Fentanyl: Cause of death or incidental finding? Postmortem peripheral blood concentrations with and without documented transdermal patch use

Forensic Toxicology

Volumn 32, Issue 1, 2014, Pages 118-125

  Lung, Derrick D ^a,b   Lemos, Nikolas P ^b,c  

^a California Poison Control System   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Office of the Chief Medical Examiner   (United States)

Author keywords

Cause of death; Fentanyl; Peripheral blood; Postmortem forensic toxicology; Transdermal patch

Indexed keywords

EID: 84895191496     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-013-0216-3     Document Type: Article

References (26)

1. Jones AW, Holmgren A, Ahlner J (2012) Heroin poisoning deaths with 6-acetylmorphine in blood: demographics of the victims, previous drug-related offences, polydrug use, and free morphine concentrations in femoral blood. Forensic Toxicol 30:19-24
2. Deventer K, Pozo OJ, Delbeke FT, Van Eenoo P (2012) Direct quantification of morphine glucuronides and free morphine in urine by liquid chromatography-tandem mass spectrometry. Forensic Toxicol 30:106-113
3. 9-tetrahydrocannabinol-9-carboxylic acid from a limited volume of urine using a monolithic silica spin column coupled with gas chromatography-mass spectrometry. Forensic Toxicol 31:312-321
4. National Association of Medical Examiners (2013) Position paper: recommendations for the investigation, diagnosis and certification of deaths related to opioid drugs. Acad Forensic Pathol 3:77-83
5. Hug CCJ, Murphy MR (1981) Tissue redistribution of fentanyl and termination of its effects in rats. Anesthesiology 55:369-375
6. Thompson JG, Baker AM, Bracey AH, Seningen J, Kloss JS, Strobl AQ, Apple FS (2007) Fentanyl concentrations in 23 postmortem cases from the Hennepin county medical examiner's office. J Forensic Sci 52:978-981
7. ®): seven case reports. J Forensic Sci 53:222-225
8. Olson KN, Luckenbill K, Thompson J, Middleton O, Geiselhart R, Mills KM, Kloss J, Apple FS (2010) Postmortem redistribution of fentanyl in blood. Am J Clin Pathol 133:447-453
9. Anderson DT, Muto JJ (2000) Duragesic transdermal patch: postmortem tissue distribution of fentanyl in 25 cases. J Anal Toxicol 24:627-634
10. Luckenbill K, Thompson J, Middleton O, Kloss J, Apple F (2008) Fentanyl postmortem redistribution: preliminary findings regarding the relationship among femoral blood and liver and heart tissue concentrations. J Anal Toxicol 32:639-643
11. Martin TL, Woodall KL, McLellan BA (2006) Fentanyl-related deaths in Ontario, Canada: toxicological findings and circumstances of death in 112 cases (2002-2004). J Anal Toxicol 30:603-610
12. Marquardt KA, Tharratt RS (1994) Inhalation abuse of fentanyl patch. J Toxicol Clin Toxicol 32:75-78
13. Gill JR, Lin PT, Nelson L (2013) Reliability of postmortem fentanyl concentrations in determining the cause of death. J Med Toxicol 9:34-41
14. Henderson GL (1991) Fentanyl-related deaths: demographics, circumstances, and toxicology of 112 cases. J Forensic Sci 36:422-433
15. Kuhlman JJ Jr, McCaulley R, Valouch TJ, Behonick GS (2003) Fentanyl use, misuse, and abuse: a summary of 23 postmortem cases. J Anal Toxicol 27:499-504
16. Denton JS, Donoghue ER, McReynolds J, Kalelkar MB (2008) An epidemic of illicit fentanyl deaths in Cook County, Illinois: September 2005 through April 2007. J Forensic Sci 53:452-454
17. Palamalai V, Olson KN, Kloss J, Middleton O, Mills K, Strobl AQ, Thomas LC, Apple FS (2013) Superiority of postmortem liver fentanyl concentrations over peripheral blood influenced by postmortem interval for determination of fentanyl toxicity. Clin Biochem 46:598-602
18. Biedrzycki OJ, Bevan D, Lucas S (2009) Fatal overdose due to prescription fentanyl patches in a patient with sickle cell/beta-thalassemia and acute chest syndrome: a case report and review of the literature. Am J Forensic Med Pathol 30:188-190
19. Coopman V, Cordonnier J, Pien K, Van Varenbergh D (2007) LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple duragesic transdermal therapeutic systems. Forensic Sci Int 169:223-227
20. Jumbelic MI (2010) Deaths with transdermal fentanyl patches. Am J Forensic Med Pathol 31:18-21
21. Lilleng PK, Mehlum LI, Bachs L, Morild I (2004) Deaths after intravenous misuse of transdermal fentanyl. J Forensic Sci 49:1364-1366
22. Tharp AM, Winecker RE, Winston DC (2004) Fatal intravenous fentanyl abuse: four cases involving extraction of fentanyl from transdermal patches. Am J Forensic Med Pathol 25:178-181
23. Wiesbrock UO, Rochholz G, Franzelius C, Schwark T, Grellner W (2008) Excessive use of fentanyl patches as the only means of suicide. Arch Kriminol 222:23-30
24. Nelson L, Schwaner R (2009) Transdermal fentanyl: pharmacology and toxicology. J Med Toxicol 5:230-241
25. Plezia PM, Kramer TH, Linford J, Hameroff SR (1989) Transdermal fentanyl: pharmacokinetics and preliminary clinical evaluation. Pharmacotherapy 9:2-9
26. Varvel JR, Shafer SL, Hwang SS, Coen PA, Stanski DR (1989) Absorption characteristics of transdermally administered fentanyl. Anesthesiology 70:928-934