메뉴 건너뛰기




Volumn 17, Issue 1, 2014, Pages 68-75

Thrombin generation in Cushing's Syndrome: Do the conventional clotting indices tell the whole truth?

Author keywords

Cushing's Syndrome; Metabolic Syndrome; Prothrombotic state; Thrombin generation

Indexed keywords

ADULT; AGED; AGED, 80 AND OVER; BLOOD COAGULATION; BLOOD COAGULATION TESTS; CUSHING SYNDROME; DIABETES COMPLICATIONS; DYSLIPIDEMIAS; FEMALE; HUMANS; HYDROCORTISONE; HYPERTENSION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; THROMBIN;

EID: 84895075748     PISSN: 1386341X     EISSN: 15737403     Source Type: Journal    
DOI: 10.1007/s11102-013-0467-3     Document Type: Article
Times cited : (24)

References (38)
  • 2
    • 0028339489 scopus 로고
    • Morbidity and mortality in Cushing's disease: An epidemiological approach
    • 10.1111/j.1365-2265.1994.tb02486.x
    • Extabe J, Vasquez JA (1994) Morbidity and mortality in Cushing's disease: an epidemiological approach. Clin Endocrinol 40:479-484
    • (1994) Clin Endocrinol , vol.40 , pp. 479-484
    • Extabe, J.1    Vasquez, J.A.2
  • 4
    • 33947513244 scopus 로고    scopus 로고
    • Mortality in patients treated for Cushing's disease is increased compared with patients treated for nonfunctioning pituitary macroadenoma
    • 1:CAS:528:DC%2BD2sXjtlGmsrw%3D 17200171 10.1210/jc.2006-2112
    • Dekkers OM, Biermasz NR, Pereira AM, Roelfsema F, Van Aken MO, Voormolen JHC, Romijn JA (2007) Mortality in patients treated for Cushing's disease is increased compared with patients treated for nonfunctioning pituitary macroadenoma. J Clin Endocrinol Metab 92:976-981
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 976-981
    • Dekkers, O.M.1    Biermasz, N.R.2    Pereira, A.M.3    Roelfsema, F.4    Van Aken, M.O.5    Voormolen, J.H.C.6    Romijn, J.A.7
  • 6
    • 79952284005 scopus 로고    scopus 로고
    • Mortality and morbidity in Cushing's disease over 50 years in Stoke-on-Trent, UK
    • 1:CAS:528:DC%2BC3MXjvFahsLc%3D 21193542 10.1210/jc.2010-1942
    • Clayton RN, Raskauskiene D, Reulen RC, Jones PW (2011) Mortality and morbidity in Cushing's disease over 50 years in Stoke-on-Trent, UK. J Clin Endocrinol Metab 96:632-642
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 632-642
    • Clayton, R.N.1    Raskauskiene, D.2    Reulen, R.C.3    Jones, P.W.4
  • 8
    • 84859089421 scopus 로고    scopus 로고
    • Pathogenesis of vascular complications in Cushing's Syndrome. Review
    • 22450342
    • Miljic P, Miljic D, Cain JW, Korbonits M, Popovic V (2012) Pathogenesis of vascular complications in Cushing's Syndrome. Review. Hormones 11:21-30
    • (2012) Hormones , vol.11 , pp. 21-30
    • Miljic, P.1    Miljic, D.2    Cain, J.W.3    Korbonits, M.4    Popovic, V.5
  • 9
    • 77957836538 scopus 로고    scopus 로고
    • Changes of coagulation indexes and occurrence of venous thromboembolism in patients with Cushing's Syndrome: Results from a retrospective study before and after surgery
    • 1:CAS:528:DC%2BC3cXhsVWqur3N 10.1530/EJE-10-0583
    • Manetti L, Bogazzi F, Giovannetti C, Raffaelli V, Genovesi M, Pellegrini G, Ruocco L, Iannelli A, Martino E (2010) Changes of coagulation indexes and occurrence of venous thromboembolism in patients with Cushing's Syndrome: results from a retrospective study before and after surgery. Euro J Endocrinol 163:783-791
    • (2010) Euro J Endocrinol , vol.163 , pp. 783-791
    • Manetti, L.1    Bogazzi, F.2    Giovannetti, C.3    Raffaelli, V.4    Genovesi, M.5    Pellegrini, G.6    Ruocco, L.7    Iannelli, A.8    Martino, E.9
  • 10
    • 0034001980 scopus 로고    scopus 로고
    • Markers of activation of coagulation and fibrinolysis in patients with Cushing's Syndrome
