Haemostatic alterations in overweight children: Associations between metabolic syndrome, thrombin generation, and fibrinogen levels

Atherosclerosis

Volumn 212, Issue 2, 2010, Pages 650-655

  Fritsch, P ^b   Kleber, M ^a   Rosenkranz, A ^b   Fritsch, M ^c   Muntean, W ^b   Mangge, H ^b   Reinehr, T ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Blood pressure; Fibrinogen; Insulin resistance; Lipids; Obesity; Thrombin generation test

Indexed keywords

FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ADOLESCENT; ARTICLE; BLOOD CLOTTING TEST; BLOOD PRESSURE MEASUREMENT; BODY MASS; BODY WEIGHT; CHILD; CHILDHOOD DISEASE; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; FIBRINOGEN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; THROMBIN TIME; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADOLESCENT; BLOOD PRESSURE; BODY WEIGHT; CHILD; FEMALE; FIBRINOGEN; HEMOSTASIS; HUMANS; INSULIN RESISTANCE; LIPIDS; MALE; METABOLIC SYNDROME X; OBESITY; OVERWEIGHT; PROSPECTIVE STUDIES; THROMBIN;

EID: 77957714048     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.06.028     Document Type: Article

References (39)

1. Isomaa B., Almgren P., Tuomi T., et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001, 24:683-689.
2. Reaven G.M. Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease. Am Heart J 1991, 121:1283-1288.
3. Kohler H.P. Insulin resistance syndrome: interaction with coagulation and fibrinolysis. Swiss Med Wkly 2002, 132:241-252.
4. Dentali F., Romualdi E., Ageno W. The metabolic syndrome and the risk of thrombosis. Haematologica 2007, 92:297-299.
5. Dentali F., Squizzato A., Ageno W. The metabolic syndrome as a risk factor for venous and arterial thrombosis. Semin Thromb Hemost 2009, 35:451-457.
6. Anand S.S., Yi Q., Gerstein H., et al. Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease. Circulation 2003, 108:420-425.
7. Nieuwdorp M., Stroes E.S., Meijers J.C., Buller H. Hypercoagulability in the metabolic syndrome. Curr Opin Pharmacol 2005, 5:155-159.
8. Balagopal P., Sweeten S., Mauras N. Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescents. Am J Physiol Endocrinol Metab 2002, 282:E899-E904.
9. Balagopal P., George D., Sweeten S., et al. Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D-dimer and fibrinolytic balance to physical activity-based intervention in obese children. J Thromb Haemost 2008, 6:1296-1303.
10. Balagopal P., George D., Patton N., et al. Lifestyle-only intervention attenuates the inflammatory state associated with obesity: a randomized controlled study in adolescents. J Pediatr 2005, 146:342-348.
11. Ferguson M.A., Gutin B., Owens S., et al. Effects of physical training and its cessation on the hemostatic system of obese children. Am J Clin Nutr 1999, 69:1130-1134.
12. Steffen L.M., Cushman M., Peacock J.M., et al. Metabolic syndrome and risk of venous thromboembolism: longitudinal investigation of thromboembolism etiology. J Thromb Haemost 2009, 7:746-751.
13. Valle J.M., Estepa R.M., Camacho R.M., et al. Endothelial dysfunction is related to insulin resistance and inflammatory biomarker levels in obese prepubertal children. Eur J Endocrinol 2007, 156:497-502.
14. Cimenti C., Mangge H., Haidl H., Zach D., Muntean W. Thrombin generation in severely obese children. J Thromb Haemost 2006, 4:1834-1836.
15. Reinehr T., Kleber M., Toschke A.M. Lifestyle intervention in obese children is associated with a decrease of the metabolic syndrome prevalence. Atherosclerosis 2009, 207:174-180.
16. Reinehr T., Kiess W., de S.G., Stoffel-Wagner B., Wunsch R. Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006, 55:113-118.
17. Reinehr T., Wunsch R., de S.G., Toschke A.M. Relationship between metabolic syndrome definitions for children and adolescents and intima-media thickness. Atherosclerosis 2008, 199:193-200.
18. Mangge H., Almer G., Haj-Yahya S., et al. Preatherosclerosis and adiponectin subfractions in obese adolescents. Obesity (Silver Spring) 2008, 16:2578-2584.
19. Marshall W.A., Tanner J.M. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969, 44:291-303.
20. Marshall W.A., Tanner J.M. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970, 45:13-23.
21. Cole T.J. The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990, 44:45-60.
22. Kromeyer-Hauschild K., Wabitsch M., Geller F., et al. Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd 2001, 149:807-818.
23. National High Blood Pressure Education Program on High Blood Pressure in Children Adolescents The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004, 114:555-576.
24. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
25. Genuth S., Alberti K.G., Bennett P., et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003, 26:3160-3167.
26. Zimmet P., Alberti K.G., Kaufman F., et al. The metabolic syndrome in children and adolescents-an IDF consensus report. Pediatr Diabetes 2007, 8:299-306.
27. Kromeyer-Hausschild K., Gläßer N., Zellner K. Waist Circumference percentile in Jena children (Germany) 6 to 18 years of age. Aktuel Ernaehr Med 2008, 33:116-122.
28. Hemker H.C., Giesen P., Al D.R., et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003, 33:4-15.
29. Duchemin J., Pan-Petesch B., Arnaud B., Blouch M.T., Abgrall J.F. Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma. Thromb Haemost 2008, 99:767-773.
30. De P.G., Pannacciulli N. Coagulation fibrinolysis abnormalities in obesity. J Endocrinol Invest 2002, 25:899-904.
31. Skurk T., Hauner H. Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1. Int J Obes Relat Metab Disord 2004, 28:1357-1364.
32. Mertens I., Van Gaal L.F. Obesity, haemostasis and the fibrinolytic system. Obes Rev 2002, 3:85-101.
33. Csabi G., Torok K., Jeges S., Molnar D. Presence of metabolic cardiovascular syndrome in obese children. Eur J Pediatr 2000, 159:91-94.
34. Weiss R., Dziura J., Burgert T.S., et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004, 350:2362-2374.
35. Ay L., Kopp H.P., Brix J.M., et al. Thrombin generation in morbid obesity: significant reduction after weight loss. J Thromb Haemost 2010, 8:759-765.
36. Sakkinen P.A., Wahl P., Cushman M., Lewis M.R., Tracy R.P. Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome. Am J Epidemiol 2000, 152:897-907.
37. Mertens I., Van Gaal L.F. Visceral fat as a determinant of fibrinolysis and hemostasis. Semin Vasc Med 2005, 5:48-55.
38. Ragab A., Abousamra N.K., Higazy A., Saleh O. Relationship between insulin resistance and some coagulation and fibrinolytic parameters in patients with metabolic syndrome. Lab Hematol 2008, 14:1-6.
39. Wallace T.M., Matthews D.R. The assessment of insulin resistance in man. Diabet Med 2002, 19:527-534.