Validation of the REMA score for predicting mast cell clonality and systemic mastocytosis in patients with systemic mast cell activation symptoms

International Archives of Allergy and Immunology

Volumn 157, Issue 3, 2012, Pages 275-280

  Alvarez Twose, I ^a,d   Gonzalez De Olano D ^b,d   Sanchez Munoz L ^a,d   Matito, A ^a,d   Jara Acevedo, M ^c,d   Teodosio, C ^c,d   Garcia Montero A ^c,d   Morgado, J M ^a,d   Orfao, A ^c,d   Escribano, Luis ^a,d  

^a HOSPITAL VIRGEN DE LA SALUD   (Spain)

^b HOSPITAL UNIVERSITARIO DE FUENLABRADA   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d Red Española de Mastocitosis REMA   (Spain)

Author keywords

Clonality; Mast cell; Mast cell activation syndrome; Mastocytosis; Tryptase

Indexed keywords

ANTIBIOTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; TRYPTASE;

ABDOMINAL CRAMP; ADOLESCENT; ADULT; AGED; ANGIONEUROTIC EDEMA; ARTICLE; CLINICAL ASSESSMENT TOOL; CLONAL VARIATION; DIARRHEA; DIZZINESS; DYSPNEA; FEMALE; FEVER; FLUSHING; GENDER; HEADACHE; HEART ARREST; HEART PALPITATION; HUMAN; HYPERTENSION; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MAST CELL; MAST CELL ACTIVATION SYMPTOM; NAUSEA; ONCOGENE C KIT; PARESTHESIA; PRESYNCOPE; PRIORITY JOURNAL; PRURITUS; RECEIVER OPERATING CHARACTERISTIC; REMA SCORE; RHINOCONJUNCTIVITIS; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SKIN DISEASE; SYMPTOMATOLOGY; SYNCOPE; SYSTEMIC MASTOCYTOSIS; URTICARIA; VALIDATION STUDY; VOMITING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; DECISION SUPPORT TECHNIQUES; FEMALE; HUMANS; MALE; MAST CELLS; MASTOCYTOSIS, SYSTEMIC; MIDDLE AGED; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS C-KIT; PRURITUS; ROC CURVE; SEX FACTORS; SYNCOPE; TRYPTASES; URTICARIA; YOUNG ADULT;

EID: 80055002513     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000329856     Document Type: Article

References (15)

1. Akin C, Valent P, Metcalfe DD: Mast cell activation syndrome: Proposed diagnostic criteria. J Allergy Clin Immunol 2010; 126: 1099-1104.
2. Valent P, Akin C, Escribano L, Fodinger M, Hartmann K, Brockow K, Castells M, Sperr WR, Kluin-Nelemans HC, Hamdy NA, Lortholary O, Robyn J, van Doormaal J, Sotlar K, Hauswirth AW, Arock M, Hermine O, Hellmann A, Triggiani M, Niedoszytko M, Schwartz LB, Orfao A, Horny HP, Metcalfe DD: Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest 2007; 37: 435-453. (Pubitemid 46817344)
3. Alvarez-Twose I, Gonzalez de Olano D, Sanchez-Munoz L, Matito A, Esteban-Lopez MI, Vega A, Mateo MB, Alonso Diaz de Durana MD, de la Hoz B, Del Pozo MD, Caballero T, Rosado A, Sanchez-Matas I, Teodosio C, Jara-Acevedo M, Mollejo M, Garcia-Montero A, Orfao A, Escribano L: Clinical, biological and molecular characteristics of systemic mast cell disorders presenting with severe mediator-related symptoms. J Allergy Clin Immunol 2010; 125: 1269-1278.
4. Horny HP, Metcalfe DD, Bennet JM, Bain BJ, Akin C, Escribano L, Valent P: Mastocytosis; in Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds): WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, IARC, 2008, pp 54-63.
5. Metcalfe DD, Schwartz LB: Assessing anaphylactic risk? Consider mast cell clonality. J Allergy Clin Immunol 2009; 123: 687-688.
6. Ferrer M, Nunez-Cordoba JM, Luquin E, Grattan CE, De la Borbolla JM, Sanz ML, Schwartz LB: Serum total tryptase levels are increased in patients with active chronic urticaria. Clin Exp Allergy 2010; 40: 1760-1766.
7. Sperr WR, El-Samahi A, Kundi M, Girschikofsky M, Winkler S, Lutz D, Endler G, Rumpold H, Agis H, Sillaber C, Jager U, Valent P: Elevated tryptase levels selectively cluster in myeloid neoplasms: A novel diagnostic approach and screen marker in clinical haematology. Eur J Clin Invest 2009; 39: 914-923.
8. Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, Brown SG, Camargo CA Jr, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD Jr, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW: Second symposium on the definition and management of anaphylaxis: Summary report -Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol 2006; 117: 391-397. (Pubitemid 43190153)
9. Escribano L, Avarez-Twose I, Sanchez-Munoz L, Garcia-Montero A, Nunez R, Almeida J, Jara-Acevedo M, Teodosio C, Garcia-Cosio M, Bellas C, Orfao A: Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. J Allergy Clin Immunol 2009; 124: 514-521.
10. Sanchez-Munoz L, Alvarez-Twose I, Garcia-Montero AC, Teodosio C, Jara-Acevedo M, Pedreira CE, Matito A, Morgado JM, Sanchez ML, Mollejo M, Gonzalez-de-Olano D, Orfao A, Escribano L: Evaluation of the WHO criteria for the classification of patients with mastocytosis. Mod Pathol 2011; 24: 1157-1168.
11. Escribano L, Diaz-Agustin B, López A, López RN, García-Montero A, Almeida J, Prados A, Angulo M, Herrero S, Orfao A, Spanish NM: Immunophenotypic analysis of mast cells in mastocytosis: When and how to do it. Proposals of the Spanish network on mastocytosis (REMA). Cytometry B Clin Cytom 2004; 58B:1-8. (Pubitemid 38332714)
12. Sanchez-Munoz L, Teodosio C, Morgado JM, Escribano L: Immunophenotypic characterization of bone marrow mast cells in mastocytosis and other mast cell disorders. Methods Cell Biol 2011; 103: 333-359.
13. Garcia-Montero AC, Jara-Acevedo M, Teodosio C, Sanchez ML, Nunez R, Prados A, Aldanondo I, Sanchez L, Dominguez M, Botana LM, Sanchez-Jimenez F, Sotlar K, Almeida J, Escribano L, Orfao A: KIT mutation in mast cells and other bone marrow haematopoietic cell lineages in systemic mast cell disorders. A prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood 2006; 108: 2366-2372. (Pubitemid 44497521)
14. Wu Y, Basir Z, Kajdacsy-Balla A, Strawn E, Macias V, Montgomery K, Guo SW: Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay. Fertil Steril 2003; 79(Suppl 1):710-717. (Pubitemid 36279674)
15. DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics 1988; 44: 837-845.