The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 4, 2014, Pages 537-545

  Popovic, Matija ^a   Wienk, Hans ^b   Coglievina, Maristella ^a   Boelens, Rolf ^b   Pongor, Sándor ^a   Pintar, Alessandro ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Backbone dynamics; Chemical shift perturbation; Conformational selection; NMR; Secondary structure

Indexed keywords

HELIX LOOP HELIX PROTEIN; PROLINE; TRANSCRIPTION FACTOR HES 1;

ARTICLE; BINDING SITE; DNA BINDING; DROSOPHILA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

BACKBONE DYNAMICS; CHEMICAL SHIFT PERTURBATION; CONFORMATIONAL SELECTION; NMR; SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; DNA-BINDING PROTEINS; HELIX-LOOP-HELIX MOTIFS; HOMEODOMAIN PROTEINS; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84895529675     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24507     Document Type: Article

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