A meta-analysis of the relation of intolerance of uncertainty to symptoms of generalized anxiety disorder, major depressive disorder, and obsessive-compulsive disorder

Clinical Psychology Review

Volumn 31, Issue 6, 2011, Pages 923-933

  Gentes, Emily L ^a   Ruscio, Ayelet Meron ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Generalized anxiety disorder; Intolerance of uncertainty; Major depressive disorder; Obsessive compulsive disorder

Indexed keywords

ASSOCIATION; BEHAVIORAL STRESS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; EMOTION; GENERALIZED ANXIETY DISORDER; HUMAN; MAJOR DEPRESSION; MATHEMATICAL MODEL; MEDICAL RESEARCH; META ANALYSIS; OBSESSIVE COMPULSIVE DISORDER; POST HOC ANALYSIS; QUESTIONNAIRE; RATING SCALE; REVIEW; STATISTICAL ANALYSIS; SYMPTOM; UNCERTAINTY;

ANXIETY DISORDERS; DEPRESSIVE DISORDER, MAJOR; HUMANS; OBSESSIVE-COMPULSIVE DISORDER; UNCERTAINTY;

EID: 79958067832     PISSN: 02727358     EISSN: 18737811     Source Type: Journal    
DOI: 10.1016/j.cpr.2011.05.001     Document Type: Review

References (82)

