Synthetic liver X receptor agonist T0901317 attenuates high glucose-induced oxidative stress, mitochondrial damage and apoptosis in cardiomyocytes

Acta Histochemica

Volumn 116, Issue 1, 2014, Pages 214-221

  Cheng, Yongxia ^a,b   Feng, Yukuan ^a,b   Zhu, Min ^a   Yan, Bin ^a   Fu, Songbin ^b   Guo, Jin ^c   Hu, Jing ^a   Song, Xiandong ^a   Guo, Sufen ^a   Liu, Guibo ^a  

^a MUDANJIANG MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c JIAMUSI UNIVERSITY   (China)

Author keywords

Apoptosis; Cardiomyocytes; High glucose; Liver X receptor agonist T0901317; Mitochondrial damage

Indexed keywords

FLUORINATED HYDROCARBON; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; PROTEIN BINDING; REACTIVE OXYGEN METABOLITE; SULFONAMIDE; TO-901317;

AGONISTS; ANIMAL; APOPTOSIS; CELL LINE; DIABETIC CARDIOMYOPATHY; DRUG EFFECTS; HEART MITOCHONDRION; HEART MUSCLE CELL; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; RAT; TRANSCRIPTION INITIATION;

ANIMALS; APOPTOSIS; CELL LINE; DIABETIC CARDIOMYOPATHIES; GLUCOSE; HYDROCARBONS, FLUORINATED; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; NF-KAPPA B; ORPHAN NUCLEAR RECEPTORS; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; REACTIVE OXYGEN SPECIES; SULFONAMIDES; TRANSCRIPTIONAL ACTIVATION;

EID: 84894904014     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2013.07.007     Document Type: Article

References (40)

