Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 2, 2014, Pages

  Álvarez Twose, Iván ^a,b   Zanotti, Roberta ^c,d   González De Olano, David ^b,e   Bonadonna, Patrizia ^d,f   Vega, Arantza ^g   Matito, Almudena ^a,b   Sánchez Muñoz, Laura ^a,b   Morgado, José Mário ^a,b   Perbellini, Omar ^c,d   García Montero, Andrés ^b,h   De Matteis, Giovanna ^d,f   Teodósio, Cristina ^b,h   Rossini, Maurizio ^d,f   Jara Acevedo, María ^b,h   Schena, Donatella ^d,f   Mayado, Andrea ^b,h   Zamò, Alberto ^d,f   Mollejo, Manuela ^a,b   Sánchez López, Paula ^a   Cabañes, Nieves ^a   Orfao, Alberto ^b,h   Escribano, Luis ^b   more..

^a HOSPITAL VIRGEN DE LA SALUD   (Spain)

^b Spanish Network on Mastocytosis ^*  (Spain)

^c UNIVERSITY OF VERONA   (Italy)

^d Multidisciplinary Outpatients Clinics for Mastocytosis   (Italy)

^e HOSPITAL UNIVERSITARIO DE FUENLABRADA   (Spain)

^f UNIVERSITY HOSPITAL OF VERONA   (Italy)

^g HOSPITAL UNIVERSITARIO DE GUADALAJARA   (Spain)

^h Centro de Investigacion del Cancer   (Spain)

Author keywords

anaphylaxis; Hymenoptera; insect; insect sting anaphylaxis; Mast cell; mastocytosis

Indexed keywords

TRYPTASE;

ADULT; AGED; ANAPHYLAXIS; ARTICLE; CLINICAL FEATURE; FEMALE; GENE MUTATION; HUMAN; INSECT ALLERGY; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; ONCOGENE C KIT; PRIORITY JOURNAL; SCORING SYSTEM; SEX DIFFERENCE; SYSTEMIC MASTOCYTOSIS;

ANAPHYLAXIS; BM; BONE MARROW; CLMAST; HYMENOPTERA; INDOLENT SYSTEMIC MASTOCYTOSIS; INDOLENT SYSTEMIC MASTOCYTOSIS WITH SKIN LESIONS; INDOLENT SYSTEMIC MASTOCYTOSIS WITHOUT SKIN LESIONS; INSECT; INSECT STING ANAPHYLAXIS; INSTITUTO DE ESTUDIOS DE MASTOCITOSIS DE CASTILLA LA MANCHA, THE CLINICAL REFERENCE CENTRE OF THE SPANISH NETWORK ON MASTOCYTOSIS (REMA); ISM; ISMS(+); ISMS(-); MAST CELL; MAST CELL ACTIVATION SYNDROME; MASTOCYTOSIS; MC; MCAS; REMA; SBT; SERUM BASELINE TRYPTASE; SM; SPANISH NETWORK ON MASTOCYTOSIS; SYSTEMIC MASTOCYTOSIS; VENOM IMMUNOTHERAPY; VIT; WHO; WORLD HEALTH ORGANIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLERGENS; ANAPHYLAXIS; ANIMALS; BEES; FEMALE; HUMANS; IMMUNOGLOBULIN E; INSECT BITES AND STINGS; MALE; MASTOCYTOSIS, SYSTEMIC; MIDDLE AGED; SKIN DISEASES; SKIN TESTS; TRYPTASES; WASPS; YOUNG ADULT;

EID: 84895061744     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.06.020     Document Type: Article

References (50)