1. *Abramowitz J.S., Deacon B.J. Psychometric properties and construct validity of the Obsessive-Compulsive Inventory-Revised: Replication and extension with a clinical sample. Journal of Anxiety Disorders 2006, 20:1016-1035.
2. *Abramowitz J.S., Wheaton M.G., Storch E.A. The status of hoarding as a symptom of obsessive-compulsive disorder. Behaviour Research and Therapy 2008, 46:1026-1033.
3. *Anholt G.E., Emmelkamp P.M.G., Cath D.C., van Oppen P., Nelissen H., Smit J.H. Do patients with OCD and pathological gambling have similar dysfunctional cognitions?. Behaviour Research and Therapy 2004, 42:529-537.
4. *Berenbaum H., Bredemeier K., Thompson R.J. Intolerance of uncertainty: Exploring its dimensionality and associations with need for cognitive closure, psychopathology, and personality. Journal of Anxiety Disorders 2008, 22:117-125.
5. *Boelen P.A., Reijntjes A. Intolerance of uncertainty and social anxiety. Journal of Anxiety Disorders 2009, 23:130-135.
6. Borenstein M., Hedges L., Higgins J., Rothstein H. Comprehensive Meta-analysis version 2 2005, Englewood NJ, Biostat.
7. Brown T.A., Barlow D.H. A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: Implications for assessment and treatment. Psychological Assessment 2009, 21:256-271.
8. *Buhr K., Dugas M.J. The Intolerance of Uncertainty Scale: Psychometric properties of the English version. Behaviour Research and Therapy 2002, 40:931-946.
9. Buhr K., Dugas M.J. Investigating the construct validity of intolerance of uncertainty and its unique relationship with worry. Journal of Anxiety Disorders 2006, 20:222-236.
10. Buhr K., Dugas M.J. The role of fear of anxiety and intolerance of uncertainty in worry: An experimental manipulation. Behaviour Research and Therapy 2009, 47:215-223.
11. *Butzer B., Kuiper N.A. Relationships between the frequency of social comparisons and self-concept clarity, intolerance of uncertainty, anxiety, and depression. Personality and Individual Differences 2006, 41:167-176.
12. *Calamari J.E., Rector N.A., Woodard J.L., Cohen R.J., Chik H.M. Anxiety sensitivity and obsessive-compulsive disorder. Assessment 2008, 15:351-363.
13. Carleton R.N., Gosselin P., Asmundsen G.J. The Intolerance of Uncertainty Index: Replication and extension with an English sample. Psychological Assessment 2010, 22:396-406.
14. *Carleton R.N., Norton M.A.P.J., Asmundson G.J.G. Fearing the unknown: A short version of the Intolerance of Uncertainty Scale. Journal of Anxiety Disorders 2007, 21:105-117.
15. Clark D.A. A cognitive perspective on obsessive compulsive disorder and depression: Distinct and related features. Cognitive approaches to obsessions and compulsions - Theory, assessment, and treatment 2002, Elsevier Science, New York, NY. R.O. Frost, G. Steketee (Eds.).
16. Cohen J. A power primer. Psychological Bulletin 1992, 112:155-159.
17. *Coles M.E., Horng B. A prospective test of cognitive vulnerability to obsessive-compulsive disorder. Cognitive Therapy and Research 2006, 30:723-734.
18. *Crittendon J., Hopko D.R. Assessing worry in older and younger adults: Psychometric properties of an abbreviated Penn State Worry Questionnaire (PSWQ-A). Journal of Anxiety Disorders 2006, 20:1036-1054.
19. Deacon B., Abramowitz J. Is hypochondriasis related to obsessive compulsive disorder, panic disorder, or both? An empirical evaluation. Journal of Cognitive Psychotherapy 2008, 22:115-127.
20. Deacon, B., Abramowitz, J., & Maack, D. J. (2010). Intolerance of uncertainty and the anxiety disorders. Unpublished manuscript.
21. *Dugas M.J., Freeston M.H., Ladouceur R. Intolerance of uncertainty and problem orientation in worry. Cognitive Therapy and Research 1997, 21:593-606.
22. *Dugas M.J., Gosselin P., Ladouceur R. Intolerance of uncertainty and worry: Investigating specificity in a nonclinical sample. Cognitive Therapy and Research 2001, 25:551-558.
23. *Dugas M.J., Hedayati M., Karavidas A., Buhr K., Francis K., Phillips N.A. Intolerance of uncertainty and information processing: Evidence of biased recall and interpretations. Cognitive Therapy and Research 2005, 29:57-70.
24. Dugas M.J., Ladouceur R., Boisvert J., Freeston M.H. Generalized anxiety disorder: Fundamental elements and psychological interventions. Canadian Psychology 1996, 37:40-53.
25. Dugas M.J., Savard P., Gaudet A., Turcotte J., Laugesen N., Robichaud M., et al. Can the components of a cognitive model predict the severity of generalized anxiety disorder?. Behavior Therapy 2007, 38:169-178.
26. *Dugas M.J., Schwartz A., Francis K. Intolerance of uncertainty, worry, and depression. Cognitive Therapy and Research 2004, 28:835-842.
27. Dupuy J., Ladouceur R. Cognitive processes of generalized anxiety disorder in comorbid generalized anxiety disorder and major depressive disorder. Journal of Anxiety Disorders 2008, 22:505-514.
28. *Fergus T.A., Wu K.D. Do symptoms of generalized anxiety and obsessive-compulsive disorder share cognitive processes?. Cognitive Therapy and Research 2010, 34:168-176.
