IL6 gene polymorphisms and susceptibility to colorectal cancer: A meta-analysis and review

Molecular Biology Reports

Volumn 39, Issue 8, 2012, Pages 8457-8463

  Yu, Yong ^a   Wang, Wenjun ^b   Zhai, Song ^b   Dang, Shuangsuo ^b   Sun, Mingzhu ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Colorectal cancer; Gene polymorphisms; IL 6; Meta analysis

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; INTERLEUKIN 6;

ALLELE; CANCER DIAGNOSIS; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; DRUG USE; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; IL6 GENE; REVIEW; COLORECTAL TUMOR; DRINKING BEHAVIOR; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ALCOHOL DRINKING; COLORECTAL NEOPLASMS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84868631990     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1699-4     Document Type: Review

References (38)

1. Kishimoto T (2005) Interleukin-6: from basic science to medicine - 40 years in immunology. Annu Rev Immunol 23:1-21
2. Hong DS, Angelo LS, Kurzrock R (2007) Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 110:1911-1928
3. Tsushima H, Ito N, Tamura S, Matsuda Y, Inada M, Yabuuchi I, Imai Y, Nagashima R, Misawa H, Takeda H, Matsuzawa Y, Kawata S (2001) Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer. Clin Cancer Res 7:1258-1262
4. Chung YC, Chaen YL, Hsu CP (2006) Clinical significance of tissue expression of interleukin-6 in colorectal carcinoma. Anticancer Res 26:3905-3911
5. Kim S, Keku TO, Martin C, Galanko J, Woosley JT, Schroeder JC, Satia JA, Halabi S, Sandler RS (2008) Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Res 68:323-328
6. Georges JL, Loukaci V, Poirier O, Evans A, Luc G, Arveiler D, Ruidavets JB, Cambien F, Tiret L (2001) Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-TÊmoin de l'infarctus du Myocarde. J Mol Med 79:300-305
7. Tong Y, Wang Z, Geng Y, Liu J, Zhang R, Lin Q, Li X, Huang D, Gao S, Hu D, Li Y, Cheng J, Lu Z (2010) The association of functional polymorphisms of IL-6 gene promoter with ischemic stroke: analysis in two Chinese populations. Biochem Biophys Res Commun 391:481-485
8. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369-1376
9. Terry CF, Loukaci V, Green FR (2000) Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275:13144-18138
10. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283:2008-2012
11. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719-748
12. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-188
13. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634
14. Gaustadnes M, Orntoft TF, Jensen JL, Torring N (2006) Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. Hum Mutat 27:187-194
15. Chen J, Li D, Chen Z (2007) Investigation of -174G polymorphism of the IL-6 gene promoter in patients with colorectal cancer. Chin J Gen Surg 16:338-340
16. Deng Z, Gong Z, Bostick RM, Gong Y, Berger FG, Xie D (2004) Genetic pollymorphisms in IL6 (-174G/C) and risk for incident sporadic colorectall adenoma. Pro Am Assoc Cancer Res 45:1043
17. Ognjanovic S, Yamamoto J, Saltzman B, Franke A, Ognjanovic M, Yokochi L, Vogt T, Decker R, Le Marchand L (2010) Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population. Cancer Causes Control 21:1131-1138
18. Hawken SJ, Greenwood CM, Hudson TJ, Kustra R, McLaughlin J, Yang Q, Zanke BW, Little J (2010) The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Hum Genet 128:89-101
19. Cacev T, Jokic M, Loncar B, Krizanac S, Kapitanovic S (2010) Interleukin-6 -174 G/C polymorphism is not associated with IL-6 expression and susceptibility to sporadic colon cancer. DNA Cell Bio 29:177-182