1. H. Nagata, A.S. Worobec, C.K. Oh, B.A. Chowdhury, S. Tannenbaum, and Y. Suzuki et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder Proc Natl Acad Sci U S A 92 1995 10560 10564
2. B.J. Longley, L. Tyrrell, S.Z. Lu, Y.S. Ma, K. Langley, and T.G. Ding et al. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm Nature Genet 12 1996 312 314
3. B.J. Longley Jr., D.D. Metcalfe, M. Tharp, X.M. Wang, L. Tyrrell, and S.Z. Lu et al. Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis Proc Natl Acad Sci U S A 96 1999 1609 1614
4. A.S. Yavuz, P.E. Lipsky, S. Yavuz, D.D. Metcalfe, and C. Akin Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene Blood 100 2002 661 665
5. A. Pardanani, T. Reeder, C.Y. Li, and A. Tefferi Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia Leuk Res 27 2003 883 885
6. A.C. Garcia-Montero, M. Jara-Acevedo, C. Teodosio, M.L. Sanchez, R. Nunez, and A. Prados et al. KIT mutation in mast cells and other bone marrow haematopoietic cell lineages in systemic mast cell disorders. A prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients Blood 108 2006 2366 2372
7. P. Valent, W.R. Sperr, L.B. Schwartz, and H.P. Horny Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hernatopoietic neoplasms J Allergy Clin Immunol 114 2004 3 11
8. P. Valent, C. Akin, L. Escribano, M. Fodinger, K. Hartmann, and K. Brockow et al. Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria Eur J Clin Invest 37 2007 435 453
9. I. Alvarez-Twose, O.D. Gonzalez de, L. Sanchez-Munoz, C. Teodosio, M. Jara-Acevedo, and I. Sanchez-Matas et al. Clinical, biological and molecular characteristics of mast cell activation disorders: a prospective study in 62 patients by the Spanish Network on Mastocytosis (REMA) J Allergy Clin Immunol 123 2009 S141
10. P. Bonadonna, O. Perbellini, G. Passalacqua, B. Caruso, S. Colarossi, and F.D. Dal et al. Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels J Allergy Clin Immunol 123 2009 680 686
11. R. Zanotti, P. Bonadonna, M. Bonifacio, A. Artuso, D. Schena, and M. Rossini et al. Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis Haematologica 96 2011 482 484
12. L. Sanchez-Munoz, I. Alvarez-Twose, A.C. Garcia-Montero, C. Teodosio, M. Jara-Acevedo, and C.E. Pedreira et al. Evaluation of the WHO criteria for the classification of patients with mastocytosis Mod Pathol 24 2011 1157 1168
13. I. Alvarez-Twose, J.M. Morgado, L. Sanchez-Munoz, A. Garcia-Montero, M. Mollejo, and A. Orfao et al. Current state of biology and diagnosis of clonal mast cell diseases in adults Int J Lab Hematol 34 2012 445 460
14. I. Alvarez-Twose, D. Gonzalez de Olano, L. Sanchez-Munoz, A. Matito, M.I. Esteban-Lopez, and A. Vega et al. Clinical, biological and molecular characteristics of systemic mast cell disorders presenting with severe mediator-related symptoms J Allergy Clin Immunol 125 2010 1269 1278
15. I. Alvarez-Twose, D. Gonzalez-de-Olano, L. Sanchez-Munoz, A. Matito, M. Jara-Acevedo, and C. Teodosio et al. Validation of the REMA score for predicting mast cell clonality and systemic mastocytosis in patients with systemic mast cell activation symptoms Int Arch Allergy Immunol 157 2011 275 280
16. H.P. Horny, D.D. Metcalfe, J.M. Bennet, B.J. Bain, C. Akin, and L. Escribano et al. Mastocytosis S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 2008 IARC Lyon, France 54 63
17. Position paper: allergen standardization and skin tests. The European Academy of Allergology and Clinical Immunology Allergy 48 1993 48 82
