Complement regulator cd59 protects against atherosclerosis by restricting the formation of complement membrane attack complex

Circulation Research

Volumn 104, Issue 4, 2009, Pages 550-558

  Wu, Gongxiong ^a,b,c   Hu, Weiguo ^a,b   Shahsafaei, Aliakbar ^a   Song, Wenping ^a   Dobarro, Martin ^a   Sukhova, Galina K ^a   Bronson, Rod R ^b   Shi, Guo Ping ^a   Rother, Russell P ^d   Halperin, Jose A ^a,b   Qin, Xuebin ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

^d Alexion Pharmaceuticals Inc   (United States)

Author keywords

Atherosclerosis; CD59; Complement; Endothelial dysfunction; Occlusive coronary atherosclerosis and vulnerable plaque

Indexed keywords

CD59 ANTIGEN; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT RECEPTOR; APOLIPOPROTEIN E; CD59 PROTEIN, HUMAN; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATTENUATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; ENDOTHELIUM; HUMAN; HUMAN CELL; HYPERLIPOPROTEINEMIA TYPE 3; ISCHEMIC HEART DISEASE; MEMBRANE FORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; C57BL MOUSE; CELL LINE; COMPLEMENT ACTIVATION; CORONARY ARTERY DISEASE; DISEASE COURSE; DISEASE MODEL; FAT INTAKE; FOAM CELL; GENETICS; HOSPITALIZATION; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHENOTYPE; RABBIT; TIME; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD59; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL LINE; COMPLEMENT ACTIVATION; COMPLEMENT C5; COMPLEMENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; CORONARY ARTERY DISEASE; DIETARY FATS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; FOAM CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; RABBITS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 61949366191     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.191361     Document Type: Article

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