Immunophenotypic Characterization of Bone Marrow Mast Cells in Mastocytosis and Other Mast Cell Disorders

Methods in Cell Biology

Volumn 103, Issue , 2011, Pages 333-359

  Sánchez Muñoz, Laura ^a   Teodósio, Cristina ^b   Morgado, José M ^a   Escribano, Luis ^a  

^a HOSPITAL VIRGEN DE LA SALUD   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Bone Marrow; Enumeration; Mast cell; Mastocytosis; Organic fluid; Peripheral

Indexed keywords

BIOLOGICAL MARKER; CD2 ANTIGEN; FLUORESCENT DYE; INTERLEUKIN 2 RECEPTOR ALPHA; MONOCLONAL ANTIBODY;

BONE MARROW; BOOK; CELL COUNT; CHEMISTRY; CLASSIFICATION; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; IMMUNOPHENOTYPING; MAST CELL; MASTOCYTOSIS; METABOLISM; METHODOLOGY; PATHOLOGY;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD2; BIOLOGICAL MARKERS; BONE MARROW; CELL COUNT; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MAST CELLS; MASTOCYTOSIS;

EID: 79959733131     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385493-3.00014-0     Document Type: Book

References (98)

1. Abraham S.N., St John A.L. Mast cell-orchestrated immunity to pathogens. Nat. Rev. Immunol. 2010, 10:440-452.
2. Agis H., Fureder W., Bankl H.C., Kundi M., Sperr W.R., Willheim M., Boltz-Nitulescu G., Butterfield J.H., Kishi K., Lechner K., Valent P. Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. Immunology 1996, 87:535-543.
3. -, colony-forming cell. J. Immunol. 1993, 151:4221-4227.
4. Akin C., Escribano L., Núñez R., García-Montero A., Angulo M., Orfao A., Metcalfe D.D. Well-differentiated systemic mastocytosis: A new disease variant with mature mast cell phenotype and lack of Codon 816 c-Kit mutations. J. Allergy Clin. Immunol. 2004, 113(2):S327.
5. Akin C., Fumo G., Yavuz A.S., Lipsky P.E., Neckers L., Metcalfe D.D. A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood 2004, 103:3222-3225.
6. Akin C., Schwartz L.B., Kitoh T., Obayashi H., Worobec A.S., Scott L.M., Metcalfe D.D. Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology. Blood 2000, 96:1267-1273.
7. Alvarez-Twose I., Gonzalez de Olano D., Sanchez-Munoz L., Matito A., Esteban-Lopez M.I., Vega A., Mateo M.B., Alonso Diaz de Durana M.D., de la Hoz B., Del Pozo M.D., Caballero T., Rosado A., Sanchez-Matas I., Teodosio C., Jara-Acevedo M., Mollejo M., Garcia-Montero A., Orfao A., Escribano L. Clinical, biological and molecular characteristics of systemic mast cell disorders presenting with severe mediator-related symptoms. J. Allergy Clin. Immunol. 2010, 125:1269-1278.
8. Alvarez-Twose I., Gonzalez de O.D., Sanchez-Munoz L., Teodosio C., Jara-Acevedo M., Sanchez-Matas I., Matito A., Garcia-Montero A., Orfao A., Escribano L. Clinical, biological and molecular characteristics of mast cell activation disorders: a prospective study in 62 patients by the Spanish Network on mastocytosis (REMA). J. Allergy Clin. Immunol. 2009, 123(2):S141.
9. Ashman L.K., Cambareri A.C., To L.B., Levinsky R.J., Juttner C.A. Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow. Blood 1991, 78:30-37.
10. Bodni R.A., Sapia S., Galeano A., Kaminsky A. Indolent systemic mast cell disease: immunophenotypic characterization of bone marrow mast cells by flow cytometry. J. Eur. Acad. Dermatol. Venereol. 2003, 17:160-166.
11. Bonadonna P., Perbellini O., Passalacqua G., Caruso B., Colarossi S., Dal F.D., Castellani L., Bonetto C., Frattini F., Dama A., Martinelli G., Chilosi M., Senna G., Pizzolo G., Zanotti R. Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels. J. Allergy Clin. Immunol. 2009, 123:680-686.
