The effect of inhibition of endoplasmic reticulum stress on lipolysis in white adipose tissue in a rat model of chronic kidney disease

Acta Pharmacologica Sinica

Volumn 35, Issue 3, 2014, Pages 356-362

  Zhu, Yan ^a,b   Chen, Yu Ling ^a,b   Li, Cong ^a,b   Ding, Xiao Yan ^a,b   Xu, Guo Yu ^a,b   Hu, Li Li ^a,b   Hou, Fan Fan ^a,b   Zhou, Qiu Gen ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

chronic kidney disease; ER stress; lipolysis; white adipose tissue

Indexed keywords

COMPARATIVE GENE IDENTIFICATION 58 PROTEIN; GLUCOSE REGULATED PROTEIN 78; GLYCEROL; HORMONE SENSITIVE LIPASE; INITIATION FACTOR 2ALPHA; PROTEIN; PROTEIN IRE1; PROTEIN IRE1 ALPHA; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; 4-PHENYLBUTYRIC ACID; ABHD5 PROTEIN, RAT; ACYLTRANSFERASE; ARYLBUTYRIC ACID DERIVATIVE; CHOLESTEROL ESTERASE; ERN2 PROTEIN, RAT; INITIATION FACTOR 2; MEMBRANE PROTEIN; PERK KINASE; PNPLA2 PROTEIN, RAT; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; EX VIVO STUDY; IMMUNOPRECIPITATION; INTRAABDOMINAL FAT; LIPOLYSIS; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; ANIMAL; CELL CULTURE; CHRONIC KIDNEY FAILURE; DISEASE MODEL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ACYLTRANSFERASES; ADIPOCYTES; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; GLYCEROL; INTRA-ABDOMINAL FAT; LIPASE; LIPOLYSIS; MALE; MEMBRANE PROTEINS; PHENYLBUTYRATES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; STEROL ESTERASE;

EID: 84895531939     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.177     Document Type: Article

References (33)

1. Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 2008; 73: 391-8.
2. Keane WF, Tomassini JE, Neff DR. Lipid abnormalities in patients with chronic kidney disease. Contrib Nephrol 2011; 171: 135-42.
3. Ruan XZ, Moorhead JF, Varghese Z. Lipid redistribution in renal dysfunction. Kidney Int 2008; 74: 407-9.
4. Aminzadeh MA, Pahl MV, Barton CH, Doctor NS, Vaziri ND. Human uraemic plasma stimulates release of leptin and uptake of tumour necrosis factor-alpha in visceral adipocytes. Nephrol Dial Transplant 2009; 24: 3626-31.
5. Axelsson J, Astrom G, Sjolin E, Qureshi AR, Lorente-Cebrian S, Stenvinkel P, et al. Uraemic sera stimulate lipolysis in human adipocytes: role of perilipin. Nephrol Dial Transplant 2011; 26: 2485-91.
6. Kalbacher E, Koppe L, Zarrouki B, Pillon NJ, Fouque D, Soulage CO. Human uremic plasma and not urea induces exuberant secretion of leptin in 3T3-L1 adipocytes. J Ren Nutr 2011; 21: 72-5.
7. Wang S, Soni KG, Semache M, Casavant S, Fortier M, Pan L, et al. Lipolysis and the integrated physiology of lipid energy metabolism. Mol Genet Metab 2008; 95: 117-26.
8. Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, et al. Metabolite profiling identifies markers of uremia. J Am Soc Nephrol 2010; 21: 1041-51.
9. Zhou QG, Zhou M, Hou FF, Peng X. Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes. Am J Physiol Endocrinol Metab 2009; 296: E869-78.
10. Kalantar-Zadeh K, Kuwae N, Wu DY, Shantouf RS, Fouque D, Anker SD, et al. Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am J Clin Nutr 2006; 83: 202-10.
11. Basseri S, Austin RC. Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. Biochem Res Int 2012; 2012: 841362.
12. Gregor MF, Hotamisligil GS. Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 2007; 48: 1905-14.
13. Boden G, Duan X, Homko C, Molina EJ, Song W, Perez O, et al. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 2008; 57: 2438-44.
14. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306: 457-61.
15. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-6.
16. Deng J, Liu S, Zou L, Xu C, Geng B, Xu G. Lipolysis response to endoplasmic reticulum stress in adipose cells. J Biol Chem 2012; 287: 6240-9.
17. Cybulsky AV. Endoplasmic reticulum stress in proteinuric kidney disease. Kidney Int 2010; 77: 187-93.
18. Zhou QG, Fu XJ, Xu GY, Cao W, Liu HF, Nie J, et al. Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. Am J Physiol Heart Circ Physiol 2012; 303: H1154-65.
19. Huang ZH, Reardon CA, Mazzone T. Endogenous ApoE expression modulates adipocyte triglyceride content and turnover. Diabetes 2006; 55: 3394-402.
20. Gaidhu MP, Anthony NM, Patel P, Hawke TJ, Ceddia RB. Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK. Am J Physiol Cell Physiol 2010; 298: C961-71.
21. Lass A, Zimmermann R, Oberer M, Zechner R. Lipolysis-a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res 2011; 50: 14-27.
22. Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res 2009; 50: 3-21.
23. Ryden M, Jocken J, van Harmelen V, Dicker A, Hoffstedt J, Wiren M, et al. Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis. Am J Physiol Endocrinol Metab 2007; 292: E1847-55.
24. Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 2006; 3: 309-19.
25. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006; 313: 1137-40.
26. Zechner R, Zimmermann R, Eichmann TO, Kohlwein SD, Haemmerle G, Lass A, et al. FAT SIGNALS-lipases and lipolysis in lipid metabolism and signaling. Cell Metab 2012; 15: 279-91.
27. Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 2011; 478: 110-3.
28. Frayn K, Bernard S, Spalding K, Arner P. Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia. J Am Heart Assoc 2012; 1: e003467.
29. Roubicek T, Bartlova M, Krajickova J, Haluzikova D, Mraz M, Lacinova Z, et al. Increased production of proinflammatory cytokines in adipose tissue of patients with end-stage renal disease. Nutrition 2009; 25: 762-8.
30. Pelletier CC, Koppe L, Croze ML, Kalbacher E, Vella RE, Guebre-Egziabher F, et al. White adipose tissue overproduces the lipid-mobilizing factor zinc alpha2-glycoprotein in chronic kidney disease. Kidney Int 2013; 83: 878-86.
31. Lafontan M, Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res 2009; 48: 275-97.
32. Granneman JG, Moore HP, Granneman RL, Greenberg AS, Obin MS, Zhu Z. Analysis of lipolytic protein trafficking and interactions in adipocytes. J Biol Chem 2007; 282: 5726-35.
33. Zhou QG, Zhou M, Lou AJ, Xie D, Hou FF. Advanced oxidation protein products induce inflammatory response and insulin resistance in cultured adipocytes via induction of endoplasmic reticulum stress. Cell Physiol Biochem 2010; 26: 775-86.