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Volumn 45, Issue 1, 2014, Pages 103-112

Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse

Author keywords

Hedgehog; IKK ; Liver fibrosis; MicroRNA 29; NF B

Indexed keywords

ANIMALS; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION; HEDGEHOG PROTEINS; HEPATIC STELLATE CELLS; I-KAPPA B KINASE; LIVER CIRRHOSIS; MICE; MICE, KNOCKOUT; MICRORNAS; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84895074732     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-013-9532-5     Document Type: Article
Times cited : (25)

References (38)
  • 1
    • 3042645799 scopus 로고    scopus 로고
    • The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats
    • 15219682 10.1016/j.neuroscience.2004.04.051
    • Bär KJ, Schurigt U, Scholze A, von Banchet GS, Stopfel N, Bräuer R, Halbhuber KJ, Schaible HG (2004) The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats. Neuroscience 127(1):197-206
    • (2004) Neuroscience , vol.127 , Issue.1 , pp. 197-206
    • Bär, K.J.1    Schurigt, U.2    Scholze, A.3    Von Banchet, G.S.4    Stopfel, N.5    Bräuer, R.6    Halbhuber, K.J.7    Schaible, H.G.8
  • 2
    • 85035392112 scopus 로고    scopus 로고
    • Liver fibrosis
    • 1:CAS:528:DC%2BD2MXhtFyjs70%3D 546435 15690074
    • Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115(2):209-218
    • (2005) J Clin Invest , vol.115 , Issue.2 , pp. 209-218
    • Bataller, R.1    Brenner, D.A.2
  • 3
    • 73149101056 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transitions in the liver
    • 1:CAS:528:DC%2BD1MXhs1SjurnO 2787916 19824076 10.1002/hep.23196
    • Choi SS, Diehl AM (2009) Epithelial-to-mesenchymal transitions in the liver. Hepatology 50(6):2007-2013
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 2007-2013
    • Choi, S.S.1    Diehl, A.M.2
  • 5
    • 84862798586 scopus 로고    scopus 로고
    • Recombinant fusion protein of albumin-retinol binding protein inactivates stellate cells
    • 1:CAS:528:DC%2BC38XhvFartr4%3D 22266308 10.1016/j.bbrc.2012.01.012
    • Choi S, Park S, Kim S, Lim C, Kim J, Cha DR, Oh J (2012) Recombinant fusion protein of albumin-retinol binding protein inactivates stellate cells. Biochem Biophys Res Commun 418(1):191-197
    • (2012) Biochem Biophys Res Commun , vol.418 , Issue.1 , pp. 191-197
    • Choi, S.1    Park, S.2    Kim, S.3    Lim, C.4    Kim, J.5    Cha, D.R.6    Oh, J.7
  • 6
    • 34247619364 scopus 로고    scopus 로고
    • Gene expression profiles during hepatic stellate cell activation in culture and in vivo
    • 17484886 10.1053/j.gastro.2007.02.033
    • De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF (2007) Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 132(5):1937-1946
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1937-1946
    • De Minicis, S.1    Seki, E.2    Uchinami, H.3    Kluwe, J.4    Zhang, Y.5    Brenner, D.A.6    Schwabe, R.F.7
  • 7
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • 1:CAS:528:DC%2BD2MXpvV2htLY%3D 16151628 10.1007/s10495-005-1055-4
    • Elsharkawy A, Oakley F, Mann D (2005) The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 10(5):927-939
    • (2005) Apoptosis , vol.10 , Issue.5 , pp. 927-939
    • Elsharkawy, A.1    Oakley, F.2    Mann, D.3
  • 8
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-κB: Players, pathways, perspectives
    • 1:CAS:528:DC%2BD28XhtFektL7E 17072321 10.1038/sj.onc.1209954
    • Gilmore TD (2006) Introduction to NF-κB: players, pathways, perspectives. Oncogene 25(51):6680-6684
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6680-6684
    • Gilmore, T.D.1
  • 9
    • 0029999656 scopus 로고    scopus 로고
    • Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis
    • 1:CAS:528:DyaK28XktVCqtbw%3D 8698809 10.1083/jcb.134.1.13
