The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4

Biochemical Engineering Journal

Volumn 76, Issue , 2013, Pages 25-36

  Nienow, Alvin W ^a,b   Rielly, Christopher D ^a   Brosnan, Kathryn ^a   Bargh, Neil ^c   Lee, Kenneth ^a   Coopman, Karen ^a   Hewitt, Christopher J ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c SARTORIUS STEDIM BIOTECH GMBH   (Germany)

Author keywords

Ambr microscale bioreactor; CFD; CHO cell culture; Mass transfer; Specific power input; Transitional flow

Indexed keywords

BIOLOGICAL PERFORMANCE; CHO CELL CULTURES; MICROSCALE BIOREACTORS; PHYSICAL CHARACTERISATION; PHYSICAL CHARACTERISTICS; SPECIFIC POWER INPUTS; SUPERFICIAL GAS VELOCITIES; TRANSITIONAL FLOW;

BIOCONVERSION; BOTTLES; CELL CULTURE; COMPUTATIONAL FLUID DYNAMICS; MASS TRANSFER; SECONDARY BATTERIES;

BIOREACTORS;

IMMUNOGLOBULIN G4; OXYGEN;

AIR; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOREACTOR; CELL GROWTH; CHO CELL; CONTROLLED STUDY; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PRODUCTIVITY; VELOCITY;

EID: 84877337442     PISSN: 1369703X     EISSN: 1873295X     Source Type: Journal    
DOI: 10.1016/j.bej.2013.04.011     Document Type: Article

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