Multi-stage continuous high cell density culture systems: A review

Biotechnology Advances

Volumn 32, Issue 2, 2014, Pages 514-525

  Chang, Ho Nam ^a   Jung, Kwonsu ^a   Choi, Jin dal rae ^a,d   Lee, Joon Chul ^b   Woo, Hee Chul ^c  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Institute of Industrial Technology   (South Korea)

^c Pukyong National University   (South Korea)

^d GS Caltex Corporation   (South Korea)

Author keywords

High cell density culture; Multi stage continuous bioreactors; Product titer improvement; Productivity improvement

Indexed keywords

BIOREACTORS; CELLS; CYTOLOGY; ENZYME ACTIVITY; MONOCLONAL ANTIBODIES; PRODUCTIVITY; VOLATILE FATTY ACIDS;

CONTINUOUS BIOREACTORS; HIGH CELL DENSITY CULTURES; HIGH-DENSITY CULTURES; HYDRAULIC RETENTION TIME; INTRACELLULAR PRODUCTS; POLYHYDROXYBUTYRIC ACID; PRODUCT TITER IMPROVEMENT; PRODUCTIVITY IMPROVEMENTS;

CONTINUOUS CELL CULTURE;

ANTIBODY; BIOREACTOR; CELL ORGANELLE; HYDRAULIC CONDUCTIVITY; INDUSTRIALIZATION; LITERATURE REVIEW; REACTION KINETICS; VOLATILE SUBSTANCE; YEAST;

ANIMALIA; BACTERIA (MICROORGANISMS);

BIOFUEL; RECOMBINANT PROTEIN;

BACTERIUM; BIOREACTOR; CELL COUNT; CULTURE MEDIUM; CULTURE TECHNIQUE; EQUIPMENT; FERMENTATION; HIGH CELL DENSITY CULTURE; METABOLISM; METHODOLOGY; MULTI-STAGE CONTINUOUS BIOREACTORS; PRODUCT TITER IMPROVEMENT; PRODUCTIVITY IMPROVEMENT; REVIEW;

HIGH CELL DENSITY CULTURE; MULTI-STAGE CONTINUOUS BIOREACTORS; PRODUCT TITER IMPROVEMENT; PRODUCTIVITY IMPROVEMENT;

BACTERIA; BIOFUELS; BIOREACTORS; CELL COUNT; CELL CULTURE TECHNIQUES; CULTURE MEDIA; FERMENTATION; RECOMBINANT PROTEINS;

EID: 84895486224     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2014.01.004     Document Type: Review

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