29. *Freeston M.H., Rhéaume J., Letarte H., Dugas M.J., Ladouceur R. Why do people worry?. Personality and Individual Differences 1994, 17:791-802.
30. Frenkel-Brunswik E. Intolerance of ambiguity as an emotional and perceptual personality variable. Journal of Personality 1949, 18:108-143.
31. Garber J., Hollon S.D. What can specificity designs say about causality in psychopathology research?. Psychological Bulletin 1991, 110:129-136.
32. Gentes, E. L. & Ruscio, A. M. (2008). [Intolerance of uncertainty in generalized anxiety disorder and major depressive disorder]. Unpublished raw data.
33. Gentes, E. L. & Ruscio, A. M. (2010). [Intolerance of uncertainty in generalized anxiety disorder and major depressive disorder]. Unpublished raw data.
34. *Gosselin P., Ladouceur R., Evers A., Laverdière A., Routhier S., Tremblay-Picard M. Evaluation of intolerance of uncertainty: Development and validation of a new self-report measure. Journal of Anxiety Disorders 2008, 22:1427-1439.
35. Grant B.F., Hasin D.S., Stinson F.S., Dawson D.A., Ruan W.J., Goldstein R.B., et al. Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences 2005, 35:1747-1759.
36. Grayson J. Freedom from obsessive compulsive disorder: A personalized recovery program for living with uncertainty 2004, Berkley Publishing Group, New York, NY.
37. Grenier S., Barrette A., Ladouceur R. Intolerance of uncertainty and intolerance of ambiguity: Similarities and differences. Personality and Individual Differences 2005, 39:593-600.
38. Hammen C.L., Cochran S.D. Cognitive correlates of life stress and depression in college students. Journal of Abnormal Psychology 1981, 90:23-27.
39. Harvey A.E., Watkins E., Mansell W., Shafran R. Cognitive behavioural processes across psychological disorders: A transdiagnostic approach to research and treatment 2004, Oxford, New York, NY.
40. Hedges L.V., Olkin I. Statistical methods for meta-analysis 1985, Academic Press, Orlando FL.
41. Higgins J.P., Thompson S.G., Deeks J.J., Altman D.G. Measuring inconsistency in meta-analysis. British Medical Journal 2003, 327:557-560.
42. *Holaway R.M., Heimberg R.G., Coles M.E. A comparison of intolerance of uncertainty in analogue obsessive-compulsive disorder and generalized anxiety disorder. Journal of Anxiety Disorders 2006, 20:158-174.
43. Hong, R. Y. (2008). Personality vulnerabilities to psychopathology: Exploration of relations between trait structure and social-cognitive processes. (Unpublished doctoral dissertation). University of Western Ontario, Western Ontario, Canada.
44. Huffcut A.I., Arthur W. Development of a new outlier statistic for meta-analytic data. Journal of Consulting and Clinical Psychology 1995, 74:401-415.
45. *Julien D., Careau Y., O'Connor K.P., Bouvard M., Rhéaume J., Langlois F., et al. Specificity of belief domains in OCD: Validation of the French version of the Obsessive Beliefs Questionnaire and a comparison across samples. Journal of Anxiety Disorders 2008, 22:1029-1041.
46. Keenan-Smith, J. (2007). Issues in PTSD assessment: Exploring intolerance of uncertainty and field dependence among PTSD veterans. (Unpublished doctoral dissertation). Long Island University, Long Island, NY.
47. Koerner-Singh, N. (2007). Cognitive vulnerability to excessive worry and its relationship to the processing of uncertainty. (Unpublished doctoral dissertation). Concordia University, Montreal, Canada.
48. *Ladouceur R., Blais F., Freeston M.H., Dugas M.J. Problem solving and problem orientation in generalized anxiety disorder. Journal of Anxiety Disorders 1998, 12:139-152.
49. Ladouceur R., Dugas M.J., Freeston M.H., Leger E., Gagnon F., Thibodeau N. Efficacy of a cognitive behavioral treatment for generalized anxiety disorder: Evaluation in a controlled clinical trial. Journal of Consulting and Clinical Psychology 2000, 68:957-964.
50. *Ladouceur R., Dugas M.J., Freeston M.H., Rhéaume J., Blais F., Boisvert J., et al. Specificity of generalized anxiety disorder symptoms and processes. Behavior Therapy 1999, 30:191-207.
51. Ladouceur R., Talbot F., Dugas M.J. Behavioral expressions of intolerance of uncertainty in worry. Behavior Modification 1997, 21:355-371.
52. *Lind C., Boschen M.J. Intolerance of uncertainty mediates the relationship between responsibility beliefs and compulsive checking. Journal of Anxiety Disorders 2009, 23:1047-1052.
53. Lipsey M.W., Wilson D.B. Practical meta-analysis 2001, Sage Publications, Inc., Thousand Oaks, CA.
54. McFall M.E., Wollersheim J.P. Obsessive-compulsive neurosis: A cognitive-behavioral formulation and approach to treatment. Cognitive Therapy and Research 1979, 3:333-348.
55. *Miranda R., Fontes M., Marroquín B. Cognitive content-specificity in future expectancies: Role of hopelessness and intolerance of uncertainty in depression and GAD symptoms. Behaviour Research and Therapy 2008, 46:1151-1159.
56. *Myers S.G., Fisher P.L., Wells A. Belief domains of the Obsessive Beliefs Questionnaire-44 (OBQ-44) and their specific relationship with obsessive-compulsive symptoms. Journal of Anxiety Disorders 2008, 22:475-484.
