Recombinant fusion protein of albumin-retinol binding protein inactivates stellate cells

Biochemical and Biophysical Research Communications

Volumn 418, Issue 1, 2012, Pages 191-197

  Choi, Soyoung ^a   Park, Sangeun ^a   Kim, Suhyun ^a   Lim, Chaeseung ^b   Kim, Jungho ^c   Cha, Dae Ryong ^d   Oh, Junseo ^a  

^a Korea University College of Medicine   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Sogang University   (South Korea)

^d Korea University College of Medicine   (South Korea)

Author keywords

Albumins; Anti fibrotic drug; Fibrosis; Pancreatic stellate cells; Retinol binding protein

Indexed keywords

ALBUMIN; ANTIFIBROTIC AGENT; HYBRID PROTEIN; RECOMBINANT PROTEIN; RETINOL BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL LYSATE; CONTROLLED STUDY; ENDOCYTOSIS; FIBROSIS; INTERNALIZATION; ITO CELL; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN TRANSPORT; RAT; STELLATE CELL; TISSUE DISTRIBUTION;

ALBUMINS; ANIMALS; CELL LINE; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYSTIC FIBROSIS; FATS; HUMANS; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED BALB C; PANCREATIC STELLATE CELLS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; RETINOL-BINDING PROTEINS; TRANSFECTION;

EID: 84862798586     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.012     Document Type: Article

References (31)

