Possible direct influence of complement 3 in decreasing insulin sensitvity in a cohort of overweight and obese subjects

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 13, Issue 4, 2013, Pages 301-305

  De Pergola, Giovanni ^a   Tartagni, Massimo ^a   Bartolomeo, Nicola ^a   Bruno, Irene ^a   Masiello, Michele ^a   Caccavo, Domenico ^a   Bavaro, Serena ^a   Silvestris, Franco ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

Author keywords

Body fat distribution; Complement 3; Gender; Inflammation; Insulin; Obesity; Physical activity

Indexed keywords

COMPLEMENT COMPONENT C3; GLUCOSE; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; BODY MASS; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; GENDER; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; OBESITY; PHYSICAL ACTIVITY; QUESTIONNAIRE; SITTING; WAIST CIRCUMFERENCE; ADOLESCENT; BLOOD; METABOLISM; MIDDLE AGED; OVERWEIGHT; PHYSIOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; BODY MASS INDEX; COHORT STUDIES; COMPLEMENT C3; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; YOUNG ADULT;

EID: 84895457217     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/1871530314666140116111542     Document Type: Article

References (13)

1. Yang, K.; De Angelis, R.A.; Reed, J.E.; Ricklin, D. and Lambris, J.D. (2013) Complement in action: an analysis of patent from 1976 through 2011. Adv. Exp. Med. Biol., 734a, 301-313.
2. Galassetti, P. (2012) Inflammation and oxidative stress in obesity, metabolic syndrome, and diabetes. Exp. Diabetes Res., 2012, 943706.
3. Blogowski, W.; Budkowska, M.; Salata, D.; Serwin, K.; Dolegowska, B.; Lokaj, M.; Prowans, P. and Starzynska, T. (2013) Clinical analysis of selected complement-derived molecules in human adipose tissue. J. Transl. Med., 11, 11.
4. De Pergola, G.; Ciccone, M.; Guida, P.; Morea, G.; Giannuzzo, E.; Cortese, F.; Scicchitano, P.; Favale, S. and Silvestris, F. (2011) Relationship between C3 levels and common carotid intima-media thickness in overweight and obese patients. Obes. Facts, 4, 159-163.
5. Gabrielsson, B.G.; Johansson, J.M.; Lonn, M.; Jernås, M.; Olbers, T.; Peltonen, M.; Larsson, I.; Lönn, L.; Sjöström, L.; Carlsson, B. and Carlsson, L.M. (2003) High expression of complement components in omental adipose tissue in obese men. Obes. Res., 11, 699-708.
6. Koistinen, H.A.; Vidal, H.; Karonen, S.L.; Dusserre, E.; Vallier, P.; Koivisto, V.A. and Ebeling, P. (2001) Plasma acylation stimulating protein concentration and subcutaneous adipose tissue C3 mRNA expression in nondiabetic and type 2 diabetic men. Arterioscler. Thromb. Vasc. Biol., 21, 1034-1039.
7. Somani, R.; Richardson, V.R.; Standeven, K.F.; Grant, P.J. and Carter, A.M. (2012) Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes. Diabetes Care, 35, 894-899.
8. Engström, G.; Hedblad, B.; Eriksson, K.F.; Janzon, L. and Lindgärde, F. (2005) Complement C3 is a risk factor for the development of diabetes: a population-based cohort study. Diabetes, 54, 570-575.
9. Raynor, L.A.; Pankow, J.S.; Duncan, B.B.; Schmidt, M.I.; Hoogeveen, R.C.; Pereira, M.A.; Young, J.H. and Ballantyne, C.M. (2013) Novel risk factors and the prediction of type 2 diabetes in the Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care, 36, 70-76
10. Muscari, A.; Antonelli, S.; Bianchi, G.; Cavrini, G.; Dapporto, S.; Ligabue, A.; Ludovico, C.; Magalotti, D.; Poggiopollini, G. and Zoli, M. (2007) Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate. Diabetes Care, 30, 2362-2368.
11. Bonora, E.; Targher, G.; Alberiche, M.; Bonadonna, R.C.; Saggiani, F.; Zenere, M.B.; Monauni, T. and Muggeo, M. (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care, 23, 57-63.
12. Mamane, Y.; Chan, C.C.; Lavalle, G.; Morin, N.; Xu, L.J.; Huang, J.; Gordon, R.; Thomas, W.; Lamb, J.; Schadt, E.E.; Kennedy, B.P. and Mancini, J.A. (2009) The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes, 58, 2006-2017.
13. Wu, G.; Hu, W.; Shahsafaei, A.; Song, W.; Dobarro, M.; Sukhova, G.K.; Bronson, R.R.; Shi, G.P.; Rother, R.P.; Halperin, J.A. and Qin, X. (2009) Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ. Res., 104, 550-558.