Critical evaluation of lowering the recommended dietary intake of folate

Clinical Nutrition

Volumn 33, Issue 2, 2014, Pages 252-259

  Obeid, Rima ^a   Koletzko, Berthold ^b   Pietrzik, Klaus ^c  

^a SAARLAND UNIVERSITY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Folate intake; Pregnancy; Requirements

Indexed keywords

BIOLOGICAL MARKER; FOLIC ACID; HOMOCYSTEINE; METHYLFOLIC ACID; UNCLASSIFIED DRUG;

AGE; ANEMIA; ARTICLE; BIRTH DEFECT; CONCEPTION; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE ASSOCIATION; DOSE RESPONSE; FOLIC ACID BLOOD LEVEL; GENETIC POLYMORPHISM; HUMAN; LIFESTYLE; NEURAL TUBE DEFECT; OBESITY; PREGNANCY; PREPREGNANCY; PROTEIN BLOOD LEVEL; RISK REDUCTION; SMOKING;

FOLATE INTAKE; PREGNANCY; REQUIREMENTS;

ANEMIA; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLIC ACID; GENETIC MARKERS; HOMOCYSTEINE; HUMANS; LIFE STYLE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NEURAL TUBE DEFECTS; POLYMORPHISM, GENETIC; PREGNANCY; PREGNANCY COMPLICATIONS; RECOMMENDED DIETARY ALLOWANCES; TREATMENT OUTCOME;

EID: 84895491147     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.12.013     Document Type: Article

References (30)

1. Institute of Medicine Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline 1998, 390-422. National Academy Press, USA, Washington, DC.
2. Herbert V. Minimal daily adult folate requirement. Arch Intern Med 1962, 110:649-652.
3. O'Keefe C.A., Bailey L.B., Thomas E.A., Hofler S.A., Davis B.A., Cerda J.J., et al. Controlled dietary folate affects folate status in nonpregnant women. J Nutr 1995, 125:2717-2725.
4. Deutsche Gesellschaft für Ernährung e.V. 12. Ernährungsbericht 2012, 40-85.
5. Sauberlich H.E., Kretsch M.J., Skala J.H., Johnson H.L., Taylor P.C. Folate requirement and metabolism in nonpregnant women. Am J Clin Nutr 1987, 46:1016-1028.
6. Milne D.B., Johnson L.K., Mahalko J.R., Sandstead H.H. Folate status of adult males living in a metabolic unit: possible relationships with iron nutriture. Am J Clin Nutr 1983, 37:768-773.
7. Deutsche Gesellschaft für Ernährung e.V. 12. Ernährungsbericht 2012, 86-97.
8. Berry R.J., Li Z., Erickson J.D., Li S., Moore C.A., Wang H., et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999, 341:1485-1490.
9. Daly L.E., Kirke P.N., Molloy A., Weir D.G., Scott J.M. Folate levels and neural tube defects. Implications for prevention. J Am Med Assoc 1995, 274:1698-1702.
10. Moore L.L., Bradlee M.L., Singer M.R., Rothman K.J., Milunsky A. Folate intake and the risk of neural tube defects: an estimation of dose-response. Epidemiology 2003, 14:200-205.
11. Kirke P.N., Molloy A.M., Daly L.E., Burke H., Weir D.G., Scott J.M. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993, 86:703-708.
12. Lewis S.J., Leary S., Davey S.G., Ness A. Body composition at age 9 years, maternal folate intake during pregnancy and methyltetrahydrofolate reductase (MTHFR) C677T genotype. Br J Nutr 2009, 102:493-496.
13. Shelnutt K.P., Kauwell G.P., Chapman C.M., Gregory J.F., Maneval D.R., Browdy A.A., et al. Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C→T polymorphism in young women. J Nutr 2003, 133:4107-4111.
14. Crider K.S., Zhu J.H., Hao L., Yang Q.H., Yang T.P., Gindler J., et al. MTHFR 677C→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Am J Clin Nutr 2011, 93:1365-1372.
15. Tseng Y.L., Chang Y.Y., Liu J.S., Su C.S., Lai S.L., Lan M.Y. Association of plasma homocysteine concentration with cerebral white matter hyperintensity on magnetic resonance images in stroke patients. J Neurol Sci 2009, 284:36-39.
16. Rost N.S., Rahman R., Sonni S., Kanakis A., Butler C., Massasa E., et al. Determinants of white matter hyperintensity volume in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis 2010, 19:230-235.
17. Wald N.J., Law M.R., Morris J.K., Wald D.S. Quantifying the effect of folic acid. Lancet 2001, 358:2069-2073.
18. Hao L., Yang Q.H., Li Z., Bailey L.B., Zhu J.H., Hu D.J., et al. Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial. Am J Clin Nutr 2008, 88:448-457.
19. Pietrzik K., Lamers Y., Bramswig S., Prinz-Langenohl R. Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age. Am J Clin Nutr 2007, 86:1414-1419.
20. Berti C., Fekete K., Dullemeijer C., Trovato M., Souverein O.W., Cavelaars A., et al. Folate intake and markers of folate status in women of reproductive age, pregnant and lactating women: a meta-analysis. J Nutr Metab 2012, 2012:470656.
21. Steenweg-de Graaff J., Roza S.J., Steegers E.A., Hofman A., Verhulst F.C., Jaddoe V.W., et al. Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study. Am J Clin Nutr 2012, 95:1413-1421.
22. Obeid R., Kasoha M., Kirsch S.H., Munz W., Herrmann W. Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood. Am J Clin Nutr 2010, 92:1416-1422.
23. Brown J.E., Jacobs D.R., Hartman T.J., Barosso G.M., Stang J.S., Gross M.D., et al. Predictors of red cell folate level in women attempting pregnancy. J Am Med Assoc 1997, 277:548-552.
24. Truthmann J., Richter A., Thiele S., Drescher L., Roosen J., Mensink G.B. Associations of dietary indices with biomarkers of dietary exposure and cardiovascular status among adolescents in Germany. Nutr Metab (Lond) 2012, 9:92.
25. de Bree A., Verschuren W.M., Blom H.J., Kromhout D. Association between B vitamin intake and plasma homocysteine concentration in the general Dutch population aged 20-65 y. Am J Clin Nutr 2001, 73:1027-1033.
26. Kirsch S.H., Herrmann W., Eckert R., Geisel J., Obeid R. Factors affecting the distribution of folate forms in the serum of elderly German adults. Eur J Nutr 2013, 52:497-504.
27. Rydlewicz A., Simpson J.A., Taylor R.J., Bond C.M., Golden M.H. The effect of folic acid supplementation on plasma homocysteine in an elderly population. QJM 2002, 95(1):27-35.
28. van Oort F.V., Melse-Boonstra A., Brouwer I.A., Clarke R., West C.E., Katan M.B., et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. Am J Clin Nutr 2003, 77:1318-1323.
29. Molloy A.M., Daly S., Mills J.L., Kirke P.N., Whitehead A.S., Ramsbottom D., et al. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 1997, 349:1591-1593.
30. Ashfield-Watt P.A., Pullin C.H., Whiting J.M., et al. Methylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial. Am J Clin Nutr 2002, 76:180-186.