Skewed immunological balance between Th17 (CD4+IL17A +) and Treg (CD4+CD25+FOXP3+) cells in human oral squamous cell carcinoma

Cellular Oncology

Volumn 35, Issue 5, 2012, Pages 335-343

  Gaur, Poonam ^a   Qadir, Gulam Abdul ^a   Upadhyay, Shilpy ^a   Singh, Avadhesh Kumar ^a   Shukla, Nootan Kumar ^b   Das, Satya Narayan ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b INSTITUTE ROTARY CANCER HOSPITAL   (India)

Author keywords

Oral cancer; Tcell subsets; Th17; Tregs

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; LYMPH NODE METASTASIS; MALE; MOUTH SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH17 CELL;

ADULT; AGED; ANTIGENS, CD4; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CELL COUNT; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INDIA; INTERLEUKIN-17; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM STAGING; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84870050796     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-012-0093-5     Document Type: Article

References (36)

1. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, D.M. Parkin, GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10 (Lyon, France: International Agency for Research on Cancer, 2010). Available from: http:// globocan.iarc.fr. Accessed on 15 March 2012
2. M.C. Chang, C.P. Chiang, C.L. Lin, J.J. Lee, L.J. Hahn, J.H. Jeng, Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol. 41, 757-775 (2005) (Pubitemid 41140017)
3. S.N. Das, N.N. Khanna, S. Khanna, In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis. Cancer Invest. 4, 207-216 (1986) (Pubitemid 16005279)
4. T.P. Wustrow, C.G. Mahnke, Causes of immunosuppression in squamous cell carcinoma of the head and neck. Anticancer Res. 16, 2433-2468 (1996) (Pubitemid 26325426)
5. E.Y. Woo, H. Yeh, C.S. Chu, K. Schlienger, R.G. Carroll, J.L. Riley, L.R. Kaiser, C.H. June, Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. 168, 4272-4276 (2002) (Pubitemid 34441324)
6. U.K. Liyanage, T.T. Moore, H.G. Joo, Y. Tanaka, V. Herrmann, G. Doherty, J.A. Drebin, S.M. Strasberg, T.J. Eberlein, P.S. Goedegebuure, D.C. Linehan, Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756-2761 (2002) (Pubitemid 34921025)
7. A.M. Miller, K. Lundberg, V. Ozenci, A.H. Banham, M. Hellström, L. Egevad, P. Pisa, CD4+CD25high Tcells are enriched in the tumor and peripheral blood of prostate cancer patients. J. Immunol. 177, 7398-7405 (2006) (Pubitemid 44715110)
8. L.A. Ormandy, T. Hillemann, H. Wedemeyer, M.P. Manns, T.F. Greten, F. Korangy, Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res. 65, 2457-2464 (2005) (Pubitemid 40490158)
9. T.J. Curiel, G. Coukos, L. Zou, X. Alvarez, P. Cheng, P. Mottram, M. Evdemon-Hogan, J.R. Conejo-Garcia, L. Zhang, M. Burow, Y. Zhu, S. Wei, I. Kryczek, B. Daniel, A. Gordon, L. Myers, A. Lackner, M.L. Disis, K.L. Knutson, L. Chen, W. Zou, Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10, 942-949 (2004) (Pubitemid 39273735)
10. A. Bamias, V. Koutsoukou, E. Terpos, M.L. Tsiatas, C. Liakos, O. Tsitsilonis, A. Rodolakis, Z. Voulgaris, G. Vlahos, T. Papageorgiou, G. Papatheodoridis, A. Archimandritis, A. Antsaklis, M.A. Dimopoulos, Correlation of NK T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFalpha in ascites from advanced ovarian cancer: Association with platinum resistance and prognosis in patients receiving first-line, platinumbased chemotherapy. Gynecol. Oncol. 108, 421-427 (2008)
11. J. Shimizu, S. Yamazaki, S. Sakaguchi, Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163, 5211-5218 (1999)
12. I. Kryczek, M. Banerjee, P. Cheng, L. Vatan,W. Szeliga, S.Wei, E. Huang, E. Finlayson, D. Simeone, T.H. Welling, A. Chang, G. Coukos, R. Liu, W. Zou, Phenotype, distribution, generation, andfunctional and clinical relevance of Th17 cells in the human tumor environments. Blood 114, 1141-1149 (2009)
13. X. Su, J. Ye, E.C. Hsueh, Y. Zhang, D.F. Hoft, G. Peng, Tumor microenvironments direct the recruitment and expansion of human Th17 cells. J. Immunol. 184, 1630-1641 (2010)
14. J.P. Zhang, J. Yan, J. Xu, X.H. Pang, M.S. Chen, L. Li, C. Wu, S.P. Li, L. Zheng, Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 50, 980-989 (2009)
