The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester

Archives of Toxicology

Volumn 88, Issue 3, 2014, Pages 815-821

  Bendadani, Carolin ^a   Meinl, Walter ^a   Monien, Bernhard H ^a   Dobbernack, Gisela ^a,b   Glatt, Hansruedi ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b PHARMALEX GMBH   (Germany)

Author keywords

Bioactivation; DNA adducts; Polycyclic aromatic hydrocarbon; Transgenic mice for human sulphotransferases

Indexed keywords

1-HYDROXYMETHYLPYRENE; 1-METHYLPYRENE; 1-SULFOOXYMETHYLPYRENE; ARYL SULFOTRANSFERASE; CARCINOGEN; DEOXYADENOSINE DERIVATIVE; DEOXYGUANOSINE; DNA ADDUCT; N(2)-(1-METHYLPYRENYL)-2'-DEOXYGUANOSINE; N(6)-(1-METHYLPYRENYL)-2'-DEOXYADENOSINE; PYRENE DERIVATIVE; SULFURIC ACID; SULT1A1 PROTEIN, HUMAN; SULT1A2 PROTEIN, HUMAN;

ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; DNA ADDUCT; DRUG INACTIVATION; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; RAT; TRANSGENIC MOUSE; WISTAR RAT;

ANIMALS; ARYLSULFOTRANSFERASE; CARCINOGENS; DEOXYADENOSINES; DEOXYGUANOSINE; DNA ADDUCTS; FEMALE; HUMANS; INACTIVATION, METABOLIC; MALE; MICE; MICE, TRANSGENIC; PYRENES; RATS; RATS, WISTAR; SULFURIC ACIDS;

EID: 84894587792     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1182-6     Document Type: Article

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