate their cytotoxicity on target cells. J. Venom Res1: 37-42
30. Markland FS (1996) Fibrolase, an active thrombolytic enzyme in arterial and venous thrombosis model systems. Adv. Exp. Med.Biol391: 427-438.