12. Bühring H.J., Simmons P.J., Pudney M., Müller R., Jarrossay D., Van Agthoven A., Willheim M., Brugger W., Valent P., Kanz L. The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors. Blood 1999, 94:2343-2356.
13. Cerveró C., Escribano L., Orfao A., Díaz Agustín B., Bravo P., Villarrubia J., García-Sanz R., Velasco J.L., Herrera P., Vargas M., González M., Navarro J.L., San Miguel J.F. Expression of bcl-2 by human bone marrow mast cells and its overexpression in mast cell leukemia. Am. J. Hematol. 1999, 60:191-195.
14. Claman H.N., Choi K.L., Sujansky W., Vatter A.E. Mast cell " disappearance" in murine graft-vs-host disease (GVHD). Ultrastructural demonstration of " phantom mast cells" J. Immunol. 1986, 137:2009-2013.
15. Dahl C., Hoffmann H.J., Saito H., Schiotz P.O. Human mast cells express receptors for IL-3, IL-5 and GM-CSF; a partial map of receptors on human mast cells cultured in vitro. Allergy 2004, 59:1087-1096.
16. Dahl C., Saito H., Nielsen H.V., Schiotz P.O. The establishment of a combined serum-free and serum-supplemented culture method of obtaining functional cord blood-derived human mast cells. J. Immunol. Methods 2002, 262:137-143.
17. Dalton R., Chan L., Batten E., Eridani S. Mast cell leukaemia: evidence for bone marrow origin of the pathological clone. Br. J. Haematol. 1986, 64:397-406.
18. Diaz-Agustin B., Escribano L., Bravo P., Herrero S., Nunez R., Navalon R., Navarro L., Torrelo A., Cantalapiedra A., Del Castillo L., Villarrubia J., Navarro J.L., San Miguel J.F., Orfao A. The CD69 early activation molecule is overexpressed in human bone marrow mast cells from adults with indolent systemic mast cell disease. Br. J. Haematol. 1999, 106:400-405.
19. Ehrlich P. Beiträge zur Kenntniss der granulierten Bindegewebszellen und der Eosinophilen Leukocyten. Arch. Anat. Physiol. 1879, 3:166-169.
20. Ellis J. Urticaria pigmentosa: a report of a case of autopsy. Arch. Pathol. 1949, 48:426-435.
21. Escribano L., Avarez-Twose I., Sanchez-Munoz L., Garcia-Montero A., Nunez R., Almeida J., Jara-Acevedo M., Teodosio C., Garcia-Cosio M., Bellas C., Orfao A. Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish network on mastocytosis in a series of 145 patients. J. Allergy Clin. Immunol. 2009, 124:514-521.
22. Escribano L., Díaz Agustín B., Bellas C., Navalón R., Núñez R., Sperr W., Schernthaner G., Valent P., Orfao A. Utility of flow cytometric analysis of mast cells in the diagnosis and classification of adult mastocytosis. Leuk. Res. 2001, 25:563-570.
23. Escribano L., Díaz Agustín B., Bravo P., Navalón R., Almeida J., Orfao A. Immunophenotype of bone marrow mast cells in indolent systemic mast cell disease in adults. Leuk. Lymphoma 1999, 35:227-235.
24. Escribano L., Diaz-Agustin B., López A., López R.N., García-Montero A., Almeida J., Prados A., Angulo M., Herrero S., Orfao A., Spanish N.M. Immunophenotypic analysis of mast cells in mastocytosis: when and how to do it. Proposals of the Spanish network on mastocytosis (REMA). Cytometry 2004, 58B:1-8.
25. Escribano L., Diaz-Agustin B., Nunez R., Prados A., Rodriguez R., Orfao A. Abnormal expression of CD antigens in mastocytosis. Int. Arch. Allergy Immunol. 2002, 127:127-132.
26. Escribano L., Garcia Montero A.C., Nunez R., Orfao A. Flow cytometric analysis of normal and neoplastic mast cells: role in diagnosis and follow-up of mast cell disease. Immunol. Allergy Clin. North Am. 2006, 26:535-547.
27. Escribano L., Ocqueteau M., Almeida J., Orfao A., San Miguel J.F. Expression of the c-kit (CD117) molecule in normal and malignant hematopoiesis. Leuk. Lymphoma 1998, 30:459-466.