    • Grimm S, Bauer M, Baeuerle PA, Schulze-Osthoff K (1996) Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J Cell Biol 134(1):13-23
    • (1996) J Cell Biol , vol.134 , Issue.1 , pp. 13-23
    • Grimm, S.1    Bauer, M.2    Baeuerle, P.A.3    Schulze-Osthoff, K.4
  • 10
    • 69449087939 scopus 로고    scopus 로고
    • Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways
    • 1:CAS:528:DC%2BD1MXhtFChtrnP 19674103 10.1111/j.1742-4658.2009.07213.x
    • Guo CJ, Pan Q, Cheng T, Jiang B, Chen GY, Li DG (2009) Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J 276(18):5163-5176
    • (2009) FEBS J , vol.276 , Issue.18 , pp. 5163-5176
    • Guo, C.J.1    Pan, Q.2    Cheng, T.3    Jiang, B.4    Chen, G.Y.5    Li, D.G.6
  • 11
    • 17144431776 scopus 로고    scopus 로고
    • Communicating with hedgehogs
    • 1:CAS:528:DC%2BD2MXivVaktLs%3D 15803137 10.1038/nrm1622
    • Hooper JE, Scott MP (2005) Communicating with hedgehogs. Nat Rev Mol Cell Biol 6(4):306-317
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.4 , pp. 306-317
    • Hooper, J.E.1    Scott, M.P.2
  • 12
    • 77951722845 scopus 로고    scopus 로고
    • Signals from dying hepatocytes trigger growth of liver progenitors
    • 1:CAS:528:DC%2BC3cXnvFKhsrk%3D 3632642 20427400 10.1136/gut.2009.204354
    • Jung Y, Witek RP, Syn WK, Choi SS, Omenetti A, Premont R, Guy CD, Diehl AM (2010) Signals from dying hepatocytes trigger growth of liver progenitors. Gut 59(5):655-665
    • (2010) Gut , vol.59 , Issue.5 , pp. 655-665
    • Jung, Y.1    Witek, R.P.2    Syn, W.K.3    Choi, S.S.4    Omenetti, A.5    Premont, R.6    Guy, C.D.7    Diehl, A.M.8
  • 13
    • 70349303936 scopus 로고    scopus 로고
    • Formation of vitamin A lipid droplets in pancreatic stellate cells requires albumin
    • 1:CAS:528:DC%2BD1MXhtlSks7nF 19293176 10.1136/gut.2008.170233
    • Kim N, Yoo W, Lee J, Kim H, Lee H, Kim Y-S, Kim D-U, Oh J (2009) Formation of vitamin A lipid droplets in pancreatic stellate cells requires albumin. Gut 58(10):1382-1390
    • (2009) Gut , vol.58 , Issue.10 , pp. 1382-1390
    • Kim, N.1    Yoo, W.2    Lee, J.3    Kim, H.4    Lee, H.5    Kim, Y.-S.6    Kim, D.-U.7    Oh, J.8
  • 14
    • 84866286931 scopus 로고    scopus 로고
    • Mir-29, inhibiting synthesis of profibrogenic mediators, is released into the blood stream after chronic hepatitis C infection, indicating progression of fibrosis
    • Kwiecinski M, Elfimova N, Noetel A, Schievenbusch S, Strack I, Toex U, Drebber U, Steffen H, Dienes H, Odenthal M (2010) Mir-29, inhibiting synthesis of profibrogenic mediators, is released into the blood stream after chronic hepatitis C infection, indicating progression of fibrosis. Hepatology 52(4 Suppl):446A-447A
    • (2010) Hepatology , vol.52 , Issue.4 SUPPL.
    • Kwiecinski, M.1    Elfimova, N.2    Noetel, A.3    Schievenbusch, S.4    Strack, I.5    Toex, U.6    Drebber, U.7    Steffen, H.8    Dienes, H.9    Odenthal, M.10
  • 15
    • 0346094457 scopus 로고    scopus 로고
    • Prediction of mammalian microRNA targets
    • 1:CAS:528:DC%2BD2cXhsFCnsw%3D%3D 14697198 10.1016/S0092-8674(03)01018-3
    • Lewis BP, Shih I, Jones-Rhoades MW, Bartel DP, Burge CB (2003) Prediction of mammalian microRNA targets. Cell 115(7):787-798
    • (2003) Cell , vol.115 , Issue.7 , pp. 787-798
    • Lewis, B.P.1    Shih, I.2    Jones-Rhoades, M.W.3    Bartel, D.P.4    Burge, C.B.5
  • 16
    • 73449149063 scopus 로고    scopus 로고
    • Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress
    • 1:CAS:528:DC%2BD1MXhsFejtb3J 19956414
    • Luna C, Li G, Qiu J, Epstein DL, Gonzalez P (2009) Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress. Mol Vis 15:2488
    • (2009) Mol Vis , vol.15 , pp. 2488
    • Luna, C.1    Li, G.2    Qiu, J.3    Epstein, D.L.4    Gonzalez, P.5
  • 17
    • 21244472975 scopus 로고    scopus 로고
    • IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • 1:CAS:528:DC%2BD2MXmtF2nsbo%3D 15989949 10.1016/j.cell.2005.04.014
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M (2005) IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-990
    • (2005) Cell , vol.121 , Issue.7 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 18
    • 0037158513 scopus 로고    scopus 로고
    • Activation of NF-kB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications
    • 1:CAS:528:DC%2BD38XntVait7o%3D 12173037 10.1038/sj.onc.1205664
    • Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG (2002) Activation of NF-kB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene 21(37):5673-5683
    • (2002) Oncogene , vol.21 , Issue.37 , pp. 5673-5683
    • Mitsiades, C.S.1    Mitsiades, N.2    Poulaki, V.3    Schlossman, R.4    Akiyama, M.5    Chauhan, D.6    Hideshima, T.7    Treon, S.P.8    Munshi, N.C.9    Richardson, P.G.10
  • 19
    • 34548687035 scopus 로고    scopus 로고
    • Mir-29 regulates Mcl-1 protein expression and apoptosis
    • 1:CAS:528:DC%2BD2sXhtVeisLvJ 2432524 17404574 10.1038/sj.onc.1210436
    • Mott JL, Kobayashi S, Bronk SF, Gores GJ (2007) Mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26(42):6133-6140
    • (2007) Oncogene , vol.26 , Issue.42 , pp. 6133-6140
    • Mott, J.L.1    Kobayashi, S.2    Bronk, S.F.3    Gores, G.J.4
  • 20
    • 77954950168 scopus 로고    scopus 로고
    • Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB
    • 1:CAS:528:DC%2BC3cXovFOjtL4%3D 2922950 20564213 10.1002/jcb.22630
    • Mott JL, Kurita S, Cazanave SC, Bronk SF, Werneburg NW, Fernandez-Zapico ME (2010) Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem 110(5):1155-1164
    • (2010) J Cell Biochem , vol.110 , Issue.5 , pp. 1155-1164
    • Mott, J.L.1    Kurita, S.2    Cazanave, S.C.3    Bronk, S.F.4    Werneburg, N.W.5    Fernandez-Zapico, M.E.6
  • 21
    • 62849092266 scopus 로고    scopus 로고
    • NF-κB in liver diseases: A target for drug therapy
    • 1:CAS:528:DC%2BD1MXivVejs7s%3D 18937212 10.1002/jat.1393
    • Muriel P (2009) NF-κB in liver diseases: a target for drug therapy. J Appl Toxicol 29(2):91-100
    • (2009) J Appl Toxicol , vol.29 , Issue.2 , pp. 91-100
    • Muriel, P.1
  • 22
    • 72949109956 scopus 로고    scopus 로고
    • Suppression of type i collagen production by microRNA-29b in cultured human stellate cells
    • 1:CAS:528:DC%2BC3cXptl2q 19913496 10.1016/j.bbrc.2009.11.056
    • Ogawa T, Iizuka M, Sekiya Y, Yoshizato K, Ikeda K, Kawada N (2010) Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem Biophys Res Commun 391(1):316-321
    • (2010) Biochem Biophys Res Commun , vol.391 , Issue.1 , pp. 316-321
    • Ogawa, T.1    Iizuka, M.2    Sekiya, Y.3    Yoshizato, K.4    Ikeda, K.5    Kawada, N.6
  • 24
    • 78751585439 scopus 로고    scopus 로고
    • Hedgehog signaling in the liver
    • 1:CAS:528:DC%2BC3MXmsVyrsg%3D%3D 3053023 21093090 10.1016/j.jhep.2010.10. 003
    • Omenetti A, Choi S, Michelotti G, Diehl AM (2011) Hedgehog signaling in the liver. J Hepatol 54(2):366-373
    • (2011) J Hepatol , vol.54 , Issue.2 , pp. 366-373
    • Omenetti, A.1    Choi, S.2    Michelotti, G.3    Diehl, A.M.4
  • 25
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-κB and IKK function
    • 1:CAS:528:DC%2BD28XhtlCjt7bK 17183360 10.1038/nrm2083
    • Perkins ND (2007) Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol 8(1):49-62
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.1 , pp. 49-62
    • Perkins, N.D.1
  • 27
    • 0036551274 scopus 로고    scopus 로고
    • Activation of hepatic stellate cells-a key issue in liver fibrosis
    • 10.2741/reeves
    • Reeves HL, Friedman SL (2002) Activation of hepatic stellate cells-a key issue in liver fibrosis. Front Biosci 7(4):808-826