1. Apte M.V., Wilson J.S. Mechanisms of pancreatic fibrosis. Dig. Dis. 2004, 22:273-279.
2. Friedman S.L. Hepatic stellate cells: protean, multifunctional and enigmatic cells of the liver. Physiol. Rev. 2008, 88:125-172.
3. Buchholz M., Kestler H.A., Holzmann K., Ellenrieder V., Schneiderhan W., Siech M., Adler G., Bachem M.G., Gress T.M. Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype. J. Mol. Med. (Berl.) 2005, 83:795-805.
4. Erkan M., Weis N., Pan Z., Schwager C., Samkharadze T., Jiang X., Wirkner U., Giese N.A., Ansorge W., Debus J., Huber P.E., Friess H., Abdollahi A., Kleeff J. Organ - inflammation - and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. Mol. Cancer 2010, 9:88.
5. Bachem M.G., Schneider E., Gross H., Weidenbach H., Schmid R.M., Menke A., Siech M., Beger H., Grunert A., Adler G. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998, 115:421-432.
6. Apte M.V., Haber P.S., Applegate T.L., Norton I.D., McCaughan G.W., Korsten M.A., Pirola R.C., Wilson J.S. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998, 43:128-133.
7. Sporn M.B., Roberts A.B., Goodman D.S. The Retinoids: Biology, Chemistry, and Medicine 1994, Raven Press, New York.
8. Newcomer M.E., Ong D.E. Plasma retinol binding prote: Structure and function of the prototypic lipocalin. Biochim. Biophys. Acta 2000, 1482:57-64.
9. Kawaguchi R., Yu J., Honda J., Hu J., Whitelegge J., Ping P., Wiita P., Bok D., Sun H. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 2007, 315:820-825.
10. Senoo H., Yoshikawa K., Morii M., Miura M., Imai K., Mezaki Y. Hepatic stellate cell (vitamin A-storing cell) and its relative-past, present and future. Cell Biol. Int. 2010, 34:1247-1272.
11. Gjoen T., Bjerkelund T., Blomhoff H.K., Norum K.R., Berg T., Blomhoff R. Liver takes up retinol-binding protein from plasma. J. Biol. Chem. 1987, 262:10926-10930.
12. Senoo H., Stang E., Nilsson A., Kindberg G.M., Berg T., Roos N., Norum K.R., Blomhoff R. Internalization of retinol-binding protein in parenchymal and stellate cells of rat liver. J. Lipid Res. 1990, 31:1229-1239.
13. Senoo H., Smeland S., Malaba L., Bjerknes T., Stang E., Roos N., Berg T., Norum K.R., Blomhoff R. Transfer of retinol-binding protein from HepG2 human hepatoma cells to cocultured rat stellate cells. Proc. Natl. Acad. Sci. USA 1993, 90:3616-3620.
14. Evans T.W. Review article: albumin as a drug--biological effects of albumin unrelated to oncotic pressure. Aliment. Pharmacol. Ther. 2002, 16 Suppl 5:6-11.
15. He X.M., Carter D.C. Atomic structure and chemistry of human serum albumin. Nature 1992, 358:209-215.
16. Curry S., Mandelkow H., Brick P., Franks N. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat. Struct. Biol. 1998, 5:827-835.
17. Simard J.R., Zunszain P.A., Ha C.E., Yang J.S., Bhagavan N.V., Petitpas I., Curry S., Hamilton J.A. Locating high-affinity fatty acid-binding sites on albumin by X-ray crystallography and NMR spectroscopy. Proc. Natl. Acad. Sci. USA 2005, 102:17958-17963.
18. Kim N., Yoo W., Lee J., Kim H., Lee H., Kim Y.S., Kim D.U., Oh J. Formation of vitamin A lipid droplets in pancreatic stellate cells requires albumin. Gut 2009, 58:1382-1390.
19. Kim N., Choi S., Lim C., Lee H., Oh J. Albumin mediates PPAR-gamma or C/EBP-alpha-induced phenotypic changes in pancreatic stellate cells. Biochem. Biophys. Res. Commun. 2010, 391:640-644.
20. Oh J., Seo D.W., Diaz T., Wei B., Ward Y., Ray J.M., Morioka Y., Shi S., Kitayama H., Takahashi C., Noda M., Stetler-Stevenson W.G. Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK. Cancer Res. 2004, 64:9062-9069.
21. Koopman R., Schaart G., Hesselink M.K. Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids. Histochem. Cell Biol. 2001, 116:63-68.
22. Kruse M.L., Hildebrand P.B., Timke C., Folsch U.R., Schafer H., Schmidt W.E. Isolation long-term culture and characterization of rat pancreatic fibroblastoid/stellate cells. Pancreas 2001, 23:49-54.
23. Malaba L., Smeland S., Senoo H., Norum K.R., Berg T., Blomhoff R., Kindberg G.M. Retinol-binding protein and asialo-orosomucoid are taken up by different pathways in liver cells. J. Biol. Chem. 1995, 270:15686-15692.
24. Senoo H., Kojima N., Sato M. Vitamin A-storing cells (stellate cells). Vitam. Horm. 2007, 75:131-159.
25. Nagy N.E., Holven K.B., Roos N., Senoo H., Kojima N., Norum K.R., Blomhoff R. Storage of vitamin A in extrahepatic stellate cells in normal rats. J. Lipid Res. 1997, 38:645-658.
26. Meran S., Steadman R. Fibroblasts and myofibroblasts in renal fibrosis. Int. J. Exp. Pathol. 2011, 92:158-167.
27. Talukdar R., Tandon R.K. Pancreatic stellate cells: new target in the treatment of chronic pancreatitis. J. Gastroenterol. Hepatol. 2008, 23:34-41.
28. Li J.T., Liao Z.X., Ping J., Xu D., Wang H. Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J. Gastroenterol. 2008, 43:419-428.
29. Ghiassi-Nejad Z., Friedman S.L. Advances in antifibrotic therapy. Expert. Rev. Gastroenterol. Hepatol. 2008, 2:803-816.
30. I. Grgic, J.S. Duffield, B.D. Humphreys, The origin of interstitial myofibroblasts in chronic kidney disease, Pediatr Nephrol., 2011 [Epub ahead of print].
31. Yoo W., Lee J., Park S., Kim Y.S., Lim C., Yoon E., Hur G., Oh J. Albumin expression is required for adipocyte differentiation of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 2010, 397:170-175.