28. Escribano L., Orfao A., Díaz Agustín B., Cerveró C., Herrero S., Villarrubia J., Bravo P., Torrelo A., Montero T., Valdemoro M., Velasco J.L., Navarro J.L., San Miguel J.F. Human bone marrow mast cells from indolent systemic mast cell disease constitutively express increased amounts of the CD63 protein on their surface. Cytometry 1998, 34:223-228.
29. Escribano L., Orfao A., Diaz-Agustin B., Villarrubia J., Cervero C., Lopez A., Marcos M.A., Bellas C., Fernandez-Canadas S., Cuevas M., Sanchez A., Velasco J.L., Navarro J.L., Miguel J.F. Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrowmastcells and its diagnostic implications. Blood 1998, 91:2731-2736.
30. Escribano L., Orfao A., Villarrubia J., Cerveró C., Velasco J.L., Martin F., San Miguel J.F., Navarro J.L. Expression of lymphoid-associated antigens in mast cells: report of a case of systemic mast cell disease. Br. J. Haematol. 1995, 91:941-943.
31. Escribano L., Orfao A., Villarrubia J., Díaz Agustín B., Cerveró C., Ríos A., Velasco J.L., Ciudad J., Navarro J.L., San Miguel J.F. Immunophenotypic characterization of human bone marrow mast cells. A flow cytometric study of normal and pathological bone marrow samples. Ann. Cell. Pathol. 1998, 16:151-159.
32. Escribano L., Orfao A., Villarrubia J., Martín F., Madruga J.I., Cuevas M., Velasco J.L., Rios A., San Miguel J.F. Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. Cytometry 1997, 30:98-102.
33. Frandji P., Oskéritzian C., Cacaraci F., Lapeyre J., Peronet R., David B., Guillet J.-G., Mécheri S. Antigen-dependent stimulation by bone marrow-derived mast cells of MHC class II-restricted T cell hybridoma. J. Immunol. 1993, 151:6318-6328.
34. Furuno T., Teshima R., Kitani S., Sawada J., Nakanishi M. Surface expression of CD63 antigen (AD1 antigen) in P815 mastocytoma cells by transfected IgE receptors. Biochem. Biophys. Res. Commun. 1996, 219:740-744.
35. Galli S.J., Nakae S., Tsai M. Mast cells in the development of adaptive immune responses. Nat. Immunol. 2005, 6:135-142.
36. Gane P., Pecquet C., Crespeau H., Lambin P., Leynadier F., Rouger P. Flow cytometric monitoring of allergen induced basophil activation. Cytometry 1995, 19:361-365.
37. Garcia-Montero A.C., Jara-Acevedo M., Teodosio C., Sanchez M.L., Nunez R., Prados A., Aldanondo I., Sanchez L., Dominguez M., Botana L.M., Sanchez-Jimenez F., Sotlar K., Almeida J., Escribano L., Orfao A. KIT mutation in mast cells and other bone marrow haematopoietic cell lineages in systemic mast cell disorders. A prospective study of the Spanish network on mastocytosis (REMA) in a series of 113 patients. Blood 2006, 108:2366-2372.
38. Ghannadan M., Baghestanian M., Wimazal F., Eisenmenger M., Latal D., Kargül G., Walchshofer S., Sillaber C., Lechner K., Valent P. Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies. J. Invest. Dermatol. 1998, 111:689-695.
39. -7. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:537-541.
40. Gross H.J., Verwer B., Houck D., Recktenwald D. Detection of rare cells at a frequency of one per million by flow cytometry. Cytometry 1993, 14:519-526.
41. Hauswirth A.W., Escribano L., Prados A., Nunez R., Mirkina I., Kneidinger M., Florian S., Sonneck K., Vales A., Schernthaner G.H., Sanchez-Munoz L., Sperr W.R., Buhring H.J., Orfao A., Valent P. CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross-linking. Int. J. Immunopathol. Pharmacol. 2008, 21:797-806.
42. Henz B.M., Maurer M., Lippert U., Worm M., Babina M. Mast cells as initiators of immunity and host defense. Exp. Dermatol. 2001, 10:1-10.
43. Horny H.P., Sillaber C., Menke D., Kaiserling E., Wehrmann M., Stehberger B., Chott A., Lechner K., Lennert K., Valent P. Diagnostic value of immunostaining for tryptase in patients with mastocytosis. Am. J. Surg. Pathol. 1998, 22:1132-1140.