18. R.I. Monsalve, A. Vega, L. Marques, A. Miranda, J. Fernandez, and V. Soriano et al. Component-resolved diagnosis of vespid venom-allergic individuals: phospholipases and antigen 5s are necessary to identify Vespula or Polistes sensitization Allergy 67 2012 528 536
19. L. Escribano, A. Garcia-Montero, L. Sanchez-Munoz, C. Teodosio, I. Alvarez-Twose, and M. Jara-Acevedo et al. Diagnosis of adult mastocytosis: role for bone marrow analysis K. Kottke-Marchant, B. Davis, Laboratory Hematology Practice 2012 Wiley-Blackwell London, UK 388 398
20. W. Sperr, L. Escribano, J.H. Jordan, G.H. Schernthaner, M. Kundi, and H.P. Horny et al. Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis Leuk Res 25 2001 529 536
21. H.P. Horny, C. Sillaber, D. Menke, E. Kaiserling, M. Wehrmann, and B. Stehberger et al. Diagnostic value of immunostaining for tryptase in patients with mastocytosis Am J Surg Pathol 22 1998 1132 1140
22. H.P. Horny, and P. Valent Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings Leuk Res 25 2001 543 551
23. M. Krokowski, K. Sotlar, M.T. Krauth, M. Födinger, P. Valent, and H.P. Horny Delineation of patterns of bone marrow mast cell infiltration in systemic mastocytosis: value of CD25, correlation with subvariants of the disease, and separation from mast cell hyperplasia Am J Clin Pathol 124 2005 560 568
24. L. Escribano, A. Orfao, B. Diaz-Agustin, J. Villarrubia, C. Cervero, and A. Lopez et al. Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications Blood 91 1998 2731 2736
25. L. Escribano, B. Diaz-Agustin, A. López, R.N. López, A. García-Montero, and J. Almeida et al. Immunophenotypic analysis of mast cells in mastocytosis: when and how to do it. Proposals of the Spanish network on mastocytosis (REMA) Cytometry B Clin Cytom 58B 2004 1 8
26. L. Sanchez-Munoz, C. Teodosio, J.M. Morgado, and L. Escribano Immunophenotypic characterization of bone marrow mast cells in mastocytosis and other mast cell disorders Methods Cell Biol 103 2011 333 359
27. K. Sotlar, L. Escribano, O. Landt, S. Möhrle, S. Herrero, and A. Torrelo et al. One-step detection of c-kit point mutations using PNA-mediated PCR-clamping and hybridization probes Am J Pathol 162 2003 737 746
28. W. Lawley, H. Hird, P. Mallinder, S. McKenna, B. Hargadon, and A. Murray et al. Detection of an activating c-kit mutation by real-time PCR in patients with anaphylaxis Mutat Res Fundam Mol Mech Mutagen 572 2005 1 13
29. H.A. Sampson, A. Munoz-Furlong, R.L. Campbell, N.F. Adkinson Jr., S.A. Bock, and A. Branum et al. Second symposium on the definition and management of anaphylaxis: summary report-Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium J Allergy Clin Immunol 117 2006 391 397
30. D. Gonzalez de Olano, B. de la Hoz, R. Nunez-Lopez, L. Sanchez-Munoz, M. Cuevas, and C. Dieguez et al. Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA) Clin Exp Allergy 37 2007 1547 1555
31. D. Gonzalez-de-Olano, I. varez-Twose, A. Vega, A. Orfao, and L. Escribano Venom immunotherapy in patients with mastocytosis and hymenoptera venom anaphylaxis Immunotherapy 3 2011 637 651
32. I. Alvarez-Twose, A. Matito, L. Sanchez-Munoz, J.M. Morgado, A. Orfao, and L. Escribano et al. Contribution of highly sensitive diagnostic methods to the diagnosis of systemic mastocytosis in the absence of skin lesions Allergy 67 2012 1190 1191
