The effect of topical vancomycin applied to sternotomy incisions on postoperative Serum vancomycin levels

Journal of Cardiac Surgery

Volumn 26, Issue 5, 2011, Pages 461-465

  Lazar, Harold L ^a   Barlam, Tamar ^b   Cabral, Howard ^b  

^a BOSTON MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFAZOLIN; CREATININE; VANCOMYCIN;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CORONARY ARTERY BYPASS GRAFT; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; FOLLOW UP; HEART INFARCTION; HUMAN; INCIDENCE; INCISION; INFECTION; MALE; MORTALITY; NEPHROTOXICITY; POSTOPERATIVE CARE; REOPERATION; STERNOTOMY; STERNUM; SURGICAL TECHNIQUE;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; CARDIAC SURGICAL PROCEDURES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HEART DISEASES; HUMANS; INTRAOPERATIVE CARE; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PREVALENCE; RETROSPECTIVE STUDIES; STERNOTOMY; SURGICAL WOUND INFECTION; TREATMENT OUTCOME; UNITED STATES; VANCOMYCIN;

EID: 80053348128     PISSN: 08860440     EISSN: 15408191     Source Type: Journal    
DOI: 10.1111/j.1540-8191.2011.01300.x     Document Type: Article

References (17)

1. Vandersalm TJ, Okike ON, Pasque MK, et al: Reduction of sternal infection by application of topical vancomycin. J Thorac Cardiovasc Surg 1989; 98: 618-622. (Pubitemid 19248898)
2. Smith TL, Pearson ML, Wilcox KR,: Emergence of vancomycin resistance in methicillin-resistant staphylococcus aureus. N Engl J Med 1999; 340: 493-501. (Pubitemid 29093284)
3. Sym D, Smith C, Meenan G, et al: Fluorescence polarization immunoassay: Can it result in an overestimation of vancomycin in patients not suffering from renal failure? Ther Drug Monit 2001; 23: 441-444. (Pubitemid 32708932)
4. Ely Lilly and Company, Ltd.: Manufacturers of Vancomycin Hydrochloride as Brand Name Vancocin, Kingsclere Road, Basingstoke, Hampshire RG21 6XA, 2002.
5. Loop FD, Lytle BW, Cosgrove DM,: Sternal wound complications after isolated coronary artery bypass grafting: Early and late mortality, morbidity, and cost of care. Ann Surg 1990; 49: 179-187. (Pubitemid 20086692)
6. Fong IW, Baker CB, McKee DC,: The value of prophylactic antibiotics in aorta-coronary bypass operations: A double-blind randomized trial. J Thorac Cardiovasc Surg 1979; 78: 908-913. (Pubitemid 10171615)
7. Lazar HL, Chipkin SR, Fitzgerald CA, et al: Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation 2004; 109: 1497-1502. (Pubitemid 38420177)
8. Halasz NA,: Wound infection and topical antibiotics: The Surgeon's Dilemma. Arch Surg 1977; 119: 1240-1244. (Pubitemid 8218190)
9. Noon GP, Beal AJ Jr,., Jordan GL Jr,., et al: Clinical evaluation of peritoneal irritation with antibiotic solution. Surgery 1967; 62: 73-78.
10. Brockenbrough EC, Moylan JA,: Treatment of contaminated surgical wounds with a topical antibiotic: A double-blind study of 240 patients. Am Surg 1969; 35: 789-792.
11. Mountain JC, Seal PV,: Topical ampicillin in grid-iron appendectomy wounds. Br J Clin Pract 1970; 24: 111-115.
12. Bates T, Down RHL, Houghton MCV, et al: Topical ampicillin in the prevention of wound infection after appendectomy. Br J Surg 1974; 61: 489-492.
13. Friberg O, Svedjeholm R, Soderquist B, et al: Local gentamicin reduces sternal wound infections after cardiac surgery: A randomized controlled trial. Ann Thorac Surg 2005; 79: 153-162.
14. Desmond J, Lobering A, Harle C, et al: Topical vancomycin applied on closure of the sternotomy wound does not prevent high levels of systemic vancomycin. Eur J Cardiothorac Surg 2003; 23: 765-777.
15. El-Oakley RM, Nimer KA, Bukhari E,: Is the use of topical vancomycin to predict mediastinitis after cardiac surgery justified? J Thorac Cardiovasc Surg 2000; 119: 190-191. (Pubitemid 30046341)
16. Sakoulas G, Gold HS, Cohen RA, et al: Effects of prolonged vancomycin administration on methicillin-resistant staphylococcus aureus (MRSA) in a patient with recurrent bacteremia. J Antimicrob Chemother 2006; 57: 699-704.
17. Tsuji B, Rybac MJ, Lau KL, et al: Evaluation of accessory gene regulator (AGR) group and function in the proclivity toward vancomycin intermittent resistance and staphylococcus aureus. J Antimicrob Chemother 2007; 59: 1089-1091. (Pubitemid 46355301)