44. Horny H.P., Metcalfe D.D., Bennet J.M., Bain B.J., Akin C., Escribano L., Valent P. Mastocytosis. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 2008, 54-63. IARC, Lyon. S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein, J. Thiele, J.W. Vardiman (Eds.).
45. Iida M., Matsumoto K., Tomita H., Nakajima T., Akasawa A., Ohtani N.Y., Yoshida N.L., Matsui K., Nakada A., Sugita Y., Shimizu Y., Wakahara S., Nakao T., Fujii Y., Ra C., Saito H. Selective down-regulation of high-affinity IgE receptor (Fce{open}RI) α-chain messenger RNA among transcriptome in cord blood-derived versus adult peripheral blood-derived cultured human mast cells. Blood 2001, 97:1016-1022.
46. Johansson O., Virtanen M., Hilliges M., Yang Q. Histamine immunohistochemistry: a new and highly sensitive method for studying cutaneous mast cells. Histochem. J. 1992, 24:283-287.
47. Kambe N., Kambe M., Chang H.W., Matsui A., Min H.K., Hussein M., Oskerizian C.A., Kochan J., Irani A.M.A., Schwartz L.B. An improved procedure for the development of human mast cells from dispersed fetal liver cells in serum-free culture medium. J. Immunol. Methods 2000, 240:101-110.
48. Kempuraj D., Saito H., Kaneko A., Fukagawa K., Nakayama M., Toru H., Tomikawa M., Tachimoto H., Ebisawa M., Akasawa A., Miyagi T., Kimura H., Nakajima T., Tsuji K., Nakahata T. Characterization of mast cell-committed progenitors present in human umbilical cord blood. Blood 1999, 93:3338-3346.
49. +, and expresses aminopeptidase N (CD13). Blood 1999, 94:2333-2342.
50. + bone marrow progenitor cells. J. Immunol. 1991, 146:1410-1415.
51. Klion A.D., Noel P., Akin C., Law M.A., Gilliland D.G., Cools J., Metcalfe D.D., Nutman T.B. Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood 2003, 101:4660-4666.
52. Leary J.F. Strategies for rare cell detection and isolation. Methods Cell Biol. 1994, 42(Pt B):331-358.
53. Leary J.F., Schmidt D.F., Gram J.G., McLaughlin S.R., Dalla T.C., Burde S. High-speed flow cytometric analysis and sorting of human fetal cells from maternal blood for molecular characterization. Ann. N.Y. Acad. Sci. 1994, 731:1981.
54. Lerner N.B., Nocka K.H., Cole S.R., Qiu F.H., Strife A., Ashman L.K., Besmer P. Monoclonal antibody YB5.B8 identifies the human c-kit protein product. Blood 1991, 77:1876-1883.
55. Li L., Li Y., Reddel S.W., Cherrian M., Friend D.S., Stevens R.L., Krilis S.A. Identification of basophilic cells that express mast cell granule proteases in the peripheral blood of asthma, allergy, and drug-reactive patients. J. Immunol. 1998, 161:5079-5086.
56. Lim K.H., Tefferi A., Lasho T.L., Finke C., Patnaik M., Butterfield J.H., McClure R.F., Li C.Y., Pardanani A. Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood 2009, 113:5727-5736.
57. Longley B.J., Metcalfe D.D., Tharp M., Wang X.M., Tyrrell L., Lu S.Z., Heitjan D., Ma Y.S. Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:1609-1614.
58. Longley B.J., Tyrrell L., Lu S.Z., Ma Y.S., Langley K., Ding T.G., Duffy T., Jacobs P., Tang L.H., Modlin I. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat. Genet. 1996, 12:312-314.
59. Marshall J.S. Mast-cell responses to pathogens. Nat. Rev. Immunol. 2004, 4:787-799.
60. Matarraz S., Lopez A., Barrena S., Fernandez C., Jensen E., Flores J., Barcena P., Rasillo A., Sayagues J.M., Sanchez M.L., Hernandez-Campo P., Hernandez Rivas J.M., Salvador C., Fernandez-Mosteirin N., Giralt M., Perdiguer L., Orfao A. The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors. Leukemia 2008, 22:1175-1183.
