The PCDH1 gene and asthma in early childhood

European Respiratory Journal

Volumn 43, Issue 3, 2014, Pages 792-800

  Mortensen, Li J ^a   Kreiner Møller, Eskil ^a   Hakonarson, Hakon ^b   Bønnelykke, Klaus ^a   Bisgaard, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; ASTHMA; ATOPIC DERMATITIS; BRONCHUS HYPERREACTIVITY; CHILD; CHILDHOOD; COHORT ANALYSIS; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; GENOTYPE PHENOTYPE CORRELATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; MOTHER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTOCADHERIN 1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM; UNITED STATES;

ALLELES; ASTHMA; CADHERINS; CELL ADHESION; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; GENOTYPE; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; LONGITUDINAL STUDIES; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84895557669     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00021613     Document Type: Article

References (34)

1. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006; 355: 2226-2235.
2. Kocevar VS, Bisgaard H, Jonsson L, et al. Variations in pediatric asthma hospitalization rates and costs between and within nordic countries. Chest 2004; 125: 1680-1684.
3. Wiesch DG, Meyers DA, Bleecker ER. Genetics of asthma. J Allergy Clin Immunol 1999; 104: 895-901.
4. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. GINA, 2012. www. ginasthma.org/documents/4
5. Martinez FD, Wright AL, Taussig LM, et al. Asthma and wheezing in the first six years of life. The group health medical associates. N Engl J Med 1995; 332: 133-138.
6. Henderson J, Granell R, Heron J, et al. Associations of wheezing phenotypes in the first 1 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax 2008; 63: 974-980
7. Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211-1221.
8. Koppelman GH, Meyers DA, Howard TD, et al. Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med 2009; 180: 929-935.
9. Koning H, Postma DS, Brunekreef B, et al. Protocadherin-1 polymorphisms are associated with eczema in two dutch birth cohorts. Pediatr Allergy Immunol 2012; 23: 270-277.
10. Koning H, Sayers I, Stewart CE, et al. Characterization of protocadherin-1 expression in primary bronchial epithelial cells: Association with epithelial cell differentiation. FASEB J 2012; 26: 439-448.
11. Fitsialos G, Chassot AA, Turchi L, et al. Transcriptional signature of epidermal keratinocytes subjected to in vitro scratch wounding reveals selective roles for ERK1/2, p38, and phosphatidylinositol 3-kinase signaling pathways. J Biol Chem 2007; 282: 15090-15102.
12. Redies C, Vanhalst K, Roy F. Delta-protocadherins: unique structures and functions. Cell Mol Life Sci 2005; 62: 2840-2852.
13. Vanhalst K, Kools P, Staes K, et al. Delta-protocadherins: a gene family expressed differentially in the mouse brain. Cell Mol Life Sci 2005; 62: 1247-1259.
14. Wu Q, Maniatis T. A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 1999; 97: 779-790.
15. Redies C, Heyder J, Kohoutek T, et al. Expression of protocadherin-1 (PCDH1) during mouse development. Dev Dyn 2008; 237: 2496-2505.
16. GenBank N. www.ncbi.nlm.nih.gov/gene/5097 Date last accessed: September 27, 2013.
17. Bonnelykke K, Pipper CB, Tavendale R, et al. Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth. Pediatr Allergy Immunol 2010; 21: 954-961.
18. Bisgaard H. The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study. Ann Allergy Asthma Immunol 2004; 93: 381-389.
19. Bisgaard H, Pipper CB, Bonnelykke K. Endotyping early childhood asthma by quantitative symptom assessment. J Allergy Clin Immunol 2011; 127: 1155-1164.
20. Halkjaer LB, Loland L, Buchvald FF, et al. Development of atopic dermatitis during the first 3 years of life: The copenhagen prospective study on asthma in childhood cohort study in high-risk children. Arch Dermatol 2006; 142: 561-566.
21. Bisgaard H, Pedersen S, Anhoj J, et al. Determinants of lung function and airway hyperresponsiveness in asthmatic children. Respir Med 2007; 101: 1477-1482.
22. Sleiman PM, Flory J, Imielinski M, et al. Variants of DENND1B associated with asthma in children. N Engl J Med 2010; 362: 36-44.
23. Hakonarson H, Grant SF, Bradfield JP, et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 2007; 448: 591-594.
24. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of ld and haplotype maps. Bioinformatics 2005; 21: 263-265.
25. Broad Institute. Haploview. www.broadinstitute.org/haploview/haploview Date last accessed: September 27, 2013.
26. PLINK. http://pngu.mgh.harvard.edu/purcell/plink/ Date last accessed: September 27, 2013.
27. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
28. HapMap. International HapMap project. http://hapmap.ncbi.nlm.nih.gov/ Date last accessed: September 27, 2013.
29. International HapMap Consortium. The International HapMap Project. Nature 2003; 426: 789-796.
30. R-project development core team. R-project: a language and environment for statistical computing. www.r-project. org/ Date last accessed: September 27, 2013.
31. Abecasis Lab Gds. www.sph.umich.edu/csg/abecasis/MACH/download/1000G- PhaseI-Interim.html Date last accessed: May 6, 2013.
32. Toncheva AA, Suttner K, Michel S, et al. Genetic variants in protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in german children. Pediatr Allergy Immunol 2012; 23: 636-641.
33. Michel S, Liang L, Depner M, et al. Unifying candidate gene and GWAS approaches in asthma. PLoS One 2010; 5: e13894.
34. Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473.