Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men

Clinical Epigenetics

Volumn 5, Issue 1, 2013, Pages

  Gu, Tianwei ^a   Gu, Harvest F ^a   Hilding, Agneta ^a   Sjöholm, Louise K ^a   Östenson, Claes Göran ^a   Ekström, Tomas J ^a   Brismar, Kerstin ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

DNA methylation; IGFBP 1; Type 2 diabetes

Indexed keywords

GENOMIC DNA; INSULIN; ORAL ANTIDIABETIC AGENT; SOMATOMEDIN BINDING PROTEIN 1;

ADULT; ARTICLE; BODY MASS; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; DIET THERAPY; DISEASE DURATION; DNA METHYLATION; EPIGENETICS; ETHNIC GROUP; EXERCISE; FAMILY HISTORY; GENETIC ASSOCIATION; HUMAN; IGFBP1 GENE; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PYROSEQUENCING; RADIOIMMUNOASSAY; SWEDISH; WAIST CIRCUMFERENCE;

EID: 84894820674     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/1868-7083-5-21     Document Type: Article

References (28)

1. Billings LK, Florez JC: The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci (2010), 1212:59-77.
2. Ahlqvist E, Ahluwalia TS, Groop L: Genetics of type 2 diabetes. Clin Chem (2011), 57(2):241-254.
3. Imamura M, Maeda S: Genetics of type 2 diabetes: the GWAS era and future perspectives. Endocr J (2011), 58(9):723-739.
4. Ling C, Groop L: Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes (2009), 58(12):2718-2725.
5. Drong AW, Lindgren CM, McCarthy MI: The genetic and epigenetic basis of type 2 diabetes and obesity. Clin Pharmacol Ther (2012), 92(6):707-715
6. Kirchner H, Osler ME, Krook A, Zierath JR: Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol (2013), 23(5):203-209.
7. Suikkari AM, Koivisto VA, Koistinen R, Seppälä M, Yki-Järvinen H: Dose-response characteristics for suppression of low molecular weight plasma insulin-like growth factor-binding protein by insulin. J Clin EndocrinolMetab (1989), 68(1):135-140. (Pubitemid 19028736)
8. Brismar K, Fernqvist-Forbes E, Wahren J, Hall K: Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. J Clin Endocrinol Metab (1994), 79(3):872-878.
9. Petersson U, Ostgren CJ, Brudin L, Brismar K, Nilsson PM: Low levels of insulin-like growth-factor-binding protein-1 (IGFBP-1) are prospectively associated with the incidence of type 2 diabetes and impaired glucose tolerance (IGT): the Söderåkra cardiovascular risk factor study. Diabetes Metab (2009), 35(3):198-205.
10. Rajpathak SN, Gunter MJ, Wylie-Rosett J, Ho GY, Kaplan RC, Muzumdar R, Rohan TE, Strickler HD: The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes. Diabetes Metab Res Rev (2009), 25(1):3-12.
11. Gokulakrishnan K, Velmurugan K, Ganesan S, Mohan V: Circulating levels of insulin-like growth factor binding protein-1 in relation to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome (Chennai urban rural epidemiology study 118). Metabolism (2012), 61(1):43 -46.
12. Hong Y, Brismar K, Hall K, Pedersen NL, de Faire U: Associations between insulin-like growth factor-I (IGF-I), IGF-binding protein-1, insulin and other metabolic measures after controlling for genetic influences: results from middle-aged and elderly monozygotic twins. J Endocrinol (1997), 153(2):251-257. (Pubitemid 27219457)
13. Lewitt MS, Hilding A, Ostenson CG, Efendic S, Brismar K, Hall K: Insulin-like growth factor-binding protein-1 in the prediction and development of type 2 diabetes in middle-aged Swedish men. Diabetologia (2008), 51(7):1135-1145.
14. Lewitt MS, Hilding A, Brismar K, Efendic S, Ostenson CG, Hall K: IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women. Eur J Endocrinol (2010), 163(2):233- 242.
15. Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR: Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009), 462(7271):315-322.
16. Murrell A, Rakyan VK, Beck S: From genome to epigenome. Hum Mol Genet (2005), S1:R3-R10. (Pubitemid 40542614)
17. Schumacher A, Petronis A: Epigenetics of complex diseases: from general theory to laboratory experiments. Curr Top Microbiol Immunol (2006), 310:81-115. (Pubitemid 47400287)
18. Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR: Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab (2012), 15(3):405-411.
19. Yin H, Blanchard KL: DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms. Blood (2000), 95(1):111-119. (Pubitemid 30017233)
20. Rehman JU, Brismar K, Holmbäck U, Akerstedt T, Axelsson J: Sleeping during the day: effects on the 24-h patterns of IGF-binding protein 1, insulin, glucose, cortisol, and growth hormone. Eur J Endocrinol (2010), 163(3):383-390.
21. Humphriss DB, Stewart MW, Berrish TS, Barriocanal LA, Trajano LR, Ashworth LA, Brown MD, Miller M, Avery PJ, Alberti KG, Walker M: Multiple metabolic abnormalities in normal glucose tolerant relatives of NIDDM families. Diabetologia (1997), 40(10):1185-1190.
22. Eriksson AK, Ekbom A, Granath F, Hilding A, Efendic S, Ostenson CG: Psychological distress and risk of pre-diabetes and type 2 diabetes in a prospective study of Swedish middle-aged men and women. Diabet Med (2008), 25(7):834-842.
23. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications: part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med (1998), 15(7):539-553. (Pubitemid 28319935)
24. Tost J, Dunker J, Gut IG: Analysis and quantification of multiple methylation variable positions in CpG islands by pyrosequencing. BioTechniques (2003), 35(1):152-156. (Pubitemid 36828725)
25. Colella S, Shen L, Baggerly KA, Issa JP, Krahe R: Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites. BioTechniques (2003), 35(1):146-150. (Pubitemid 36828724)
26. Póvoa G, Roovete A, Hall K: Cross-reaction of serum somatomedin-binding protein in a radioimmunoassay developed for somatomedin-binding protein isolated from human amniotic fluid. Acta Endocrinol (Copenh) (1984), 107(4):563-570 (Pubitemid 15216173)
27. Grill V, Pigon J, Hartling SG, Binder C, Efendic S: Effects of dexamethasone on glucose-induced insulin and proinsulin release in low and high insulin responders. Metabolism (1990), 39(3):251-258. (Pubitemid 20086104)
28. Bang P, Eriksson U, Sara V, Wivall IL, Hall K: Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinol (Copenh) (1991), 124(6):620-629.