57. Naragon-Gainey K. Meta-analysis of the relations of anxiety sensitivity to the depressive and anxiety disorders. Psychological Bulletin 2010, 136:128-150.
58. Norton P.J., Mehta P.D. Hierarchical model of vulnerabilities for emotional disorders. Cognitive Behaviour Therapy 2007, 36:240-254.
59. *Norton P.J., Sexton K.A., Walker J.R., Norton G.R. Hierarchical model of vulnerabilities for anxiety: Replication and extension with a clinical sample. Cognitive Behaviour Therapy 2005, 34:50-63.
60. *Obsessive Compulsive Cognitions Working Group Psychometric validation of the Obsessive Beliefs Questionnaire and the Interpretation of Intrusions Inventory: Part I. Behaviour Research and Therapy 2003, 41:863-878.
61. *Obsessive Compulsive Cognitions Working Group Psychometric validation of the obsessive belief questionnaire and interpretation of intrusions inventory-Part 2: Factor analyses and testing of a brief version. Behaviour Research and Therapy 2005, 43:1527-1542.
62. *Olatunji B.O., Broman-Fulks J.J., Bergman S.M., Green B.A., Zlomke K.R. A taxometric investigation of the latent structure of worry: Dimensionality and associations with depression, anxiety, and stress. Behavior Therapy 2009, Advance online publication. 10.1016/j.beth.2009.03.001.
63. Orwin R.G. A fail-safe N for effect size in meta-analysis. Journal of Educational Statistics 1983, 8:157-159.
64. *Radomsky A.S., Ashbaugh A.R., Gelfand L.A. Relationships between anger, symptoms, and cognitive factors in OCD checkers. Behaviour Research and Therapy 2007, 45:2712-2725.
65. *Rassin E., Muris P. Indecisiveness and the interpretation of ambiguous situations. Personality and Individual Differences 2005, 39:1285-1291.
66. *Rector N.A., Cassin S.E., Richter M.A., Burroughs E. Obsessive beliefs in first-degree relatives of patients with OCD: A test of the cognitive vulnerability model. Journal of Anxiety Disorders 2009, 23:145-149.
67. *Riskind J.H., Tzur D., Williams N.L., Mann B., Shahar G. Short-term predictive effects of the looming cognitive style on anxiety disorder symptoms under restrictive methodological conditions. Behaviour Research and Therapy 2007, 45:1765-1777.
68. Rosenthal R. Meta-analytic procedures for social research 1991, Sage, Newbury Park, CA.
69. Rucker, L. S. (2005). Correlates of worry and generalized anxiety disorder in Black/African Americans. (Unpublished doctoral dissertation). University of Massachusetts Boston, Boston, MA, US.
70. Ruscio A.M. Delimiting the boundaries of generalized anxiety disorder: Differentiating high worriers with and without GAD. Journal of Anxiety Disorders 2002, 16:377-400.
71. Ruscio, A. M. (2010). [Intolerance of uncertainty in generalized anxiety disorder and major depressive disorder]. Unpublished raw data.
72. Ruscio A.M., Seitchik A.E. Problem-solving abilities and appraisals associated with severe worry and GAD. Cognitive vulnerabilities in generalized anxiety disorder: Basic research findings and implications for practice. Symposium presented at the annual meeting of the Association for Behavioral and Cognitive Therapies, Philadelphia, PA 2007, November, A.M. Ruscio (Ed.).
73. *Sexton K.A., Norton P.J., Walker J.R., Norton G.R. Hierarchical model of generalized and specific vulnerabilities in anxiety. Cognitive Behaviour Therapy 2003, 32:82-94.
74. *Sica C., Coradeschi D., Sanavio E., Dorz S., Manchisi D., Novara C. A study of the psychometric properties of the obsessive beliefs inventory and interpretations of intrusions inventory on clinical Italian individuals. Journal of Anxiety Disorders 2004, 18:291-307.
75. Steketee G., Frost R., Amir N., Bouvard M., Carmin C., Clark D., et al. Cognitive assessment of obsessive-compulsive disorder. Behaviour Research and Therapy 1997, 35:667-681.
76. *Steketee G., Frost R.O., Cohen I. Beliefs in obsessive-compulsive disorder. Journal of Anxiety Disorders 1998, 12:525-537.
77. *Tolin D.F., Abramowitz J.S., Brigidi B.D., Foa E.B. Intolerance of uncertainty in obsessive-compulsive disorder. Journal of Anxiety Disorders 2003, 17:233-242.
78. *Tolin D.F., Brady R.E., Hannan S. Obsessional beliefs and symptoms of obsessive-compulsive disorder in a clinical sample. Journal of Psychopathology and Behavioral Assessment 2008, 30:31-42.
79. *Tolin D.F., Worhunsky P., Maltby N. Are 'obsessive' beliefs specific to OCD?: A comparison across anxiety disorders. Behaviour Research and Therapy 2006, 44:469-480.
80. *van der Heiden C., Melchior K., Muris P., Bouwmeester S., Bos A.E.R., van der Molen H.T. A hierarchical model for the relationships between general and specific vulnerability factors and symptom levels of generalized anxiety disorder. Journal of Anxiety Disorders 2010, 24:284-289.
81. *Wu K.D., Aardema F., O'Connor K.P. Inferential confusion, obsessive beliefs, and obsessive-compulsive symptoms: A replication and extension. Journal of Anxiety Disorders 2009, 23:746-752.
82. *Yook K., Kim K., Suh S.Y., Lee K.S. Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. Journal of Anxiety Disorders 2010, 24:623-628.