Postmortem redistribution of fentanyl in blood

American Journal of Clinical Pathology

Volumn 133, Issue 3, 2010, Pages 447-453

  Olson, Kalen N ^a   Luckenbill, Kristin ^a   Thompson, Jonathan ^b   Middleton, Owen ^b   Geiselhart, Roberta ^b   Mills, Kelly M ^c   Kloss, Julie ^a   Apple, Fred S ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Ramsey County Medical Examiner's Office   (United States)

Author keywords

Fentanyl; Forensic; Postmortem redistribution; Toxicology

Indexed keywords

ALCOHOL; ALPRAZOLAM; AMITRIPTYLINE; BENZODIAZEPINE DERIVATIVE; CITALOPRAM; COCAINE; DIPHENHYDRAMINE; FENTANYL; HOMOCOCAINE; HYDROMORPHONE; LAMOTRIGINE; MORPHINE; NORDAZEPAM; OXYCODONE; TRAMADOL; VENLAFAXINE; NARCOTIC AGENT;

ARTICLE; AUTOPSY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; FEMORAL ARTERY FLOW; HEART BLOOD VESSEL; HUMAN; LIVER; PRIORITY JOURNAL; SKELETAL MUSCLE; BLOOD; CADAVER; HEART MUSCLE; MASS FRAGMENTOGRAPHY; METABOLISM; TISSUE DISTRIBUTION;

AUTOPSY; FENTANYL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LIVER; MUSCLE, SKELETAL; MYOCARDIUM; NARCOTICS; POSTMORTEM CHANGES; TISSUE DISTRIBUTION;

EID: 77949408653     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/AJCP4X5VHFSOERFT     Document Type: Article

References (18)

1. Moriya F, Hashimoto Y. Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem. J Forensic Sci. 1999;44:10-16. (Pubitemid 29035763)
2. Pelissier-Alicot AL, Gaulier JM, Champsaur P, et al. Mechanisms underlying postmortem redistribution of drugs: a review. J Anal Toxicol. 2003;27:533-544. (Pubitemid 37500374)
3. Yarema MC, Becker CE. Key concepts in postmortem drug redistribution. Clin Toxicol (Phila). 2005;43:235-241.
4. Prouty RW, Anderson WH. The forensic science implications of site and temporal influences on postmortem blood-drug concentrations. J Forensic Sci. 1990;35:243-270.
5. Apple FS, Bandt CM. Liver and blood postmortem tricyclic antidepressant concentrations. Am J Clin Pathol. 1988;89:794-796.
6. Apple FS. Postmortem tricyclic antidepressant concentrations: assessing cause of death using parent drug to metabolite ratio. J Anal Toxicol. 1989;13:197-198.
7. Hilberg T, Rogde S, Morland J. Postmortem drug redistribution: human cases related to results in experimental animals. J Forensic Sci. 1999;44:3-9. (Pubitemid 29035762)
8. Yoshitome K, Miyaishi S, Yamamoto Y, et al. Postmortem increase of flecainide level in cardiac blood. J Anal Toxicol. 2008;32:451-453.
9. Logan BK, Smirnow D. Postmortem distribution and redistribution of morphine in man. J Forensic Sci. 1996;41:221-229. (Pubitemid 26087333)
10. Poklis A. Fentanyl: a review for clinical and analytical toxicologists. J Toxicol Clin Toxicol. 1995;33:439-447.
11. Hull MJ, Juhascik M, Mazur F, et al. Fatalities associated with fentanyl and co-administered cocaine or opiates. J Forensic Sci. 2007;52:1383-1388. (Pubitemid 350243437)
12. Kuhlman JJ Jr, McCaulley R, Valouch TJ, et al. Fentanyl use, misuse, and abuse: a summary of 23 postmortem cases. J Anal Toxicol. 2003;27:499-504. (Pubitemid 37185862)
13. Woodall KL, Martin TL, McLellan BA. Oral abuse of fentanyl patches (Duragesic): seven case reports. J Forensic Sci. 2008;53:222-225.
14. Thompson JG, Baker AM, Bracey AH, et al. Fentanyl concentrations in 23 postmortem cases from the Hennepin County Medical Examiner's office. J Forensic Sci. 2007;52:978-981.
15. Anderson DT, Muto JJ. Duragesic transdermal patch: postmortem tissue distribution of fentanyl in 25 cases. J Anal Toxicol. 2000;24:627-634.
16. Luckenbill K, Thompson J, Middleton O, et al. Fentanyl postmortem redistribution: preliminary findings regarding the relationship among femoral blood and liver and heart tissue concentrations. J Anal Toxicol. 2008;32:639-643.
17. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. 8th ed. Foster City, CA: Biomedical Publications; 2008.
18. Isenschmid DS, Hepler BR, Teem DM, et al. A rapid increase in fentanyl related deaths in Detroit: a twelve month review. Presented at the Annual Meeting of the American Academy of Forensic Sciences; February 22, 2007; San Antonio, TX.