61. Mayrhofer G., Gadd S.J., Spargo L.D., Ashman L.K. Specificity of a mouse monoclonal antibody raised against acute myeloid leukaemia cells for mast cells in human mucosal and connective tissues. Immunol. Cell Biol. 1987, 65(Pt. 3):241-250.
62. Metcalfe D.D. Classification and diagnosis of mastocytosis: current status. J. Invest Dermatol. 1991, 96:2S-4S.
63. McKenna M.J. Histomorphometric study of mast cells in normal bone, osteoporosis, and mastocytosis using a new stain. Calcif. Tissue Int. 1994, 55:257-259.
64. Nagata H., Worobec A.S., Oh C.K., Chowdhury B.A., Tannenbaum S., Suzuki Y., Metcalfe D.D. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:10560-10564.
65. Nettleship J., Tay W. Rare forms of urticaria. Br. Med. J. 1869, 2:323-324.
66. Núñez R., Akin C., Díaz Agustín B., López A., Prados A., García-Montero A., Almeida J., García-Belmonte D., Metcalfe D., Escribano L. Immunophenotypical profile of CD25-expressing mast cells in mastocytosis. Clin. Cytom. 2003, 56B(1):72-73.
67. Nuñez R., Escribano L., Schernthaner G., Prados A., Rodriguez-Gonzalez R., Diaz-Agustin B., Lopez A., Hauswirth A., Valent P., Almeida J., Bravo P., Orfao A. Overexpression of complement receptors and related antigens on the surface of bone marrow mast cells in patients with systemic mastocytosis. Br. J. Haematol. 2002, 120:257-265.
68. Orfao A., Escribano L., Villarrubia J., Velasco J.L., Cerveró C., Ciudad J., Navarro J.L., San Miguel J.F. Flow cytometric analysis of mast cells from normal and pathological human bone marrow samples. Identification and enumeration. Am. J. Pathol. 1996, 149:1493-1499.
69. Orfao A., Garcia-Montero A.C., Sanchez L., Escribano L. Recent advances in the understanding of mastocytosis: the role of KIT mutations. Br. J. Haematol. 2007, 138:12-30.
70. Pardanani A., Kimlinger T., Reeder T., Li C.Y., Tefferi A. Bone marrow mast cell immunophenotyping in adults with mast cell disease: a prospective study of 33 patients. Leuk. Res. 2004, 28:777-783.
71. Pardanani A., Reeder T., Li C.Y., Tefferi A. Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia. Leuk. Res. 2003, 27:883-885.
72. Prokocimer M., Polliack A. Increased bone marrow mast cells in preleukemic syndromes, acute leukemia, and lymphoproliferative disorders. Am. J. Clin. Pathol. 1981, 75:34-38.
73. Roederer, M. (2002). Multiparameter FACS analysis. Curr. Protoc. Immunol. Chapter 5, Unit 5.8.
74. - cell population. Blood 1994, 84:2489-2496.
75. Sale G.E., Marmont P. Marrow mast cell counts do not predict bone marrow graft rejection. Hum. Pathol. 1981, 12:605-608.
76. Schernthaner G.H., Hauswirth A.W., Baghestanian M., Agis H., Ghannadan M., Worda C., Krauth M.T., Printz D., Fritsch G., Sperr W.R., Valent P. Detection of differentiation- and activation-linked cell surface antigens on cultured mast cell progenitors. Allergy 2005, 60:1248-1255.
77. Schernthaner G.H., Jordan J.H., Ghannadan M., Agis H., Bevec D., Nunez R., Escribano L., Majdic O., Willheim M., Worda C., Printz D., Fritsch G., Lechner K., Valent P. Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells. Blood 2001, 98:3784-3792.
78. Sézary A., Levy-Coblentz G., Chauvillon P. Dermographisme et mastocytose. Bull. Soc. Fr. Dermatol. Syphiligr. 1936, 43:359-361.
79. + cells cultured in the presence of stem cell factor and interleukin-6. Interleukin-4 is not required for constitutive expression of CD54, Fce{open}RIα and chymase, and CD13 expression is reduced during differentiation. Clin. Exp. Allergy 2002, 32:872-880.
80. + bone marrow progenitors. Clin. Exp. Allergy 2004, 34:1719-1724.
