Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Long, Zaiyang ^a,b   Li, Xiang Rong ^c   Xu, Jun ^a,b   Edden, Richard A E ^d,e   Qin, Wei Ping ^f   Long, Li Ling ^c   Murdoch, James B ^g   Zheng, Wei ^a   Jiang, Yue Ming ^c   Dydak, Ulrike ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GUANGXI MEDICAL UNIVERSITY   (China)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e KENNEDY KRIEGER INSTITUTE   (United States)

^f Guangxi Cancer Prevention and Treatment Institute   (China)

^g Toshiba Medical Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; INOSITOL; MANGANESE; N ACETYLASPARTIC ACID;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ADULT; ARTICLE; CONTROLLED STUDY; FINE MOTOR PERFORMANCE; HUMAN; IRON AND STEEL INDUSTRY; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCUPATIONAL EXPOSURE; POSTERIOR CINGULATE; SMELTER; THALAMUS;

ADULT; GAMMA-AMINOBUTYRIC ACID; HUMANS; IRON; MALE; MANGANESE; MOTOR ACTIVITY; NEUROLOGIC EXAMINATION; OCCUPATIONAL EXPOSURE; THALAMUS;

EID: 84895445572     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088220     Document Type: Article

References (46)

1. Aschner JL, Aschner M (2005) Nutritional aspects of manganese homeostasis. Mol Aspects Med 26(4-5):353-362. (Pubitemid 41225358)
2. Crossgrove J, Zheng W (2004) Manganese toxicity upon overexposure. NMR Biomed 17(8):544-553. (Pubitemid 40124780)
3. Racette BA, McGee-Minnich L, Moerlein SM, Mink JW, Videen TO, et al. (2001) Welding-related parkinsonism: clinical features, treatment, and pathophysiology. Neurology 56(1):8-13.
4. Guilarte TR (2010) Manganese and Parkinson's disease: a critical review and new findings. Environ Health Perspect 118(8):1071-1080.
5. Kim SH, Chang KH, Chi JG, CheongHK, Kim JY, et al. (1999) Sequential change of MR signal intensity of the brain after manganese administration in rabbits. Correlation with manganese concentration and histopathologic findings. Invest Radiol 34(6):383-393. (Pubitemid 29239354)
6. Lucchini R, Albini E, Placidi D, Gasparotti R, Pigozzi MG, et al. (2000) Brain magnetic resonance imaging and manganese exposure. Neurotoxicology 21(5):769-775.
7. Jiang Y, Zheng W, Long L, Zhao W, Li X, et al. (2007) Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: search for biomarkers of manganese exposure. Neurotoxicology 28(1):126-135. (Pubitemid 46187265)
8. Sen S, Flynn MR, Du G, Troster AL, An H, et al. (2011) Manganese accumulation in the olfactory bulbs and other brain regions of "asymptomatic" welders. Toxicol Sci 121(1):160-17.
9. Guilarte TR, McGlothan JL, Degaonkar M, Chen MK, Barker PB, et al. (2006) Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study. Toxicol Sci 94(2):351-358. (Pubitemid 44817151)
10. Dydak U, Jiang YM, Long LL, Zhu H, Chen J, et al. (2011) In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Environ Health Perspect 119(2):219-224.
11. Chang Y, Woo ST, Lee JJ, Song HJ, Lee HJ, et al. (2009) Neurochemical changes in welders revealed by proton magnetic resonance spectroscopy. Neurotoxicology 30(6):950-957.
12. Chang Y, Kim Y, Woo ST, Song HJ, Kim SH, et al. (2009) High signal intensity on magnetic resonance imaging is a better predictor of neurobehavioral performances than blood manganese in asymptomatic welders. Neurotoxicology 30(4):555-563.
13. Groenewegen HJ (2003) The basal ganglia and motor control. Neural Plast 10(1-2): 107-120.
14. Hikosaka O (2007) GABAergic output of the basal ganglia. Prog Brain Res 160: 209-226.
15. Galvan A, Wichmann T (2007) GABAergic circuits in the basal ganglia and movement disorders. Prog Brain Res 160:287-312. (Pubitemid 46702298)
16. Galeffi F, Bianchi L, Bolam JP, Della Corte L (2003) The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis. Eur J Neurosci 18(4):856-868. (Pubitemid 37059695)
17. Soares J, Kliem MA, Betarbet R, Greenamyre JT, Yamamoto B et al. (2004) Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segment. J Neurosci 24(29):6417-6426. (Pubitemid 38971688)
18. Kish S, Rajput A, Gilbert J, Rozdilsky B, Chang LJ, et al. (1987) GABA-dopamine relationship in Parkinson's disease striatum. Adv Neurol 45:75-77.
19. Hornykiewicz O (2001) Chemical neuroanatomy of the basal ganglia-normal and in Parkinson's disease. J Chem Neuroanat 22:3-12.
20. Emir UE, Tuite PJ, Oz G (2012) Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 tesla proton MRS. PLoS One 7(1):e30918.
21. Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R (1998) Simultaneous in vivo spectral editing and water suppression. NMR Biomed 11(6):266-272. (Pubitemid 28465190)
22. Edden RA, Barker PB (2007) Spatial effects in the detection of gamma-aminobutyric acid: improved sensitivity at high fields using inner volume saturation. Magn Reson Med 58(6):1276-1282. (Pubitemid 350234215)
23. Provencher SW (1993) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30(6):672-679.
24. Govindaraju V, Young K, Maudsley AA (2000) Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 13(3):129-153. (Pubitemid 30414704)
25. Cowan DM, Zheng W, Zou Y, Shi X, Chen J, et al. (2009) Manganese exposure among smelting workers: relationship between blood manganese-iron ratio and early onset neurobehavioral alterations. Neurotoxicology 30(6):1214-1222.
26. Geurts JJ, Barkhof F, Castelijns JA, Uitdehaag BM, Polman CH, et al. (2004) Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: metabolite concentrations, quantification precision, and reproducibility. J Magn Reson Imaging 20(3):366-371. (Pubitemid 39121932)
27. Bonilla E, Arrieta A, Castro F, Davila JO, Quiroz I (1994) Manganese toxicity: free amino acids in the striatum and olfactory bulb of the mouse. Invest Clin 35(4):175-181.
28. Brouillet EP, Shinobu L, Mcgarvey U, Hochberg F, Beal MF (1993) Manganese Injection into the Rat Striatum Produces Excitotoxic Lesions by Impairing Energy-Metabolism. Experimental Neurology 120(1):89-94. (Pubitemid 23114032)
29. Seth PK, Hong JS, Kilts CD, Bondy SC (1981) Alteration of cerebral neurotransmitter receptor function by exposure of rats to manganese. Toxicol Lett 9(3):247-254. (Pubitemid 12203957)
30. Bonilla E (1978) Increased GABA content in caudate nucleus of rats after chronic manganese chloride administration. J Neurochem 31(2):551-552.
31. Lipe GW, Duhart H, Newport GD, Slikker W Jr, Ali SF (1999) Effect of manganese on the concentration of amino acids in different regions of the rat brain. J Environ Sci Health B 34(1):119-132. (Pubitemid 29093624)
32. Gwiazda RH, Lee D, Sheridan J, Smith DR (2002) Low cumulative manganese exposure affects striatal GABA but not dopamine. Neurotoxicology 23(1):69-76. (Pubitemid 36559699)
33. Fordahl SC, Anderson JG, Cooney PT, Weaver TL, Colyer CL, et al. (2010) Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats. Neurotoxicology 31(6):639-646.
34. Guilarte TR, Chen MK, McGlothan JL, Verina T, Wong DF, et al. (2006) Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Exp. Neurol. 202:381-390. (Pubitemid 44692681)
35. Guilarte TR, Burton NC, McGlothan JL, Verina T, Zhou Y, et al. (2008) Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism. J. Neurochem. 107:1236-1247.
36. 18F]FDOPA PET in asymptomatic welders with occupational manganese exposure. Neurology 76:1296-1301.
37. Kurata K (2005) Activity properties and location of neurons in the motor thalamus that project to the cortical motor areas in monkeys. J Neurophysiol 94(1):550-566.
38. Bhattacharyya PK, Philips MD, Stone LA, Bermel RA, Lowe MJ. (2013) Sensorimotor cortex gamma-aminobutyric acid concentration correlates with impaired performance in patients with MS. AJNR Am J Neuroradiol. 34(9):1733-1739.
39. Bowler RM, Roels HA, Nakagawa S, Drezgic M, Diamond E, et al. (2007) Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders. Occup Environ Med 64(3):167-177. (Pubitemid 46579825)
40. Park RM, Bowler RM, Roels HA (2009) Exposure-response relationship and risk assessment for cognitive deficits in early welding-induced manganism. J Occup Environ Med 51(10):1125-1136.
41. Bowler RM, Gysens S, Diamond E, Nakagawa S, Drezgic M, et al. (2006) Manganese exposure: neuropsychological and neurological symptoms and effects in welders. Neurotoxicology 27(3): 315-326.
42. Wastensson G, Sallsten G, Bast-Pettersen R, Barregard L (2012) Neuromotor function in ship welders after cessation of manganese exposure. Int Arch Occup Envion Health. 85(6):703-713.
43. Mergler D, Huel G, Bowler R, Iregren A, Belanger S, et al. (1994) Nervous system dysfunction among workers with long-term exposure to manganese. Environ Res. 64(2):151-180. (Pubitemid 24068378)
44. nd ed) New York: Oxford Univer. Press.
45. Brand A, Richter-Landsberg C, Leibfritz D (1993) Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15(3-5):289-298. (Pubitemid 24258162)
46. Zhao F, Cai T, Liu M, Zheng G, Luo W, et al. (2009) Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism. Toxicol Sci 107(1):156-164.