    • 1:STN:280:DC%2BD3c3mtVKjtA%3D%3D 10803470
    • Fatti LM, Bottasso B, Invitti C, Coppola R, Cavanigni F, Mannucci PM (2000) Markers of activation of coagulation and fibrinolysis in patients with Cushing's Syndrome. J Endocrinol Invest 23:145-150
    • (2000) J Endocrinol Invest , vol.23 , pp. 145-150
    • Fatti, L.M.1    Bottasso, B.2    Invitti, C.3    Coppola, R.4    Cavanigni, F.5    Mannucci, P.M.6
  • 11
    • 0029085314 scopus 로고
    • Thrombin generation in plasma: Its assessment via the endogenous thrombin potential
    • 1:CAS:528:DyaK2MXnvVSrtbk%3D 8578446
    • Hemker HC, Beguin S (1995) Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 74:134-138
    • (1995) Thromb Haemost , vol.74 , pp. 134-138
    • Hemker, H.C.1    Beguin, S.2
  • 13
    • 0242575183 scopus 로고    scopus 로고
    • Thrombin generation in severe haemophilia A and B: The endogenous thrombin potential in platelet-rich plasma
    • 1:CAS:528:DC%2BD3sXptVynuro%3D 14597971
    • Siegemund T, Petros S, Siegemund A, Scholz U, Engelmann L (2003) Thrombin generation in severe haemophilia A and B: the endogenous thrombin potential in platelet-rich plasma. Thromb Haemost 90:781-786
    • (2003) Thromb Haemost , vol.90 , pp. 781-786
    • Siegemund, T.1    Petros, S.2    Siegemund, A.3    Scholz, U.4    Engelmann, L.5
  • 14
    • 0037085806 scopus 로고    scopus 로고
    • Randomized trial of different regimens of heparins and in vivo thrombin generation in acute deep vein thrombosis
    • 1:CAS:528:DC%2BD38XitF2nt7s%3D 11877267 10.1182/blood.V99.6.1965
    • Kakkar VV, Hoppenstead DA, Fareed J, Kadziola Z, Scully M, Nakov R, Breddin HK (2002) Randomized trial of different regimens of heparins and in vivo thrombin generation in acute deep vein thrombosis. Blood 99:1965-1970
    • (2002) Blood , vol.99 , pp. 1965-1970
    • Kakkar, V.V.1    Hoppenstead, D.A.2    Fareed, J.3    Kadziola, Z.4    Scully, M.5    Nakov, R.6    Breddin, H.K.7
  • 16
    • 0036095699 scopus 로고    scopus 로고
    • Reduced von Willebrand factor survival in type vicenza von Willebrand disease
    • 1:CAS:528:DC%2BD38XivF2hsw%3D%3D 11756169 10.1182/blood.V99.1.180
    • Casonato A, Pontara E, Sartorello F, Cattini MG, Sartori MT, Padrini R, Girolami A (2002) Reduced von Willebrand factor survival in type vicenza von Willebrand disease. Blood 99:180-184
    • (2002) Blood , vol.99 , pp. 180-184
    • Casonato, A.1    Pontara, E.2    Sartorello, F.3    Cattini, M.G.4    Sartori, M.T.5    Padrini, R.6    Girolami, A.7
  • 18
    • 0033510180 scopus 로고    scopus 로고
    • The molecular genetics of familial venous thrombosis
    • 1:STN:280:DC%2BD3czhtFSquw%3D%3D 10856982 10.1053/beha.1999.0037
    • Simioni P (1999) The molecular genetics of familial venous thrombosis. Baillieres Best Pract Res Clin Haematol 12:479-503
    • (1999) Baillieres Best Pract Res Clin Haematol , vol.12 , pp. 479-503
    • Simioni, P.1
  • 19
    • 69549137883 scopus 로고    scopus 로고
    • The role of antiphospholipid antibodies toward the protein C/protein S system in venous thromboembolic disease
    • 1:CAS:528:DC%2BD1MXhtFOktLbN 19565645 10.1002/ajh.21466
    • Rossetto V, Spiezia L, Franz F, Salmaso L, Pozza LV, Gavasso S, Simioni P (2009) The role of antiphospholipid antibodies toward the protein C/protein S system in venous thromboembolic disease. Am J Hematol 84:594-596
    • (2009) Am J Hematol , vol.84 , pp. 594-596
    • Rossetto, V.1    Spiezia, L.2    Franz, F.3    Salmaso, L.4    Pozza, L.V.5    Gavasso, S.6    Simioni, P.7
  • 21
    • 77957714048 scopus 로고    scopus 로고
    • Haemostatic alterations in overweight children: Associations between Metabolic Syndrome, thrombin generation, and fibrinogen levels
