메뉴 건너뛰기




Volumn 75, Issue 4, 2014, Pages 330-337

Inter-relation of Th1, Th2, Th17 and Treg cytokines in oral cancer patients and their clinical significance

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84895560831     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2014.01.011     Document Type: Article
Times cited : (50)

References (46)
  • 1
    • 84895542405 scopus 로고    scopus 로고
    • GLOBOCAN 2008 v1.2, cancer incidence and mortality worldwide: IARC cancer base No. 10 (Lyon, France: International agency for research on cancer, 2010). available from: [accessed 25.04.13].
    • Ferlay J, Shin HR, Bray F, Forman D, Mathers D, Parkin DM. GLOBOCAN 2008 v1.2, cancer incidence and mortality worldwide: IARC cancer base No. 10 (Lyon, France: International agency for research on cancer, 2010). available from: 2013 [accessed 25.04.13]. http://globocan.iarc.fr.
    • (2013)
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, D.5    Parkin, D.M.6
  • 3
    • 0036143705 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 as a useful serologic marker of small hepatocellular carcinoma
    • Song B.-C., Chung Y.-H., Kim J.A., Choi W.-B., Suh D.D., Pyo S.I., et al. Transforming growth factor-beta1 as a useful serologic marker of small hepatocellular carcinoma. Cancer 2002, 94:175-180.
    • (2002) Cancer , vol.94 , pp. 175-180
    • Song, B.-C.1    Chung, Y.-H.2    Kim, J.A.3    Choi, W.-B.4    Suh, D.D.5    Pyo, S.I.6
  • 4
    • 10044261013 scopus 로고    scopus 로고
    • Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis
    • Ebrahimi B., Tucker S.L., Li D., Abbruzzese J.L., Kurzrock R. Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer 2004, 101:2727-2736.
    • (2004) Cancer , vol.101 , pp. 2727-2736
    • Ebrahimi, B.1    Tucker, S.L.2    Li, D.3    Abbruzzese, J.L.4    Kurzrock, R.5
  • 5
    • 14744281867 scopus 로고    scopus 로고
    • Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients
    • Hathaway B., Landsittel D.P., Gooding W., Whiteside T.L., Grandis J.R., Siegfried J.M., et al. Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients. Laryngoscope 2005, 115:522-527.
    • (2005) Laryngoscope , vol.115 , pp. 522-527
    • Hathaway, B.1    Landsittel, D.P.2    Gooding, W.3    Whiteside, T.L.4    Grandis, J.R.5    Siegfried, J.M.6
  • 6
    • 43849092649 scopus 로고    scopus 로고
    • Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma
    • Nacinović-Duletić A., Stifter S., Dvornik S., Skunca Z., Jonjić N. Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma. Int J Lab Hematol 2008, 30:230-239.
    • (2008) Int J Lab Hematol , vol.30 , pp. 230-239
    • Nacinović-Duletić, A.1    Stifter, S.2    Dvornik, S.3    Skunca, Z.4    Jonjić, N.5
  • 7
    • 84870847993 scopus 로고    scopus 로고
    • Elevated pretherapy serum IL17 in primary hepatocellular carcinoma patients correlate to increased risk of early recurrence after curative hepatectomy
    • Wu J., Du J., Liu L., Li Q., Rong W., Wang L., et al. Elevated pretherapy serum IL17 in primary hepatocellular carcinoma patients correlate to increased risk of early recurrence after curative hepatectomy. PLoS One 2012, 7:e50035.
    • (2012) PLoS One , vol.7
    • Wu, J.1    Du, J.2    Liu, L.3    Li, Q.4    Rong, W.5    Wang, L.6
  • 8
    • 3843142873 scopus 로고    scopus 로고
    • Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma
    • St John M.A., Li Y., Zhou X., Denny P., Ho C.-M., Montemagno C., et al. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2004, 130:929-935.
    • (2004) Arch Otolaryngol Head Neck Surg , vol.130 , pp. 929-935
    • St John, M.A.1    Li, Y.2    Zhou, X.3    Denny, P.4    Ho, C.-M.5    Montemagno, C.6
  • 9
    • 84895543018 scopus 로고    scopus 로고
    • Cytokines
    • Kenneth Murphy Taylor and Francis group, LLC, London and New York, Immuno biology
    • Kenneth Murphy Cytokines. Garland Sciences 2012, Taylor and Francis group, LLC, London and New York.