    • (2002) Front Biosci , vol.7 , Issue.4 , pp. 808-826
    • Reeves, H.L.1    Friedman, S.L.2
  • 29
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-kB in p53-mediated programmed cell death
    • 1:CAS:528:DC%2BD3cXjtVCrtbg%3D 10786798 10.1038/35009130
    • Ryan KM, Ernst MK, Rice NR, Vousden KH (2000) Role of NF-kB in p53-mediated programmed cell death. Nature 404(6780):892-896
    • (2000) Nature , vol.404 , Issue.6780 , pp. 892-896
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3    Vousden, K.H.4
  • 33
    • 0032562085 scopus 로고    scopus 로고
    • Cytokine induced expression of porcine inhibitor of apoptosis protein (IAP) family member is regulated by NF-B
    • 1:CAS:528:DyaK1cXhsFCgtLk%3D 9501011 10.1006/bbrc.1998.8185
    • Stehlik C, de Martin R, Binder BR, Lipp J (1998) Cytokine induced expression of porcine inhibitor of apoptosis protein (IAP) family member is regulated by NF-B. Biochem Biophys Res Commun 243(3):827-832
    • (1998) Biochem Biophys Res Commun , vol.243 , Issue.3 , pp. 827-832
    • Stehlik, C.1    De Martin, R.2    Binder, B.R.3    Lipp, J.4
  • 34
    • 65449154685 scopus 로고    scopus 로고
    • Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    • 1:CAS:528:DC%2BD1MXkslSqu7w%3D 19173277 10.1002/hep.22749
    • Ura S, Honda M, Yamashita T, Ueda T, Takatori H, Nishino R, Sunakozaka H, Sakai Y, Horimoto K, Kaneko S (2009) Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology 49(4):1098-1112
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1098-1112
    • Ura, S.1    Honda, M.2    Yamashita, T.3    Ueda, T.4    Takatori, H.5    Nishino, R.6    Sunakozaka, H.7    Sakai, Y.8    Horimoto, K.9    Kaneko, S.10
  • 35
    • 42249089850 scopus 로고    scopus 로고
    • MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma
    • 1:CAS:528:DC%2BD1cXkslOjs7s%3D 18307259 10.1002/hep.22158
    • Varnholt H, Drebber U, Schulze F, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M (2008) MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 47(4):1223-1232
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1223-1232
    • Varnholt, H.1    Drebber, U.2    Schulze, F.3    Wedemeyer, I.4    Schirmacher, P.5    Dienes, H.P.6    Odenthal, M.7
  • 36
    • 0031845303 scopus 로고    scopus 로고
    • Inhibitory effect of glycyrrhizin on NF-κB binding activity in CC14-plus ethanol-induced liver cirrhosis in rats
    • 1:CAS:528:DyaK1MXjvVKgt7k%3D 10.1111/j.1600-0676.1998.tb00147.x
    • Wang JY, Guo JS, Li H, Liu SL, Zern MA (1998) Inhibitory effect of glycyrrhizin on NF-κB binding activity in CC14-plus ethanol-induced liver cirrhosis in rats. Liver Int 18(3):180-185
    • (1998) Liver Int , vol.18 , Issue.3 , pp. 180-185
    • Wang, J.Y.1    Guo, J.S.2    Li, H.3    Liu, S.L.4    Zern, M.A.5
  • 37
    • 77950602604 scopus 로고    scopus 로고
    • Effects of MicroRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    • 1:CAS:528:DC%2BC3cXks1Sqsro%3D 20041405
    • Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM (2010) Effects of MicroRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 51(3):836-845
    • (2010) Hepatology , vol.51 , Issue.3 , pp. 836-845
    • Xiong, Y.1    Fang, J.H.2    Yun, J.P.3    Yang, J.4    Zhang, Y.5    Jia, W.H.6    Zhuang, S.M.7
  • 38
    • 36549011761 scopus 로고    scopus 로고
    • Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
    • 1:CAS:528:DC%2BD2sXhsVSmu7jL 2196213 18022723 10.1016/j.jhep.2007.07.032
    • Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM (2008) Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol 48(1):98-106
    • (2008) J Hepatol , vol.48 , Issue.1 , pp. 98-106
    • Yang, L.1    Wang, Y.2    Mao, H.3    Fleig, S.4    Omenetti, A.5    Brown, K.D.6    Sicklick, J.K.7    Li, Y.X.8    Diehl, A.M.9


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