Effects of multivitamin supplement on cataract and age-related macular degeneration in a randomized trial of male physicians

Ophthalmology

Volumn 121, Issue 2, 2014, Pages 525-534

  Christen, William G ^a   Glynn, Robert J ^a,d   Manson, Joann E ^a,d   Macfadyen, Jean ^a   Bubes, Vadim ^a   Schvartz, Miriam ^a   Buring, Julie E ^a,c,d   Sesso, Howard D ^a,d   Gaziano, J Michael ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VA BOSTON HEALTHCARE SYSTEM   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; MULTIVITAMIN; PLACEBO;

ADULT; AGE RELATED MACULAR DEGENERATION; AGED; ARTICLE; CATARACT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEN'S HEALTH; MIDDLE AGED; PHYSICIAN; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; UNITED STATES; VISUAL ACUITY; VITAMIN SUPPLEMENTATION;

AGED; CATARACT; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MACULAR DEGENERATION; MALE; MIDDLE AGED; PHYSICIANS; QUESTIONNAIRES; RISK FACTORS; TREATMENT OUTCOME; UNITED STATES; VISUAL ACUITY; VITAMINS;

EID: 84895069935     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2013.09.038     Document Type: Article

References (57)

1. N.G. Congdon, and K.P. West Jr. Nutrition and the eye Curr Opin Ophthalmol 10 1999 464 473
2. C.J. Chiu, and A. Taylor Nutritional antioxidants and age-related cataract and maculopathy Exp Eye Res 84 2007 229 245
3. V. Agte, and K. Tarwadi The importance of nutrition in the prevention of ocular disease with special reference to cataract Ophthalmic Res 44 2010 166 172
4. A.E. Fletcher Free radicals, antioxidants and eye diseases: evidence from epidemiological studies on cataract and age-related macular degeneration Ophthalmic Res 44 2010 191 198
5. N. Krishnadev, A.D. Meleth, and E.Y. Chew Nutritional supplements for age-related macular degeneration Curr Opin Ophthalmol 21 2010 184 189
6. J.M. Seddon Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract Am J Clin Nutr 85 2007 304S 307S
7. Y.H. Cui, C.X. Jing, and H.W. Pan Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies Am J Clin Nutr 98 2013 778 786
8. H. Gerster Antioxidant vitamins in cataract prevention Z Ernahrungswiss 28 1989 56 75
9. A. Taylor Role of nutrients in delaying cataracts Ann N Y Acad Sci 669 1992 111 124
10. D.T. Organisciak, H.M. Wang, Z.Y. Li, and M.O. Tso The protective effect of ascorbate in retinal light damage of rats Invest Ophthalmol Vis Sci 26 1985 1580 1588
11. W.T. Ham Jr., H.A. Mueller, and J.J. Ruffolo Jr. et al. Basic mechanisms underlying the production of photochemical lesions in the mammalian retina Curr Eye Res 3 1984 165 174
12. M.O. Tso Experiments on visual cells by nature and man: in search of treatment for photoreceptor degeneration. Friedenwald lecture Invest Ophthalmol Vis Sci 30 1989 2430 2454
13. J.M. Teikari, M. Rautalahti, and J. Haukka et al. Incidence of cataract operations in Finnish male smokers unaffected by alpha tocopherol or beta carotene supplements J Epidemiol Community Health 52 1998 468 472
14. Age-Related Eye Disease Study Research Group A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9 Arch Ophthalmol 119 2001 1439 1452
15. REACT Group, L.T. Chylack Jr., N.P. Brown, and A. Bron et al. The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract Ophthalmic Epidemiol 9 2002 49 80
16. J.J. McNeil, L. Robman, and G. Tikellis et al. Vitamin E supplementation and cataract: randomized controlled trial Ophthalmology 111 2004 75 84
17. W.G. Christen, R.J. Glynn, E.Y. Chew, and J.E. Buring Vitamin E and age-related cataract in a randomized trial of women Ophthalmology 115 2008 822 829
18. W.G. Christen, R.J. Glynn, and H.D. Sesso et al. Age-related cataract in a randomized trial of vitamins E and C in men Arch Ophthalmol 128 2010 1397 1405
19. W. Christen, R. Glynn, and R. Sperduto et al. Age-related cataract in a randomized trial of beta-carotene in women Ophthalmic Epidemiol 11 2004 401 412
20. W.G. Christen, J.E. Manson, and R.J. Glynn et al. A randomized trial of beta carotene and age-related cataract in US physicians Arch Ophthalmol 121 2003 372 378
21. D.C. Gritz, M. Srinivasan, and S.D. Smith et al. The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India Br J Ophthalmol 90 2006 847 851
22. R.D. Sperduto, T.S. Hu, and R.C. Milton et al. The Linxian cataract studies. Two nutrition intervention trials Arch Ophthalmol 111 1993 1246 1253
23. Clinical Trial of Nutritional Supplements and Age-Related Cataract Study Group A randomized, double-masked, placebo-controlled clinical trial of multivitamin supplementation for age-related lens opacities: Clinical Trial of Nutritional Supplements and Age-Related Cataract report no. 3 Ophthalmology 115 2008 599 607
24. Age-Related Eye Disease Study Research Group A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8 Arch Ophthalmol 119 2001 1417 1436
25. W.G. Christen, R.J. Glynn, and E.Y. Chew et al. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study Arch Intern Med 169 2009 335 341
