Re "Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions" [Sieck, J.B., Cordes, T., Budach, W.E., Rhiel, M.H., Suemeghy, Z., Leist, C., Villiger, T.K., Morbidelli, M., Soos, M., 2013. Journal of Biotechnology 164, 41-49]

Journal of Biotechnology

Volumn 171, Issue 1, 2014, Pages 82-84

  Nienow, Alvin W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BIOENGINEERING; BIOREACTORS; BIOTECHNOLOGY; MODELS, THEORETICAL;

EID: 84895067099     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2013.12.002     Document Type: Letter

References (26)

1. Baldyga J., Bourne J.R. Some consequences for turbulent mixing of fine scale intermittency. Chemical Engineering Science 1992, 47:3943-3958.
2. Cutter L.A. Flow and turbulence in stirred tanks. AIChE Journal 1966, 12:35-44.
3. Delafosse A., Collignon M.L., Crine M., Toye D. Estimation of the turbulent kinetic energy dissipation rate from 2D-PIV measurements in a vessel stirred by an axial Mixel TTP impeller. Chemical Engineering Science 2011, 66:1728-1737.
4. Enfors S.O., Jahic M., Rozkov A., Xu B., Hecker M., Jurgen B., Kruger E., Schweder T., Hamer G., O'Beirne D., Noisommit-Rizzi N., Reuss M., et al. Physiological responses to mixing in large bioreactors. Journal of Biotechnology 2001, 85:175-185.
5. Gabriele A., Nienow A.W., Simmons M.J.H. Use of angle resolved PIV to estimate local specific energy dissipation rates for up-and down-pumping pitched blade agitators in a stirred tank. Chemical Engineering Science 2009, 64:126-143.
6. Geisler R., Krebs R., Forschner P. Local turbulent shear stress in stirred vessels and its significance for different mixing tasks. Proceedings of 8th European Mixing Conference 1994, 241-251. Institution of Chemical Engineers, Rugby, UK.
7. GodoySilva R., Mollet M., Chalmers J.J. Evaluation of the effect of chronic hydrodynamical stresses on cultures of suspended CHO-6E6 cells. Biotechnology and Bioengineering 2009, 102:1109-1130.
8. GodoySilva R., Chalmers J.J., Casnocha S.A., Bass L.A., Ma N. Physiological responses of CHO cells to repetitive hydrodynamic stress. Biotechnology and Bioengineering 2009, 103:1103-1117.
9. Guida A., Nienow A.W., Barigou M. Lagrangian tools for the analysis of mixing in single- and multi-phase flow systems. AIChE Journal 2012, 58:31-45.
10. Hewitt C.J., Nienow A.W. The scale-up of microbial batch and fed-batch fermentation processes. Advances in Applied Microbiology 2007, 62:105-136.
11. Hu W., Berdugo C., Chalmers J.J. The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding. Cytotechnology 2011, 63:445-460.
12. Kresta S.M., Brodkey R.S. Turbulence in mixing applications. Handbook of Industrial Mixing 2004, 507-539. Wiley-Interscience, New York, (Chapter 9). E.L. Paul, V.A. Atiemo-Obeng, S.M. Kresta (Eds.).
13. Larrson G., Enfors S.-O. Studies of insufficient mixing in bioreactors: effects of limiting oxygen concentration and short term oxygen starvation on Penicillium chrysogenum. Bioprocess Engineering 1988, 3:123-127.
14. Marshall E.M., Bakker A. Computational fluid mixing. Handbook of Industrial Mixing 2004, 257-343. Wiley-Interscience, New York, (Chapter 5). E.L. Paul, V.A. Atiemo-Obeng, S.M. Kresta (Eds.).
15. Nienow A.W. Hydrodynamics of stirred bioreactors. Applied Mechanics Reviews 1998, 51:3-32.
16. Nienow A.W. Reactor engineering in large scale animal cell culture. Cytotechnology 2006, 50:9-33.
17. Nienow A.W. Scale-up, stirred tank reactors. Encyclopedia of Industrial Biotechnology 2010, vol. 7:4328-4341. John Wiley & Sons, Inc., Hoboken, NJ, USA.
18. Nienow A.W., Scott W.H., Hewitt C.J., Thomas C.R., Lewis G., Amanullah A., Kiss R., Meier S.J. Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture. Chemical Engineering Research and Design 2013, 91:2265-2274.
19. Nienow A.W., Rielly C.D., Brosnan K.M., Bargh N., Lee K., Coopman K., Hewitt C.J. The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4. Biochemical Engineering Journal 2013, 76:25-36.
20. Oosterhuis N.M.G., Kossen N.W.F., Olivier N.P.C., Schenk E.S. Scale-down and optimization studies of the gluconic acid fermentation by Gluconobacter oxydans. Biotechnology and Bioengineering 1985, 27:63-73.
21. Osman J.J., Birch J., Varley J. The response of GS-NSO myeloma cells to single and multiple pH perturbations. Biotechnology and Bioengineering 2002, 79:398-407.
22. Sieck J.B., Cordes T., Budach W.E., Rhiel M.H., Suemeghy Z., Leist C., Villiger T.K., Morbidelli M., Soos M. Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions. Journal of Biotechnology 2013, 164:41-49.
23. Tanzeglock T., Soos M., Stephanopoulos G., Morbidelli M. Induction of mammalian cell death by simple shear and extensional flows. Biotechnology and Bioengineering 2009, 104:360-370.
24. Wernersson E.S., Tragardh C. Scale-up of Rushton turbine-agitated tanks. Chemical Engineering Science 1999, 54:4245-4256.
25. Zhou G., Kresta S.M. Impact of geometry on the maximum turbulence energy dissipation rate for various impellers. AIChE Journal 1996, 42:2476-2490.
26. Zhu H., Bujalski W., Simmons M.J.H., Nienow A.W. Mixing studies in a model aerated bioreactor equipped with an up- or a down-pumping 'elephant ear' agitator; power, hold-up and aerated flow field measurements. Chemical Engineering Research and Design 2009, 87:307-317.