81. Sperr W.R., Jordan J.H., Baghestanian M., Kiener H.P., Samorapoompichit P., Semper H., Hauswirth A., Schernthaner G.H., Chott A., Natter S., Kraft D., Valenta R., Schwartz L.B., Geissler K., Lechner K., Valent P. Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. Blood 2001, 98:2200-2209.
82. Sperr W.R., Stehberger B., Wimazal F., Baghestanian M., Schwartz L.B., Kundi M., Semper H., Jordan J.H., Chott A., Drach J., Jäger U., Geissler K., Greschniok A., Horny H.P., Lechner K., Valent P. Serum tryptase measurements in patients with myelodysplastic syndromes. Leuk. Lymphoma 2002, 43:1097-1105.
83. Tedla N., Lee C.W., Borges L., Geczy C.L., Arm J.P. Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells. J. Leuk. Biol. 2008, 83:334-343.
84. Teodosio C., Garcia-Montero A.C., Jara-Acevedo M., Sanchez-Munoz L., varez-Twose I., Nunez R., Schwartz L.B., Walls A.F., Escribano L., Orfao A. Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes. J. Allergy Clin. Immunol. 2010, 125:719-726.
85. + cells. Blood 1994, 84:2930-2939.
86. Unna P.G. Bëitrage zur anatomie und pathogenese der urticaria simplex und pigmentosa. Mschr. Prakt. Dermatol. Suppl. Dermatol. Stud. 1887, 3:9.
87. Valent P., Agis H., Sperr W., Sillaber C., Horny H.P. Diagnostic and prognostic value of new biochemical and immunohistochemical parameters in chronic myeloid leukemia. Leuk. Lymphoma 2008, 49:635-638.
88. Valent P., Akin C., Escribano L., Fodinger M., Hartmann K., Brockow K., Castells M., Sperr W.R., Kluin-Nelemans H.C., Hamdy N.A., Lortholary O., Robyn J., van D.J., Sotlar K., Hauswirth A.W., Arock M., Hermine O., Hellmann A., Triggiani M., Niedoszytko M., Schwartz L.B., Orfao A., Horny H.P., Metcalfe D.D. Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. Eur. J. Clin. Invest. 2007, 37:435-453.
89. Valent P., Bettelheim P. Cell surface structures on human basophils and mast cells: biochemical and functional characterization. Adv. Immunol. 1992, 52:333-423.
90. Valent P., Horny H.P., Escribano L., Longley-BJ J., Li C.L., Schwartz L.B., Marone G., Núñez R., Akin C., Sotlar K., Sperr W., Wolff K., Brunning R.D., Parwaresch R.M., Austen K.F., Lennert A.K., Metcalfe D., Vardiman J.W., Bennet J.M. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk. Res. 2001, 25:603-625.
91. Valent P., Majdic O., Maurer D., Bodger M., Muhm M., Bettelheim P. Further characterization of surface membrane structures expressed on human basophils and mast cells. Int. Arch. Allergy Appl. Immunol. 1990, 91:198-203.
92. Valent P., Schernthaner G.H., Agis H., Fritsch G., Willheim M., Büring H.J., Orfao A., Escribano L. Variable expression of activation-linked surface antigens on human mast cells in health and disease. Immunol. Rev. 2001, 179:74-81.
93. Wong G.H., Clark-Lewis I., Kimm-Breschkin J.L., Schrader J.W. Interferon-gamma-like molecule induces Ia antigens on cultured mast cell progenitors. Proc. Natl. Acad. Sci. U.S.A. 1982, 79:6989-6993.
94. Woolhiser M.R., Okayama Y., Gilfillan A.M., Metcalfe D.D. IgG-dependent activation of human mast cells following up-regulation of FcgammaRI by IFN-gamma. Eur. J. Immunol. 2001, 31:3298-3307.
95. Yavuz A.S., Lipsky P.E., Yavuz S., Metcalfe D.D., Akin C. Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood 2002, 100:661-665.
96. Yokoi H., Myers A., Matsumoto K., Crocker P.R., Saito H., Bochner B.S. Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells. Allergy 2006, 61:769-776.
97. Yoo D., Lessin L.S. Bone marrow mast cell content in preleukemic syndrome. Am. J. Med. 1982, 73:539-542.
98. Yoo D., Lessin L.S., Jensen W.N. Bone-marrow mast cells in lymphoproliferative disorders. Ann. Intern. Med. 1978, 88:753-757.