Noradrenaline and neuropeptide Y contribute to initial, but not sustained, vasodilatation in response to local skin warming in humans

Experimental Physiology

Volumn 99, Issue 2, 2014, Pages 381-392

  Hodges, Gary J ^a   Sparks, Paul A ^a  

^a UNIVERSITY OF ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CLONIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G),N(G) DIMETHYLARGININE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; NITROPRUSSIDE SODIUM; NORADRENALIN; PROPRANOLOL; YOHIMBINE; ARGININE; DRUG DERIVATIVE; N(G) AMINOARGININE; N(G)-AMINOARGININE; NOS3 PROTEIN, HUMAN;

ADRENERGIC RECEPTOR BLOCKING; ADULT; ARTICLE; CONTROLLED STUDY; CUTANEOUS VASCULAR CONDUCTANCE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INFUSION; FOREARM; HEAT; HUMAN; HUMAN EXPERIMENT; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; NORMAL HUMAN; PERFUSION; REDUCTION; SKIN; SKIN CONDUCTANCE; SKIN TEMPERATURE; SKIN WARMING; VASODILATATION; WARMING; YOUNG ADULT; METABOLISM; PHYSIOLOGY; RADIATION EXPOSURE;

ADULT; ARGININE; CLONIDINE; HUMANS; MALE; NEUROPEPTIDE Y; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; NOREPINEPHRINE; PROPRANOLOL; SKIN; SKIN TEMPERATURE; VASODILATION; YOHIMBINE;

EID: 84895071051     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2013.075549     Document Type: Article

References (52)