1. Arnoult D., Parone P., Martinou J.C., Antonsson B., Estaquier J., Ameisen J.C. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 2002, 159:923-929.
2. Baeuerle P.A., Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 1994, 12:141-179.
3. Baranowski M. Biological role of liver X receptors. J Physiol Pharmacol 2008, 59(7):31-55.
4. Battiprolu P.K., Gillette T.G., Wang Z.V., Lavandero S., Hill J.A. Diabetic cardiomyopathy: mechanisms and therapeutic targets. Drug Discov Today Dis Mech 2010, 7:e135-e143.
5. Cai L., Li W., Wang G., Guo L., Jiang Y., Kang Y.J. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 2002, 51:1938-1948.
6. Calkin A.C., Tontonoz P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nat Rev Mol Cell Biol 2012, 13:213-224.
7. Cao G., Liang Y., Broderick C.L., Oldham B.A., Beyer T.P., Schmidt R.J., et al. Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem 2003, 278:1131-1136.
8. Chang L., Zhang Z., Li W., Dai J., Guan Y., Wang X. Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway. Biochem Biophys Res Commun 2007, 357:772-778.
9. Chawla A., Repa J.J., Evans R.M., Mangelsdorf D.J. Nuclear receptors and lipid physiology: opening the X-files. Science 2001, 294:1866-1870.
10. Chen Y., Saari J.T., Kang Y.J. Weak antioxidant defenses make the heart a target for damage in copper-deficient rats. Free Radic Biol Med 1994, 17:529-536.
11. Desagher S., Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000, 10:369-377.
12. El Roz A., Bard J.M., Huvelin J.M., Nazih H. LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. Anticancer Res 2012, 32:3007-3013.
13. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1309-1312.
14. Gross A., McDonnell J.M., Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999, 13:1899-1911.
15. Khan N., Afaq F., Mukhtar H. Apoptosis by dietary factors: the suicide solution for delaying cancer growth. Carcinogenesis 2007, 28:233-239.
16. Kuo W.W., Wang W.J., Tsai C.Y., Way C.L., Hsu H.H., Chen L.M. Diallyl trisulfide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFkappaB signaling via attenuating ROS generation. Int J Cardiol 2012, 10.1016/j.ijcard.2012.09.080.
17. Li X., Song Y., Han Y., Wang D., Zhu Y. Liver X receptor agonist alleviated high glucose-induced endothelial progenitor cell dysfunction via inhibition of reactive oxygen species and activation of AMP-activated protein kinase. Microcirculation 2012, 19:547-553.
18. Liang H., Zhong Y., Zhou S., Li Q.Q. Palmitic acid-induced apoptosis in pancreatic beta-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate. In Vivo 2011, 25:711-718.
19. Liu Y., Han X., Bian Z., Peng Y., You Z., Wang Q., et al. Activation of liver X receptors attenuates endotoxin-induced liver injury in mice with nonalcoholic fatty liver disease. Dig Dis Sci 2012, 57:390-398.
20. Liu Y., Yan C., Wang Y., Nakagawa Y., Nerio N., Anghel A., et al. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology 2006, 147:5061-5068.
21. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998, 94:481-490.
22. Ly J.D., Grubb D.R., Lawen A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis: an update. Apoptosis 2003, 8:115-128.
23. Miller D.H., Fischer A.K., Chu K.F., Burr R., Hillenmeyer S., Brard L., et al. T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected]. Int J Gynecol Cancer 2011, 21:1350-1356.
24. Murarka S., Movahed M.R. Diabetic cardiomyopathy. J Card Fail 2010, 16:971-979.
25. Oeckinghaus A., Hayden M.S., Ghosh S. Crosstalk in NF-kappaB signaling pathways. Nat Immunol 2011, 12:695-708.
26. Pommier A.J., Alves G., Viennois E., Bernard S., Communal Y., Sion B., et al. Liver X receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene 2010, 29:2712-2723.
27. Rough J.J., Monroy M.A., Yerrum S., Daly J.M. Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells. J Ovarian Res 2010, 3:13.
28. Schainberg A., Ribeiro-Oliveira A., Ribeiro J.M. Is there a link between glucose levels and heart failure? An update. Arq Bras Endocrinol Metabol 2010, 54:488-497.
29. Shen E., Li Y., Shan L., Zhu H., Feng Q., Arnold J.M., et al. Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. Diabetes 2009, 58:2386-2395.
30. Smiley S.T., Reers M., Mottola-Hartshorn C., Lin M., Chen A., Smith T.W., et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A 1991, 88:3671-3675.
31. Tsai K.H., Wang W.J., Lin C.W., Pai P., Lai T.Y., Tsai C.Y., et al. NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-kappaB in cardiomyocytes exposed to high glucose. J Cell Physiol 2012, 227:1347-1357.
32. Valledor A.F., Hsu L.C., Ogawa S., Sawka-Verhelle D., Karin M., Glass C.K. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A 2004, 101:17813-17818.
33. Viennois E., Mouzat K., Dufour J., Morel L., Lobaccaro J.M., Baron S. Selective liver X receptor modulators (SLiMs): what use in human health?. Mol Cell Endocrinol 2012, 351:129-141.
34. Viennois E., Pommier A.J., Mouzat K., Oumeddour A., El Hajjaji F.Z., Dufour J., et al. Targeting liver X receptors in human health: deadlock or promising trail?. Expert Opin Ther Targets 2011, 15:219-232.
35. Wang D., Liu M., Wang Y., Luo M., Wang J., Dai C., et al. Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats. Int Immunopharmacol 2011, 11:2098-2103.
36. Wu S., Yin R., Ernest R., Li Y., Zhelyabovska O., Luo J., et al. Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling. Cardiovasc Res 2009, 84:119-126.
37. Younce C.W., Burmeister M.A., Ayala J.E. Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. Am J Physiol Cell Physiol 2013, 304:C508-C518.
38. Zelcer N., Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 2006, 116:607-614.
39. Zhou S., Wu H., Zeng C., Xiong X., Tang S., Tang Z., et al. Apolipoprotein E protects astrocytes from hypoxia and glutamate-induced apoptosis. FEBS Lett 2013, 587:254-258.
40. Zou H., Li Y., Liu X., Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 1999, 274:11549-11556.