26. J.M. Teikari, L. Laatikainen, and J. Virtamo et al. Six-year supplementation with alpha-tocopherol and beta-carotene and age-related maculopathy Acta Ophthalmol Scand 76 1998 224 229
27. H.R. Taylor, G. Tikellis, and L.D. Robman et al. Vitamin E supplementation and macular degeneration: randomised controlled trial BMJ 325 2002 11
28. W.G. Christen, R.J. Glynn, E.Y. Chew, and J.E. Buring Vitamin E and age-related macular degeneration in a randomized trial of women Ophthalmology 117 2010 1163 1168
29. W.G. Christen, J.E. Manson, and R.J. Glynn et al. Beta carotene supplementation and age-related maculopathy in a randomized trial of US physicians Arch Ophthalmol 125 2007 333 339
30. W.G. Christen, R.J. Glynn, and H.D. Sesso et al. Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians Ophthalmology 119 2012 1642 1649
31. W.G. Christen, J.M. Gaziano, and C.H. Hennekens Design of Physicians' Health Study II-a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials Ann Epidemiol 10 2000 125 134
32. J.M. Gaziano, R.J. Glynn, and W.G. Christen et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial JAMA 301 2009 52 62
33. H.D. Sesso, J.E. Buring, and W.G. Christen et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial JAMA 300 2008 2123 2133
34. C.H. Hennekens, J.E. Buring, and J.E. Manson et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease N Engl J Med 334 1996 1145 1149
35. Steering Committee of the Physicians' Health Study Research Group Final report on the aspirin component of the ongoing Physicians' Health Study N Engl J Med 321 1989 129 135
36. F. Ederer Shall we count numbers of eyes or numbers of subjects? Arch Ophthalmol 89 1973 1 2
37. R.J. Glynn, and B. Rosner Accounting for the correlation between fellow eyes in regression analysis Arch Ophthalmol 110 1992 381 387
38. Eye Diseases Prevalence Research Group Prevalence of cataract and pseudophakia/aphakia among adults in the United States Arch Ophthalmol 122 2004 487 494
39. National Eye Institute. National Plan for Eye and Vision Research: Lens and Cataract Program. Available at: http://www.nei.nih.gov/strategicplanning/np- lens.asp. Accessed September 15, 2013.
40. Age-Related Eye Disease Study Research Group Centrum use and progression of age-related cataract in the Age-Related Eye Disease Study: a propensity score approach. AREDS report no. 21 Ophthalmology 113 2006 1264 1270
41. L. Chasan-Taber, W.C. Willett, and J.M. Seddon et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women Am J Clin Nutr 70 1999 509 516
42. S.M. Moeller, R. Voland, and L. Tinker et al. CAREDS Study Group. Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative Arch Ophthalmol 126 2008 354 364
43. J.A. Mares-Perlman, W.E. Brady, and B.E. Klein et al. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities Invest Ophthalmol Vis Sci 36 1995 276 288
44. L. Brown, E.B. Rimm, and J.M. Seddon et al. A prospective study of carotenoid intake and risk of cataract extraction in US men Am J Clin Nutr 70 1999 517 524
45. H.T. Vu, L. Robman, and A. Hodge et al. Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project Invest Ophthalmol Vis Sci 47 2006 3783 3786
46. B.J. Lyle, J.A. Mares-Perlman, and B.E. Klein et al. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study Am J Epidemiol 149 1999 801 809
47. W.G. Christen, S. Liu, and R.J. Glynn et al. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study Arch Ophthalmol 126 2008 102 109
48. R.A. Bone, J.T. Landrum, and S.T. Mayne et al. Macular pigment in donor eyes with and without AMD: a case-control study Invest Ophthalmol Vis Sci 42 2001 235 240
49. S.M. Moeller, N. Parekh, L. Tinker CAREDS Research Study Group Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative Arch Ophthalmol 124 2006 1151 1162
50. B. Olmedilla, F. Granado, I. Blanco, and M. Vaquero Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study Nutrition 19 2003 21 24
51. C. Arnold, L. Winter, and K. Frohlich et al. Macular xanthophylls and omega-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial JAMA Ophthalmol 131 2013 564 572
52. S. Piermarocchi, S. Saviano, V. Parisi CARMIS Study Group Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study Eur J Ophthalmol 22 2012 216 225
53. L. Ma, S.F. Yan, and Y.M. Huang et al. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration Ophthalmology 119 2012 2290 2297
54. S. Beatty, U. Chakravarthy, and J.M. Nolan et al. Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration Ophthalmology 120 2013 600 606
55. E.J. Berrow, H.E. Bartlett, F. Eperjesi, and J.M. Gibson The effects of a lutein-based supplement on objective and subjective measures of retinal and visual function in eyes with age-related maculopathy-a randomised controlled trial Br J Nutr 109 2013 2008 2014
56. Age-Related Eye Disease Study 2 (AREDS2) Research Group, E.Y. Chew, J.P. SanGiovanni, and F.L. Ferris et al. Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4 JAMA Ophthalmol 131 2013 843 850
57. Age-Related Eye Disease Study 2 Research Group Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial JAMA 309 2013 2005 2015