15. K.S. Sfanos, T.C. Bruno, C.H. Maris, L. Xu, C.J. Thoburn, A.M. DeMarzo, A.K. Meeker, W.B. Isaacs, C.G. Drake, Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin. Cancer Res. 14, 3254-3261 (2008)
16. K. Koyama, H. Kagamu, S. Miura, T. Hiura, T. Miyabayashi, R. Itoh, H. Kuriyama, H. Tanaka, J. Tanaka, H. Yoshizawa, K. Nakata, F. Gejyo, Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage. Clin. Cancer Res. 14, 6770-6779 (2008)
17. Z.Z. Yang, A.J. Novak, S.C. Ziesmer, T.E. Witzig, S.M. Ansell, Malignant B cells skew the balance of regulatory T cells and TH17 cells in B-cell non-Hodgkin's lymphoma. Cancer Res. 69, 5522-5530 (2009)
18. C. Horlock, B. Stott, P.J. Dyson, M. Morishita, R.C. Coombes, P. Savage, J. Stebbing, The effects of transtuzumab on the CD4+ CD25+FOXP3+ and CD4+IL17A+T-cell axis in patients with breast cancer. Br. J. Cancer 100, 1061-1067 (2009)
19. I. Kryczek, S. Wei, L. Zou, S. Altuwaijri, W. Szeliga, J. Kolls, A. Chang, W. Zou, Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J. Immunol. 178, 6730-6733 (2007) (Pubitemid 46847396)
20. E.S. Hwang, Transcriptional regulation of T helper 17 cell differentiation. Yonsei Med. J. 51, 484-491 (2010)
21. J. Lohr, B. Knoechel, D. Caretto, A.K. Abbas, Balance of Th1 and Th17 effector and peripheral regulatory T cells. Microbes Infect. 11, 589-593 (2009)
22. E. Bettelli, M. Oukka, V.K. Kuchroo, T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8, 345-350 (2007)
23. A. O'Garra, P. Vieira, Regulatory T cells and mechanisms of immune system control. Nat. Med. 10, 801-805 (2004) (Pubitemid 39070850)
24. C. Dong, TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8, 337-348 (2008) (Pubitemid 351595217)
25. A. Agarwal, M. Rani, G.K. Saha, T.M. Valarmathi, S. Bahadur, B.K. Mohanti, S.N. Das, Disregulated expression of the Th2 cytokine gene in patients with intraoral squamous cell carcinoma. Immunol. Invest. 32, 17-30 (2003) (Pubitemid 36527847)
26. C.S. Hinrichs, A. Kaiser, C.M. Paulos, L. Cassard, L. Sanchez-Perez, B. Heemskerk, C. Wrzesinski, Z.A. Borman, P. Muranski, N.P. Restifo, Type 17 CD8+ T cells display enhanced antitumor immunity. Blood 114, 596-599 (2009)
27. Y. Miyahara, K. Odunsi, W. Chen, G. Peng, J. Matsuzaki, R.F. Wang, Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc Natl Acad of Sci USA 105, 15505-15510 (2008)
28. J.J. Lee, Y.L. Chang, W.L. Lai, J.Y. Ko, M.Y. Kuo, C.P. Chiang, M. Azuma, C.W. Chen, J.S. Chia, Increased prevalence of interleukin-17-producing CD4(+) tumor infiltrating lymphocytes in human oral squamous cell carcinoma. Head Neck 33, 1301-1308 (2011)
29. P.Muranski,A. Boni, P.A. Antony, L. Cassard,K.R. Irvine, A. Kaiser, C.M. Paulos, D.C. Palmer, C.E. Touloukian, K. Ptak, L. Gattinoni, C. Wrzesinski, C.S. Hinrichs, K.W. Kerstann, L. Feigenbaum, C.C. Chan, N.P. Restifo, Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112, 362-373 (2008)
30. N. Martin-Orozco, P. Muranski, Y. Chung, X.O. Yang, T. Yamazaki, S. Lu, P. Hwu, N.P. Restifo, W.W. Overwijk, C. Dong, T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31, 787-798 (2009)
31. M. Numasaki, J. Fukushi, M. Ono, S.K. Narula, P.J. Zavodny, T. Kudo, P.D. Robbins, H. Tahara, M.T. Lotze, Interleukin-17 promotes angiogenesis and tumor growth. Blood 101, 2620-2627 (2003) (Pubitemid 36857622)
32. M. Pelletier, L. Maggi, A. Micheletti, E. Lazzeri, N. Tamassia, C. Costantini, L. Cosmi, C. Lunardi, F. Annunziato, S. Romagnani, M.A. Cassatella, Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 115, 335-343 (2010)
33. L.Wang, T. Yi, M. Kortylewski, D.M. Pardoll, D. Zeng, H. Yu, IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J. Exp. Med. 206, 1457-1464 (2009)
34. W. Zou, N.P. Restifo, T(H)17 cells in tumour immunity and immunotherapy. Nat. Rev. Immunol. 10, 248-256 (2010)
35. X.O. Yang, R. Nurieva, G.J. Martinez, H.S. Kang, Y. Chung, B.P. Pappu, B. Shah, S.H. Chang, K.S. Schluns, S.S. Watowich, X.H. Feng, A.M. Jetten, C. Dong, Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29, 44-56 (2008)
36. K.M. Elias, A. Laurence, T.S. Davidson, G. Stephens, Y. Kanno, E.M. Shevach, J.J. O'Shea, Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111, 1013-1020 (2008) (Pubitemid 351213378)