Increased 8-hydroxy-2′-deoxyguanosine in plasma and decreased mRNA expression of human 8-oxoguanine DNA glycosylase 1, anti-oxidant enzymes, mitochondrial biogenesis-related proteins and glycolytic enzymes in leucocytes in patients with systemic lupus erythematosus

Clinical and Experimental Immunology

Volumn 176, Issue 1, 2014, Pages 66-77

  Lee, H T ^a,b,d   Lin, C S ^a,e   Lee, C S ^b,d,f   Tsai, C Y ^a,c   Wei, Y H ^a,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^d MACKAY MEDICAL COLLEGE   (Taiwan)

^e Bali Mental Hospital   (Taiwan)

^f NURSING AND MANAGEMENT COLLEGE   (Taiwan)

Author keywords

8 hydroxy 2 deoxyguanosine (8 OHdG); Anti oxidants; Glycolysis; Mitochondrial biogenesis; Systemic lupus erythematosus (SLE)

Indexed keywords

6 PHOSPHOFRUCTOKINASE; 8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; 8 OXOGUANINE DNA GLYCOSYLASE 1; ADENOSINE TRIPHOSPHATASE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DNA GLYCOSYLTRANSFERASE; GLUCOSE 6 PHOSPHATE ISOMERASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOLYTIC ENZYME; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1; LACTATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MTDNA ENCODED ND 1 POLYPEPTIDE; NUCLEAR RESPIRATORY FACTOR 1; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT; PYRUVATE DEHYDROGENASE KINASE; RITUXIMAB; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE EXPRESSION; GLYCOLYSIS; HETEROPLASMY; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; TREATMENT OUTCOME; YOUNG ADULT;

8-HYDROXY-2′-DEOXYGUANOSINE (8-OHDG); ANTI-OXIDANTS; GLYCOLYSIS; MITOCHONDRIAL BIOGENESIS; SYSTEMIC LUPUS ERYTHEMATOSUS (SLE);

ADULT; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIRHEUMATIC AGENTS; DEOXYGUANOSINE; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE PEROXIDASE; GLYCOLYSIS; HUMANS; LEUKOCYTES; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 84895549107     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12256     Document Type: Article

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