    • (2012) Garland Sciences
  • 10
    • 0026570853 scopus 로고
    • IL-10 inhibits human T cell proliferation and IL-2 production
    • Taga K., Tosato G. IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 1992, 148:1143-1148.
    • (1992) J Immunol , vol.148 , pp. 1143-1148
    • Taga, K.1    Tosato, G.2
  • 11
    • 0030950036 scopus 로고    scopus 로고
    • Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules
    • Yue F.Y., Dummer R., Geertsen R., Hofbauer G., Laine E., Manolio S., et al. Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules. Int J Cancer 1997, 71:630-637.
    • (1997) Int J Cancer , vol.71 , pp. 630-637
    • Yue, F.Y.1    Dummer, R.2    Geertsen, R.3    Hofbauer, G.4    Laine, E.5    Manolio, S.6
  • 12
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
    • De Waal Malefyt R., Abrams J., Bennett B., Figdor C.G., de Vries J.E. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991, 174:1209-1220.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    de Vries, J.E.5
  • 13
    • 0025889036 scopus 로고
    • Macrophage deactivation by interleukin 10
    • Bogdan C., Vodovotz Y., Nathan C. Macrophage deactivation by interleukin 10. J Exp Med 1991, 174:1549-1555.
    • (1991) J Exp Med , vol.174 , pp. 1549-1555
    • Bogdan, C.1    Vodovotz, Y.2    Nathan, C.3
  • 14
    • 34848857434 scopus 로고    scopus 로고
    • Transforming growth factor-beta and the immune response: implications for anticancer therapy
    • Wrzesinski S.H., Wan Y.Y., Flavell R.A. Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin Cancer Res 2007, 13:5262-5270.
    • (2007) Clin Cancer Res , vol.13 , pp. 5262-5270
    • Wrzesinski, S.H.1    Wan, Y.Y.2    Flavell, R.A.3
  • 15
    • 33845524970 scopus 로고    scopus 로고
    • Transforming growth factor-beta in cancer and metastasis
    • Jakowlew S.B. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev 2006, 25:435-457.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 435-457
    • Jakowlew, S.B.1
  • 16
    • 70449715722 scopus 로고    scopus 로고
    • Protumor vs antitumor functions of IL-17
    • Murugaiyan G., Saha B. Protumor vs antitumor functions of IL-17. J Immunol 2009, 183:4169-4175.
    • (2009) J Immunol , vol.183 , pp. 4169-4175
    • Murugaiyan, G.1    Saha, B.2
  • 17
    • 48849103649 scopus 로고    scopus 로고
    • Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing
    • Sfanos K.S., Bruno T.C., Maris C.H., Xu L., Thoburn C.J., DeMarzo A.M., et al. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res 2008, 14:3254-3261.
    • (2008) Clin Cancer Res , vol.14 , pp. 3254-3261
    • Sfanos, K.S.1    Bruno, T.C.2    Maris, C.H.3    Xu, L.4    Thoburn, C.J.5    DeMarzo, A.M.6
  • 18
    • 58149234402 scopus 로고    scopus 로고
    • Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage
    • Koyama K., Kagamu H., Miura S., Hiura T., Miyabayashi T., Itoh R., et al. Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage. Clin Cancer Res 2008, 14:6770-6779.
    • (2008) Clin Cancer Res , vol.14 , pp. 6770-6779
    • Koyama, K.1    Kagamu, H.2    Miura, S.3    Hiura, T.4    Miyabayashi, T.5    Itoh, R.6
  • 19
    • 69849107597 scopus 로고    scopus 로고
    • Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
    • Kryczek I., Banerjee M., Cheng P., Vatan L., Szeliga W., Wei S., et al. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 2009, 114:1141-1149.