    • 1:CAS:528:DC%2BC3cXht1OgurzK 20619835 10.1016/j.atherosclerosis.2010.06. 028
    • Fritsch P, Kleber M, Rosenkranz A, Fritsch M, Muntean W, Mangge H, Reinehr T (2010) Haemostatic alterations in overweight children: associations between Metabolic Syndrome, thrombin generation, and fibrinogen levels. Atherosclerosis 212:650-655
    • (2010) Atherosclerosis , vol.212 , pp. 650-655
    • Fritsch, P.1    Kleber, M.2    Rosenkranz, A.3    Fritsch, M.4    Muntean, W.5    Mangge, H.6    Reinehr, T.7
  • 23
    • 79951723277 scopus 로고    scopus 로고
    • Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay
    • 1:CAS:528:DC%2BC3MXpvFWitw%3D%3D 20640482 10.1007/s11239-010-0506-0
    • Tripodi A, Branchi A, Chantarangkul V, Clerici M, Merati G, Artoni A, Mannucci PM (2011) Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay. J Thromb Thrombolysis 31:165-172
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 165-172
    • Tripodi, A.1    Branchi, A.2    Chantarangkul, V.3    Clerici, M.4    Merati, G.5    Artoni, A.6    Mannucci, P.M.7
  • 24
    • 67649373249 scopus 로고    scopus 로고
    • Blood coagulation and fibrinolysis in patients with Cushing's Syndrome: Increased plasminogen activator inhibitor-1, decreased tissue factor pathway inhibitor and unchanged thrombin-activatable fibrinolysis inhibitor levels
    • 1:CAS:528:DC%2BD1MXot1Ght7w%3D 19411818
    • Erem C, Nuhoglu I, Yilmaz M, Kocak M, Demirel A, Ucuncu O, Onder Ersoz H (2009) Blood coagulation and fibrinolysis in patients with Cushing's Syndrome: increased plasminogen activator inhibitor-1, decreased tissue factor pathway inhibitor and unchanged thrombin-activatable fibrinolysis inhibitor levels. J Endocrinol Invest 32:169-174
    • (2009) J Endocrinol Invest , vol.32 , pp. 169-174
    • Erem, C.1    Nuhoglu, I.2    Yilmaz, M.3    Kocak, M.4    Demirel, A.5    Ucuncu, O.6    Onder Ersoz, H.7
  • 26
    • 70349578944 scopus 로고    scopus 로고
    • Hypercoagulability in Cushing's Syndrome: The role of specific haemostatic and fibrinolytic markers
    • 1:CAS:528:DC%2BD1MXpsFOmsrg%3D 19381886 10.1007/s12020-009-9186-y
    • Kastelan D, Dusek T, Kraljevic I, Polasek O, Giljevic Z, Solak M, Salek SZ, Jelcic J, Korsic M (2009) Hypercoagulability in Cushing's Syndrome: the role of specific haemostatic and fibrinolytic markers. Endocrine 36:70-74
    • (2009) Endocrine , vol.36 , pp. 70-74
    • Kastelan, D.1    Dusek, T.2    Kraljevic, I.3    Polasek, O.4    Giljevic, Z.5    Solak, M.6    Salek, S.Z.7    Jelcic, J.8    Korsic, M.9
  • 27
    • 0037231552 scopus 로고    scopus 로고
    • The dynamics of thrombin formation
    • 1:CAS:528:DC%2BD3sXhvVY%3D 12524220 10.1161/01.ATV.0000046238.23903.FC
    • Mann KG, Butenas S, Brummel K (2003) The dynamics of thrombin formation. Arterioscl Thromb Vasc Biol 23:17-25
    • (2003) Arterioscl Thromb Vasc Biol , vol.23 , pp. 17-25
    • Mann, K.G.1    Butenas, S.2    Brummel, K.3
  • 29
    • 0035278831 scopus 로고    scopus 로고
    • Factor VII, tissue factor pathway inhibitor, and monocyte tissue factor in diabetes mellitus: Influence of type of diabetes, obesity index, and age
    • 1:CAS:528:DC%2BD3MXisF2gsLs%3D 11297753 10.1016/S0049-3848(00)00424-2
    • Vambergue A, Rugeri L, Gaveriaux V, Devos P, Martin A, Fermon C, Fontaine P, Jude B (2001) Factor VII, tissue factor pathway inhibitor, and monocyte tissue factor in diabetes mellitus: influence of type of diabetes, obesity index, and age. Thromb Res 101:367-375
    • (2001) Thromb Res , vol.101 , pp. 367-375
    • Vambergue, A.1    Rugeri, L.2    Gaveriaux, V.3    Devos, P.4    Martin, A.5    Fermon, C.6    Fontaine, P.7    Jude, B.8
  • 30
    • 0042905228 scopus 로고    scopus 로고
