Protein Effects on Surfactant Adsorption Suggest the Dominant Mode of Surfactant-Mediated Stabilization of Protein

Journal of Pharmaceutical Sciences

Volumn 103, Issue 5, 2014, Pages 1337-1345

  Kim, Hyojin Lee ^a,b   Mcauley, Arnold ^b   Mcguire, Joseph ^a  

^a Oregon State University   (United States)

^b AMGEN INC   (United States)

Author keywords

adsorption; kinetics; poloxamer; polysorbate; protein stabilization mechanism; proteins; surface tension kinetics; surfactants; thermodynamics

Indexed keywords

LYSOZYME; POLOXAMER; POLYSORBATE 20; POLYSORBATE 80; RECOMBINANT PROTEIN; SURFACTANT; POLYSORBATE;

ADSORPTION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENTHALPY; ENTROPY; HUMAN; PROTEIN AGGREGATION; PROTEIN STABILITY; PROTEIN STRUCTURE; RATE CONSTANT; ROOM TEMPERATURE; SURFACE PROPERTY; SURFACE TENSION; CHEMISTRY; KINETICS; THERMODYNAMICS;

ADSORPTION; KINETICS; POLOXAMER; POLYSORBATES; RECOMBINANT PROTEINS; SURFACE TENSION; SURFACE-ACTIVE AGENTS; THERMODYNAMICS;

EID: 84894684645     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23908     Document Type: Article

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