Polysorbate 80 and Cremophor EL micelles deaggregate and solubilize nystatin at the core-corona interface

Journal of Pharmaceutical Sciences

Volumn 94, Issue 11, 2005, Pages 2345-2354

  Croy, Scott R ^a   Kwon, Glen S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Adsorption; Aggregation; Cremophor EL; Micelles; Nystatin; Particle size; Polysorbate 80; Solubility; Surfactants

Indexed keywords

CREMOPHOR; NONIONIC SURFACTANT; NYSTATIN; PHOSPHATE BUFFERED SALINE; POLYSORBATE 80; PYRENE; WATER;

ADSORPTION; ARTICLE; DRUG SOLUBILITY; DYNAMICS; FLUORESCENCE; LIGHT SCATTERING; MICELLE; PARTITION COEFFICIENT;

EID: 30544441982     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20301     Document Type: Article

References (26)

1. Jonkman-de Vries JD, Flora KP, Bult A, Beijnen JH. 1996. Pharmaceutical development of (investigational) anticancer agents for parenteral use: A review. Drug Dev Ind Pharm 22:475-494.
2. Inactive ingredient search for approved drug products, "polysorbate 80" and "polyoxyl 35 castor oil." United States Food and Drug Administration, 2004 (8 December), http://www.accessdata.fda.gov/ scripts/cder/iig/index.cfm.
3. Adams ML, Lavasanifar A, Kwon GS. 2003. Amphiphilic block copolymers for drug delivery. J Pharm Sci 92:1343-1355.
4. Tije AJ, Verweij J, Loos WJ, Sparreboom A. 2003. Pharmacological effects of formulation vehicles: Implications for cancer chemotherapy. Clin Pharmacokinet 42:665-685.
5. Gunderson SM, Hoffman H, Ernst EJ, Pfaller MA, Klepser ME. 2000. In vitro pharmacodynamic characteristics of nystatin including time-kill and postantifungal effect. Antimicrob Agents Chemother 44:2887-2890.
6. Bolard J, Legrand P, Heitz F, Cybulska B. 1991. One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium. Biochemistry 30:5707-5715.
7. Coutinho A, Prieto M. 1995. Self-association of the polyene antibiotic nystatin in dipalmitoylphosphatidylcholine vesicles: A time-resolved fluorescence study. Biophys J 69:2541-2557.
8. Johnson EM, Ojwang JO, Szekely A, Wallace TL, Warnock DW. 1998. Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations. Antimicrob Agents Chemother 42:1412-1416.
9. Denning DW, Warn P. 1999. Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B. Antimicrob Agents Chemother 43:2592-2599.
10. Pfaller MA, Jones RN, Messer SA, Edmond MB, Wenzel RP. 1998. National surveillance of nosocomial blood stream infection due to Candida albicans: Frequency of occurrence and antifungal susceptibility in the SCOPE program. Diagn Microbiol Infect Dis 31:327-332.
11. Castanho MARB, Coutinho A, Prieto MJE. 1992. Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol. J Biol Chem 267:204-209.
12. Croy SR, Kwon GS. 2004. The effects of pluronic block copolymers on the aggregation state of nystatin. J Controlled Release 95:161-171.
13. Wilhelm M, Zhao C, Wang Y, Xu R, Winnik MA, Mura J, Riess G, Croucher MD. 1991. Poly(styrene-ethylene oxide) block copolymer micelle formation in water: A fluorescence probe study. Macromolecules 24:1033-1040.
14. Kalyanasundaram K, Thomas JK. 1977. Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems. J Am Chem Soc 99:2039-2044.
15. Dong DC, Winnik MA. 1984. The Py scale of solvent polarities. Can J Chem 62:2560-2565.
16. Kozlov MY, Melik-Nubarov NS, Batrakova EV, Kabanov AV. 2000. Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes. Macromolecules 33:3305-3313.
17. Kabanov AV, Nazarova IR, Astafieva IV, Batrakova EV, Alakhov VY, Yaroslavov AA, Kabanov VA. 1995. Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions. Macromolecules 28:2303-2314.
18. Sun SF, Serpentino PM. 1974. The determination of partial specific volume. J Chem Educ 51:552-553.
19. Mukerjee P, Ko J. 1992. Solubilization of ethyl o-, m-, and p-aminobenzoates in micelles of different charge types: Interfacial adsorption and orientation effects. J Phys Chem 96:6090-6094.
20. Gonzalez M, Vera J, Abuin EB, Lissi EA. 1984. Solubilization of naphthalene derivatives in micellar assemblies. J Colloid Interface Sci 98:152-161.
21. Patel NK, Kostenbauder HB. 1958. Interaction of preservatives with macromolecules I. Binding of parahydroxybenzoic acid esters by polyoxyethylene 20 sorbitan monooleate (Tween 80). J Am Pharm Assoc 47:289-293.
22. Dougherty SJ, Berg JC. 1974. Distribution equilibria in micellar solutions. J Colloid Interface Sci 48:110-121.
23. Donbrow M, Rhodes CT. 1964. Potentiometric studies on solubilization in non-ionic micellar solutions. Part I. Interpretation of pH changes and mechanism of solubilization of benzoic acid. J Chem Soc Suppl:6166-6171.
24. Donbrow M, Molyneux P, Rhodes CT. 1967. Potentiometric studies on solubilization in non-ionic micellar solutions. Part II. Solubilization of benzoic acid and the hydroxybenzoic acids and location of the solubilizates. J Chem Soc A 4:561-565.
25. Choucair A, Eisenberg A. 2003. Interfacial solubilization of model amphiphilic molecules in block copolymer micelles. J Am Chem Soc 125:11993-12000.
26. Crittenden B, Thomas WJ. 1998. Adsorption technology & design. Oxford: Butterworth-Heinemann, pp 31-65.