20. Vasku A, Vokurka J, Bienertova-Vasku J (2009) Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. Int J Colorectal Dis 24:289-294
21. Tsilidis KK, Helzlsouer KJ, Smith MW, Grinberg V, Hoffman-Bolton J, Clipp SL, Visvanathan K, Platz EA (2009) Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control 20:1739-1751
22. Wilkening S, Tavelin B, Canzian F, Enquist K, Palmqvist R, Altieri A, Hallmans G, Hemminki K, Lenner P, Försti A (2008) Interleukin promoter polymorphisms and prognosis in colorectal cancer. Carcinogenesis 29:1202-1206
23. Küry S, Buecher B, Robiou-du-Pont S, Scoul C, Colman H, Le Neel T, Le Houérou C, Faroux R, Ollivry J, Lafraise B, Chupin LD, Sébille V, Bézieau S (2008) Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. BMC Cancer 8:326
24. Vogel U, Christensen J, Dybdahl M, Friis S, Hansen RD, Wallin H, Nexø BA, Raaschou-Nielsen O, Andersen PS, Overvad K, Tjønneland A (2007) Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. Mutat Res 624:88-100
25. Slattery ML, Wolff RK, Herrick JS, Caan BJ, Potter JD (2007) IL6 genotypes and colon and rectal cancer. Cancer Causes Control 18:1095-1105
26. Theodoropoulos G, Papaconstantinou I, Felekouras E, Nikiteas N, Karakitsos P, Panoussopoulos D, Lazaris ACh, Patsouris E, Bramis J, Gazouli M (2006) Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. World J Gastroenterol 12:5037-5043
27. Keku TO, Galanko J, Omofoye S, Holston R, Peacock J, Barnes J, Martin C, Sandler RS (2006) IL-6, TNF-A and CRP gene polymorphisms are associated with increased colon cancer risk in African Americans compared to whites in the north Carolina colon cancer study. Gastroenterology 130:A54-A55
28. Gunter MJ, Canzian F, Landi S, Chanock SJ, Sinha R, Rothman N (2006) Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomarkers Prev 15:1126-1131
29. Landi S, Moreno V, Gioia-Patricola L, Guino E, Navarro M, de Oca J, Capella G, Canzian F, Bellvitge Colorectal Cancer Study Group (2003) Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor (alpha), NFKB1, and peroxisome proliferator-activated receptor (gamma) with colorectal cancer. Cancer Res 63:3560-3566
30. Chen R, Luo FK, Wang YL, Tang JL, Liu YS (2011) LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese. World J Gastroenterol 17:2326-2331
31. Xu B, Niu XB, Wang ZD, Cheng W, Tong N, Mi YY, Min ZC, Tao J, Li PC, Zhang W, Wu HF, Zhang ZD, Wang ZJ, Hua LX, Feng NH, Wang XR (2011) IL-6 -174G>C polymorphism and cancer risk: a meta-analysis involving 29,377 cases and 37,739 controls. Mol Biol Rep 38:2589-2596
32. Ray A, LaForge KS, Sehgal PB (1990) On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion. Mol Cell Biol 10:5736-5746
33. Chan AT, Ogino S, Giovannucci EL, Fuchs CS (2011) Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs. Gastroenterology 140:799-808
34. Cole BF, Logan RF, Halabi S, Benamouzig R, Sandler RS, Grainge MJ, Chaussade S, Baron JA (2009) Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. J Natl Cancer Inst 101:256-266
35. Din FV, Theodoratou E, Farrington SM, Tenesa A, Barnetson RA, Cetnarskyj R, Stark L, Porteous ME, Campbell H, Dunlop MG (2010) Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut 59:1670-1679
36. Flossmann E, Rothwell PM (2007) Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 369:1603-1613
37. Grau MV, Sandler RS, McKeown-Eyssen G, Bresalier RS, Haile RW, Barry EL, Ahnen DJ, Gui J, Summers RW, Baron JA (2009) Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study. J Natl Cancer Inst 101:267-276
38. Kesarwani P, Ahirwar D, Singh R, Manchanda PK, Mittal RD (2008) Do IL-4 intron 3 VNTR and IL-6 (-174) G/C variants reflect ethnic variation? A comparative study between the global and North Indian populations. Asian Pac J Cancer Prev 9:76-80