LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic® transdermal therapeutic systems

Forensic Science International

Volumn 169, Issue 2-3, 2007, Pages 223-227

  Coopman, Vera ^a   Cordonnier, Jan ^a   Pien, Karen ^b   Van Varenbergh, Dirk ^b  

^a Chemiphar NV   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Fentanyl; LC MS MS; Lethal intoxication; Transdermal

Indexed keywords

FENTANYL; NORFENTANYL; UNCLASSIFIED DRUG;

AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; FEMALE; HUMAN; IONIZATION; MICELLAR LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

EID: 34249740757     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2006.03.018     Document Type: Article

References (19)

1. ©J-C, 1998.
2. Karch S.B. Karch's Pathology of Drug Abuse. 3rd ed. (2002), CRC Press pp. 364-369
3. Radovanovic D., Pjevic M., Malbasa Z., and Stokic A. The use of transdermal fentanyl in the treatment of cancer pain. Arch. Oncol. 10 4 (2002) 263-266
4. Baselt R.C. Disposition of Toxic Drugs and Chemicals in Man. 6th ed. (2002), Biomedical Publications pp. 430-433
5. Henderson G.L. Fentanyl-related deaths: demographics, circumstances, and toxicology of 112 cases. J. Forensic Sci. 36 2 (1991) 422-433
6. ® transdermal patch: postmortem tissue distribution of fentanyl in 25 cases. J. Anal. Toxic. 24 (2000) 627-634
7. Pounder D.J., and Jones G.R. Postmortem drug redistribution-a toxicological nightmare. Forensic Sci. Int. 45 (1990) 253-263
8. Richardson T. Pitfalls in forensic toxicology. Ann. Clin. Biochem. 37 (2000) 20-44
9. Drummer O.H. Methods of analysis-postmortem. Encyclopedia of Forensic Sciences (2000), Academic Press pp. 1404-1409
10. Kuhlman J.J., McCaulley R., Valouch T.J., and Behonick G.S. Fentanyl use, misuse, and abuse: a summery of 23 postmortem cases. J. Anal. Toxic. 27 (2003) 499-504
11. Kramer C., and Tawney M. A fatal overdose of transdermally administered fentanyl. J. Am. Osteopath. Assoc. 7 (1998) 385-386
12. Hess R., Stiebler G., and Henz A. Pharmacokinetics of fentanyl in man and the rabbit. Eur. J. Clin. Pharmacol. 4 3 (1972) 137-141
13. Stoeckel H., Hengstmann J., and Schuttler J. Pharmacokinetics of fentantyl as a possible explanation for recurrence of respiratory depression. Br. J. Anest. 51 (1979) 741-745
14. Dvorchik S., and Vessel E.S. Pharmacokinitic interpretation of data gathered during therapeutic drug monitoring. Clin. Chem. 22 (1976) 868-878
15. Tharp A.M., Winecker R.E., and Winston D.C. Fatal intravenous fentanyl abuse. Four cases involving extraction of fentanyl from transdermal patches. Am. J. Forensic Med. Pathol. 25 (2004) 178-181
16. Reeves M.D., and Ginifer C.J. Fatal intravenous misuse of transdermal fentanyl. Med. J. Aust. 177 10 (2002) 552-554
17. Edinboro L.E., Poklis A., Trautman D., Lowry S., Backer R., and Harvey C.M. Fatal fentanyl intoxication following excessive transdermal application. J. Forensic Sci. 42 4 (1997) 741-743
18. Day J., Slawson M., Lugo R.A., and Wilkins D. Analysis of fentanyl and norfentanyl in human plasma by liquid chromatography-tandem mass spectrometry using electrospray ionization. J. Anal. Toxic. 27 (2003) 513-517
19. ® transdermal patches. J. Anal. Toxic. 28 (2004) 422-425