    • (2009) Blood , vol.114 , pp. 1141-1149
    • Kryczek, I.1    Banerjee, M.2    Cheng, P.3    Vatan, L.4    Szeliga, W.5    Wei, S.6
  • 22
    • 84870050796 scopus 로고    scopus 로고
    • Skewed immunological balance between Th17 (CD4(+)IL17A (+)) and Treg (CD4 (+)CD25 (+)FOXP3 (+)) cells in human oral squamous cell carcinoma
    • Gaur P., Qadir G.A., Upadhyay S., Singh A.K., Shukla N.K., Das S.N. Skewed immunological balance between Th17 (CD4(+)IL17A (+)) and Treg (CD4 (+)CD25 (+)FOXP3 (+)) cells in human oral squamous cell carcinoma. Cell Oncol (Dordr) 2012, 35:335-343.
    • (2012) Cell Oncol (Dordr) , vol.35 , pp. 335-343
    • Gaur, P.1    Qadir, G.A.2    Upadhyay, S.3    Singh, A.K.4    Shukla, N.K.5    Das, S.N.6
  • 23
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • Zhou L., Lopes J.E., Chong M.M.W., Ivanov I.I., Min R., Victora G.D., et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008, 453:236-240.
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.W.3    Ivanov, I.I.4    Min, R.5    Victora, G.D.6
  • 24
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357:539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 27
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel N., Unutmaz D., Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008, 9:641-649.
    • (2008) Nat Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 29
    • 34249806717 scopus 로고    scopus 로고
    • Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
    • Kryczek I., Wei S., Zou L., Altuwaijri S., Szeliga W., Kolls J., et al. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol 2007, 178:6730-6733.
    • (2007) J Immunol , vol.178 , pp. 6730-6733
    • Kryczek, I.1    Wei, S.2    Zou, L.3    Altuwaijri, S.4    Szeliga, W.5    Kolls, J.6
  • 30
    • 84880265689 scopus 로고    scopus 로고
    • Expression of interleukin-17 and its clinical significance in gastric cancer patients
    • Meng X.Y., Zhou C.H., Ma J., Jiang C., Ji P. Expression of interleukin-17 and its clinical significance in gastric cancer patients. Med Oncol 2012, 29:3024-3028.
    • (2012) Med Oncol , vol.29 , pp. 3024-3028
    • Meng, X.Y.1    Zhou, C.H.2    Ma, J.3    Jiang, C.4    Ji, P.5
  • 32
    • 0028902318 scopus 로고
    • Elevated plasma levels of TGF-beta 1 in patients with invasive prostate cancer
    • Ivanovic V., Melman A., Davis-Joseph B., Valcic M., Geliebter J. Elevated plasma levels of TGF-beta 1 in patients with invasive prostate cancer. Nat Med 1995, 1:282-284.
    • (1995) Nat Med , vol.1 , pp. 282-284
    • Ivanovic, V.1    Melman, A.2    Davis-Joseph, B.3    Valcic, M.4    Geliebter, J.5
  • 33
    • 0034911060 scopus 로고    scopus 로고
    • Serum levels of transforming growth factor beta1 in patients with breast cancer
    • Sheen-Chen S.M., Chen H.S., Sheen C.W., Eng H.L., Chen W.J. Serum levels of transforming growth factor beta1 in patients with breast cancer. Arch Surg 2001, 136:937-940.
    • (2001) Arch Surg , vol.136 , pp. 937-940
    • Sheen-Chen, S.M.1    Chen, H.S.2    Sheen, C.W.3    Eng, H.L.4    Chen, W.J.5
  • 34
    • 0006335227 scopus 로고    scopus 로고
    • Elevated serum levels of transforming growth factor-beta1 in patients with colorectal carcinoma: its association with tumor progression and its significant decrease after curative surgical resection
    • Shim K.S., Kim K.H., Han W.S., Park E.B. Elevated serum levels of transforming growth factor-beta1 in patients with colorectal carcinoma: its association with tumor progression and its significant decrease after curative surgical resection. Cancer 1999, 85:554-561.
    • (1999) Cancer , vol.85 , pp. 554-561
    • Shim, K.S.1    Kim, K.H.2    Han, W.S.3    Park, E.B.4
  • 35
    • 77951820013 scopus 로고    scopus 로고
    • Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma
    • Sharma A., Khan R., Joshi S., Kumar L., Sharma M. Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma. Leuk Lymphoma 2010, 51:920-927.