33. L. Escribano, I. Alvarez-Twose, L. Sanchez-Munoz, A. Garcia-Montero, R. Nunez, and J. Almeida et al. Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients J Allergy Clin Immunol 124 2009 514 521
34. C. Teodosio, A.C. Garcia-Montero, M. Jara-Acevedo, I. Alvarez-Twose, L. Sanchez-Munoz, and J. Almeida et al. An immature immunophenotype of bone marrow mast cells predicts for multilineage D816V KIT mutation in systemic mastocytosis Leukemia 26 2012 951 958
35. M. Kosnik Anaphylaxis to venom without IgE antibody Allergy 55 2000 676 677
36. D.B. Golden, J.M. Tracy, T.M. Freeman, and D.R. Hoffman Negative venom skin test results in patients with histories of systemic reaction to a sting J Allergy Clin Immunol 112 2003 495 498
37. B. Kranke, G. Sturm, and W. Aberer Negative venom skin test results and mastocytosis J Allergy Clin Immunol 113 2004 180 181
38. D. Gonzalez-de-Olano, I. Alvarez-Twose, J.M. Morgado, M.I. Lopez, A.V. Castro, and D. Diaz et al. Evaluation of basophil activation in mastocytosis with hymenoptera venom anaphylaxis Cytometry B Clin Cytom 80 2011 167 175
39. P. Bonadonna, R. Zanotti, G. Melioli, F. Antonini, I. Romano, and L. Lenzi et al. The role of basophil activation test in special populations with mastocytosis and reactions to hymenoptera sting Allergy 67 2012 962 965
40. P.W. van der Linden, C.E. Hack, J.A. Kerckhaert, A. Struyvenberg, and J.C. van der Zwan Preliminary report: complement activation in wasp-sting anaphylaxis Lancet 336 1990 904 906
41. Y. Kawabata, T.S. Yang, T.T. Yokochi, M. Matsushita, T. Fujita, and M. Shibazaki et al. Complement system is involved in anaphylactoid reaction induced by lipopolysaccharides in muramyldipeptide-treated mice Shock 14 2000 572 577
42. G.W. Volcheck, J.H. Butterfield, J.W. Yunginger, and G.G. Klee Elevated serum levels of calcitonin gene-related peptide in Hymenoptera sting-induced anaphylaxis J Allergy Clin Immunol 102 1998 149 151
43. K. Hermann, and J. Ring The renin-angiotensin system in patients with repeated anaphylactic reactions during hymenoptera venom hyposensitization and sting challenge Int Arch Allergy Immunol 112 1997 251 256
44. M. Niedoszytko, M. Ratajska, M. Chelminska, M. Makowiecki, E. Malek, and A. Sieminska et al. The angiotensinogen AGT p.M235T gene polymorphism may be responsible for the development of severe anaphylactic reactions to insect venom allergens Int Arch Allergy Immunol 153 2010 166 172
45. A.E. Dubois Mastocytosis and Hymenoptera allergy Curr Opin Allergy Clin Immunol 4 2004 291 295
46. N. Wagner, D. Fritze, B. Przybilla, M. Hagedorn, and F. Rueff Fatal anaphylactic sting reaction in a patient with mastocytosis Int Arch Allergy Immunol 146 2008 162 163
47. U.R. Muller Elevated baseline serum tryptase, mastocytosis and anaphylaxis Clin Exp Allergy 39 2009 620 622
48. P. Bonadonna, R. Zanotti, B. Caruso, L. Castellani, O. Perbellini, and S. Colarossi et al. Allergen specific immunotherapy is safe and effective in patients with systemic mastocytosis and Hymenoptera allergy J Allergy Clin Immunol 121 2008 256 257
49. D. Gonzalez de Olano, I. Alvarez-Twose, M.I. Esteban-Lopez, L. Sanchez-Munoz, M.D. de Durana, and A. Vega et al. Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis J Allergy Clin Immunol 121 2008 519 526
50. M. Niedoszytko, J. de Monchy, J.J. Van Doormaal, E. Jassem, and J.N. Oude Elberink Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy Allergy 64 2009 1237 1245