1. Angus JA, Cocks TM & Satoh K (1986). The alpha adrenoceptors on endothelial cells. Fed Proc 45, 2355-2359.
2. Bradley E, Law A, Bell D & Johnson CD (2003). Effects of varying impulse number on cotransmitter contributions to sympathetic vasoconstriction in rat tail artery. Am J Physiol Heart Circ Physiol 284, H2007-H2014.
3. Carter SJ & Hodges GJ (2011). Sensory and sympathetic nerve contributions to the cutaneous vasodilator response from a noxious heat stimulus. Exp Physiol 96, 1208-1217.
4. Charkoudian N, Stephens DP, Pirkle KC, Kosiba WA & Johnson JM (1999). Influence of female reproductive hormones on local thermal control of skin blood flow. J Appl Physiol 87, 1719-1723.
5. Cocks TM & Angus JA (1983). Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 305, 627-630.
6. Collins AB, Carter SJ, Del Pozzi AT & Hodges GJ (2012). Norepinephrine, but not neuropeptide Y, is involved in the cutaneous vasodilator response in young human females. FASEB J 26, lb751 (Abstract).
7. Crandall CG, Shibasaki M & Yen TC (2002). Evidence that the human cutaneous venoarteriolar response is not mediated by adrenergic mechanisms. J Physiol 538, 599-605.
8. Drummond PD (1999). Nitroprusside inhibits thermal hyperalgesia induced by noradrenaline in capsaicin-treated skin. Pain 80, 405-412.
9. Drummond PD (2009a). Alpha-1 adrenoceptor stimulation triggers axon-reflex vasodilatation in human skin. Auton Neurosci 151, 159-163.
10. 1-Adrenoceptors augment thermal hyperalgesia in mildly burnt skin. Eur J Pain 13, 273-279.
11. Drummond PD (2010). Inflammatory consequences of cutaneous stimulation. Exp Neurol 222, 181-183.
12. Drummond PD (2011). Inflammation contributes to axon reflex vasodilatation evoked by iontophoresis of an alpha-1 adrenoceptor agonist. Auton Neurosci 159, 90-97.
13. Drummond PD & Lipnicki DM (1999). Noradrenaline provokes axon reflex hyperaemia in the skin of the human forearm. J Auton Nerv Syst 77, 39-44.
14. Edvinsson L, Ekblad E, Håkanson R & Wahlestedt C (1984). Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br J Pharmacol 83, 519-525.
15. Ekblad E, Edvinsson L, Wahlestedt C, Uddman R, Håkanson R & Sundler F (1984). Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regul Pept 8, 225-235.
16. Green DJ, Maiorana A, O'Driscoll G & Taylor R (2004). Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol 561, 1-25.
17. Hodges GJ, Chiu C, Kosiba WA, Zhao K & Johnson JM (2009a). The effect of microdialysis needle trauma on cutaneous vascular responses in humans. J Appl Physiol 106, 1112-1118.
18. Hodges GJ, Jackson DN, Mattar L, Johnson JM & Shoemaker JK (2009b). Neuropeptide Y and neurovascular control in skeletal muscle and skin. Am J Physiol Regul Integr Comp Physiol 297, R546-R555.
19. Hodges GJ, Kosiba WA, Zhao K, Alvarez GE & Johnson JM (2007). The role of baseline in the cutaneous vasoconstrictor responses during combined local and whole body cooling in humans. Am J Physiol Heart Circ Physiol 293, H3187-H3192.
20. Hodges GJ, Kosiba WA, Zhao K & Johnson JM (2008). The involvement of norepinephrine, neuropeptide Y, and nitric oxide in the cutaneous vasodilator response to local heating in humans. J Appl Physiol 105, 233-240.
21. Hodges GJ, Kosiba WA, Zhao K & Johnson JM (2009c). The involvement of heating rate and vasoconstrictor nerves in the cutaneous vasodilator response to skin warming. Am J Physiol Heart Circ Physiol 296, H51-H56.
22. Hodges GJ & Sparks PA (2013). Contributions of endothelial nitric oxide synthase, noradrenaline, and neuropeptide Y to local warming-induced cutaneous vasodilatation in men. Microvasc Res.
23. Hodges GJ, Zhao K, Kosiba WA & Johnson JM (2006). The involvement of nitric oxide in the cutaneous vasoconstrictor response to local cooling in humans. J Physiol 574, 849-857.
24. Houghton BL, Meendering JR, Wong BJ & Minson CT (2006). Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin. J Physiol 572, 811-820.
25. 1-receptor activation in the hindlimb of Sprague-Dawley rats. J Physiol 562, 285-294.
26. Johnson JM, ed. (1990). The cutaneous circulation. In Laser-Doppler Blood Flowmetry, ed. Shepherd AP & Öberg PA, pp. 121-139.
27. Johnson JM & Proppe DW (1996). Cardiovascular adjustments to heat stress. In Handbook of Physiology, section 4, Environmental Physiology, ed. Fregly MJ & Blatteis CM, pp. 215-243. American Physiological Society, Bethesda, MD.
28. Johnson JM, Yen TC, Zhao K & Kosiba WA (2005). Sympathetic, sensory, and nonneuronal contributions to the cutaneous vasoconstrictor response to local cooling. Am J Physiol Heart Circ Physiol 288, H1573-H1579.
29. Kellogg DL Jr, Liu Y, Kosiba IF & O'Donnell D (1999). Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol 86, 1185-1190.
30. Kellogg DL Jr, Zhao JL, Coey U & Green JV (2005). Acetylcholine-induced vasodilation is mediated by nitric oxide and prostaglandins in human skin. J Appl Physiol 98, 629-632.
31. Kellogg DL Jr, Zhao JL & Wu Y (2008a). Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. Am J Physiol Heart Circ Physiol 295, H123-H129.
32. Kellogg DL Jr, Zhao JL & Wu Y (2008b). Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. J Physiol 586, 847-857.
33. Kellogg DL Jr, Zhao JL & Wu Y (2009). Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans. J Appl Physiol 107, 1438-1444.
34. Kellogg DL Jr, Zhao JL, Wu Y & Johnson JM (2011). Antagonism of soluble guanylyl cyclase attenuates cutaneous vasodilation during whole body heat stress and local warming in humans. J Appl Physiol 110, 1406-1413.
35. 1-adrenergic venoconstriction in vivo. Hypertension 28, 483-487.
36. Maruo K, Yamamoto H, Yamamoto S, Nagata T, Fujikawa H, Kanno T, Yaguchi T, Maruo S, Yoshiya S & Nishizaki T (2006). Modulation of P2X receptors via adrenergic pathways in rat dorsal root ganglion neurons after sciatic nerve injury. Pain 120, 106-112.
37. Minson CT, Berry LT & Joyner MJ (2001). Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol 91, 1619-1626.
38. Minson CT, Holowatz LA, Wong BJ, Kenney WL & Wilkins BW (2002). Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating. J Appl Physiol 93, 1644-1649.
39. Mosley JG (1969). A reduction in some vasodilator responses in free-standing man. Cardiovasc Res 3, 14-21.
40. 2+ signals to oppose vasoconstriction of mouse mesenteric arteries. Am J Physiol Heart Circ Physiol 302, H594-H602.
41. Nilsson T, Lind H, Brunkvall J & Edvinsson L (2000). Vasodilation in human subcutaneous arteries induced by neuropeptide Y is mediated by neuropeptide Y Y1 receptors and is nitric oxide dependent. Can J Physiol Pharmacol 78, 251-255.
42. Öberg PA (1990). Laser-Doppler flowmetry. Crit Rev Biomed Eng 18, 125-163.
43. Saumet JL, Kellogg DL Jr, Taylor WF & Johnson JM (1988). Cutaneous laser-Doppler flowmetry: influence of underlying muscle blood flow. J Appl Physiol 65, 478-481.
44. Stephens DP, Aoki K, Kosiba WA & Johnson JM (2001). Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol 280, H1496-H1504.
45. Stephens DP, Saad AR, Bennett LA, Kosiba WA & Johnson JM (2004). Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans. Am J Physiol Heart Circ Physiol 287, H1404-H1409.
46. Tew GA, Klonizakis M, Moss J, Ruddock AD, Saxton JM & Hodges GJ (2011a). Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Exp Physiol 96, 163-170.
47. Tew GA, Saxton JM, Klonizakis M, Moss J, Ruddock AD & Hodges GJ (2011b). Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. J Appl Physiol 110, 1264-1270.
48. Thompson-Torgerson CS, Holowatz LA, Flavahan NA & Kenney WL (2007). Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin. Am J Physiol Heart Circ Physiol 292, H1700-H1705.
49. Trevisani M, Campi B, Gatti R, André E, Materazzi S, Nicoletti P, Gazzieri D & Geppetti P (2007). The influence of alpha1-adrenoreceptors on neuropeptide release from primary sensory neurons of the lower urinary tract. Eur Urol 52, 901-908.
50. Vanhoutte PM & Miller VM (1989). Alpha 2-adrenoceptors and endothelium-derived relaxing factor. Am J Med 87, 1S-5S.
51. Wong BJ & Fieger SM (2010). Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans. J Physiol 588, 4317-4326.
52. Xie J, Park SK, Chung K & Chung JM (2001). The effect of lumbar sympathectomy in the spinal nerve ligation model of neuropathic pain. J Pain 2, 270-278.