    • Low tissue factor pathway inhibitor (TFPI) together with low antithrombin allows sufficient thrombin generation in neonates
    • 1:CAS:528:DC%2BD2cXktFenu7c%3D 10.1046/j.1538-7836.2003.00081.x
    • Cvirn G, Gallistl S, Leschnik B, Muntean W (2003) Low tissue factor pathway inhibitor (TFPI) together with low antithrombin allows sufficient thrombin generation in neonates. J Thromb and Haemost 1:263-268
    • (2003) J Thromb and Haemost , vol.1 , pp. 263-268
    • Cvirn, G.1    Gallistl, S.2    Leschnik, B.3    Muntean, W.4
  • 32
    • 34247554276 scopus 로고    scopus 로고
    • Elevated prothrombin level and shortened clotting times in subjects with type 2 diabetes
    • 1:CAS:528:DC%2BD2sXktFCis74%3D 17166250 10.1111/j.1538-7836.2007.02366.x
    • Sauls DL, Banini AE, Boyd LC, Hoffman M (2007) Elevated prothrombin level and shortened clotting times in subjects with type 2 diabetes. J Thromb Haemost 5:638-639
    • (2007) J Thromb Haemost , vol.5 , pp. 638-639
    • Sauls, D.L.1    Banini, A.E.2    Boyd, L.C.3    Hoffman, M.4
  • 33
    • 0032927792 scopus 로고    scopus 로고
    • Abnormalities in von Willebrand factor are also part of the prothrombotic state of Cushing's Syndrome
    • 1:STN:280:DyaK1M3otl2jsw%3D%3D 10357009 10.1097/00001721-199904000-00006
    • Casonato A, Pontara E, Boscaro M, Sonino N, Sartorello F, Ferasin S, Girolami A (1999) Abnormalities in von Willebrand factor are also part of the prothrombotic state of Cushing's Syndrome. Blood Coagul Fibrinolysis 10:145-151
    • (1999) Blood Coagul Fibrinolysis , vol.10 , pp. 145-151
    • Casonato, A.1    Pontara, E.2    Boscaro, M.3    Sonino, N.4    Sartorello, F.5    Ferasin, S.6    Girolami, A.7
  • 34
    • 0028814316 scopus 로고
    • Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis
    • 1:STN:280:DyaK2M7isVShsw%3D%3D 7823669 10.1016/S0140-6736(95)90166-3
    • Koster T, Blann AD, Briet E, Vandenbroucke JP, Rosendaal FR (1995) Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 345:152-155
    • (1995) Lancet , vol.345 , pp. 152-155
    • Koster, T.1    Blann, A.D.2    Briet, E.3    Vandenbroucke, J.P.4    Rosendaal, F.R.5
  • 35
    • 1242269966 scopus 로고    scopus 로고
    • High plasma levels of factor VIII and risk of recurrence of venous thromboembolism
    • 14984502 10.1046/j.1365-2141.2003.04795.x
    • Cristina L, Benilde C, Michela C, Mirella F, Giuliana G, Gualtiero P (2004) High plasma levels of factor VIII and risk of recurrence of venous thromboembolism. Br J Haematol 124:504-510
    • (2004) Br J Haematol , vol.124 , pp. 504-510
    • Cristina, L.1    Benilde, C.2    Michela, C.3    Mirella, F.4    Giuliana, G.5    Gualtiero, P.6
  • 37
    • 48949102232 scopus 로고    scopus 로고
    • Assessment of thrombin generation II: Validation of the Calibrated Automated Thrombogram in platelet-poor plasma in a clinical laboratory
    • 1:CAS:528:DC%2BD1cXhtV2it7fE 18690360
    • Spronk HM, Dielis AW, De Smedt E, Van Oerle R, Fens D, Prins MH, Hamulyák K, Ten Cate H (2008) Assessment of thrombin generation II: validation of the Calibrated Automated Thrombogram in platelet-poor plasma in a clinical laboratory. Thromb Haemost 100(2):362-364
    • (2008) Thromb Haemost , vol.100 , Issue.2 , pp. 362-364
    • Spronk, H.M.1    Dielis, A.W.2    De Smedt, E.3    Van Oerle, R.4    Fens, D.5    Prins, M.H.6    Hamulyák, K.7    Ten Cate, H.8
  • 38
    • 79251495773 scopus 로고    scopus 로고
    • Thrombin generation tests
    • 1:CAS:528:DC%2BC3MXivVWgsLc%3D 21262433 10.1016/S0049-3848(11)70007-X
    • Castoldi E, Rosing J (2011) Thrombin generation tests. Thromb Res 127:S21-S25
    • (2011) Thromb Res , vol.127
    • Castoldi, E.1    Rosing, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.