    • (2010) Leuk Lymphoma , vol.51 , pp. 920-927
    • Sharma, A.1    Khan, R.2    Joshi, S.3    Kumar, L.4    Sharma, M.5
  • 36
    • 33646410446 scopus 로고    scopus 로고
    • Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors
    • Inagaki A., Ishida T., Ishii T., Komatsu H., Iida S., Ding J., et al. Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors. Int J Cancer 2006, 118:3054-3061.
    • (2006) Int J Cancer , vol.118 , pp. 3054-3061
    • Inagaki, A.1    Ishida, T.2    Ishii, T.3    Komatsu, H.4    Iida, S.5    Ding, J.6
  • 38
    • 0038712135 scopus 로고    scopus 로고
    • Dys-regulated expression of TH2 cytokine gene in patients with intraoral squamous cell carcinoma
    • Agarwal A., Rani M., Saha G.K., Valarmathi T.M., Bahadur S., Mohanti B.K., et al. Dys-regulated expression of TH2 cytokine gene in patients with intraoral squamous cell carcinoma. Immunol Invest 2003, 32:17-30.
    • (2003) Immunol Invest , vol.32 , pp. 17-30
    • Agarwal, A.1    Rani, M.2    Saha, G.K.3    Valarmathi, T.M.4    Bahadur, S.5    Mohanti, B.K.6
  • 39
    • 33747444946 scopus 로고    scopus 로고
    • Differential regulation of IL-2 and IL-4 in patients with tobacco related oral squamous cell carcinoma
    • Manchanda P., Sharma S.C., Das S.N. Differential regulation of IL-2 and IL-4 in patients with tobacco related oral squamous cell carcinoma. Oral Dis 2006, 12:455-462.
    • (2006) Oral Dis , vol.12 , pp. 455-462
    • Manchanda, P.1    Sharma, S.C.2    Das, S.N.3
  • 40
    • 84864375715 scopus 로고    scopus 로고
    • Diagnostic and prognostic significance of prostate specific antigen and serum interleukin 18 and 10 in patients with locally advanced prostate cancer: a prospective study
    • Dwivedi S., Goel A., Natu S.M., Mandhani A., Khattri S., Pant K.K. Diagnostic and prognostic significance of prostate specific antigen and serum interleukin 18 and 10 in patients with locally advanced prostate cancer: a prospective study. Asian Pac J Cancer Prev 2011, 12:1843-1848.
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 1843-1848
    • Dwivedi, S.1    Goel, A.2    Natu, S.M.3    Mandhani, A.4    Khattri, S.5    Pant, K.K.6
  • 43
    • 77951167841 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 and interleukin-10 in Turkish patients with aggressive non-Hodgkin's lymphoma
    • Guney N., Soydinc H.O., Basaran M., Bavbek S., Derin D., Camlica H., et al. Serum levels of interleukin-6 and interleukin-10 in Turkish patients with aggressive non-Hodgkin's lymphoma. Asian Pac J Cancer Prev 2009, 10:669-674.
    • (2009) Asian Pac J Cancer Prev , vol.10 , pp. 669-674
    • Guney, N.1    Soydinc, H.O.2    Basaran, M.3    Bavbek, S.4    Derin, D.5    Camlica, H.6
  • 44
  • 45
    • 80052559068 scopus 로고    scopus 로고
    • Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians
    • Gaur P., Mittal M., Mohanti B.K., Das S.N. Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Oral Dis 2011, 17:720-726.
    • (2011) Oral Dis , vol.17 , pp. 720-726
    • Gaur, P.1    Mittal, M.2    Mohanti, B.K.3    Das, S.N.4
  • 46
    • 82255191747 scopus 로고    scopus 로고
    • Functional genetic variants of TGF-β1 and risk of tobacco-related oral carcinoma in high-risk Asian Indians
    • Gaur P., Mittal M., Mohanti B.K., Das S.N. Functional genetic variants of TGF-β1 and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Oral Oncol 2011, 14:1117-1121.
    • (2011) Oral Oncol , vol.14 , pp. 1117-1121
    • Gaur, P.1    Mittal, M.2    Mohanti, B.K.3    Das, S.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.