Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP 1 receptor antagonists for treatment of overactive bladder by core structure replacement

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 5, 2014, Pages 1327-1333

  Atobe, Masakazu ^a   Naganuma, Kenji ^a   Kawanishi, Masashi ^a   Morimoto, Akifumi ^a   Kasahara, Ken Ichi ^a   Ohashi, Shigeki ^a   Suzuki, Hiroko ^a   Hayashi, Takahiko ^a   Miyoshi, Shiro ^a  

^a ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

Cystometry; Indazole; Overactive bladder; Thiazole

Indexed keywords

INDAZOLE DERIVATIVE; PHENYL GROUP; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 1 ANTAGONIST; PYRAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BLADDER CAPACITY; CYSTOMETRY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; MICTURITION; NONHUMAN; OVERACTIVE BLADDER; RAT; STRUCTURE ACTIVITY RELATION; URINE VOLUME;

RATTUS;

CYSTOMETRY; EP(1) ANTAGONIST; INDAZOLE; OVERACTIVE BLADDER; THIAZOLE;

ANIMALS; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; HUMANS; INDAZOLES; PROTEIN BINDING; RATS; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; URINARY BLADDER; URINARY BLADDER, OVERACTIVE;

EID: 84894574992     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.01.052     Document Type: Article

References (18)

1. A.J. Wein Urology 60 2002 7
2. O. Yamaguchi Clin. Drug Ther. 21 2002 2
3. K.E. Andersson Pharmacol. Rev. 45 1993 253
4. M.A. Khan, C.S. Thompson, F.H. Mumtaz, J.Y. Jeremy, R.J. Morgan, and D.P. Mikhailidis Prostaglandins Leukot. Essent. Fatty Acids 59 1998 415
5. S. Palea, G. Toson, C. Pietra, D.G. Trist, W. Artibani, O. Romano, and M. Corsi Br. J. Pharmacol. 124 1998 865
6. T. Miki, M. Matsunami, S. Nakamura, H. Okada, H. Matsuya, and A. Kawabata Pain 152 2011 1373
7. Okada, H.; Konemura, T.; Maruyama T. EAU Congress 2010, Poster Session 125.
8. Cima Science Journal, inc. New Current, 2013, 24, 40.
9. M. Atobe, K. Naganuma, M. Kawanishi, A. Morimoto, K. Kasahara, S. Ohashi, H. Suzuki, T. Hayashi, and S. Miyoshi Bioorg. Med. Chem. Lett. 23 2013 6064
10. M. Atobe, K. Naganuma, M. Kawanishi, A. Morimoto, K. Kasahara, S. Ohashi, H. Suzuki, T. Hayashi, and S. Miyoshi Bioorg. Med. Chem. Lett. 24 2013 6569
11. J.C. Antilla, J.M. Baskin, T.B. Barder, and S.L. Buchwald J. Org. Chem. 69 2004 5578
12. E.C. Taylor, and D.M. Sobieray Tetrahedron 47 1991 9599
13. J.G. Rodriguez, A. Lafuente, and P. Garcïa-Almaraz J. Heterocycl. Chem. 37 2000 1281
14. B.M. Lynch, M.A. Khan, H.C. Teo, and F. Pedrotti Can. J. Chem. 66 1988 420
15. D. Vina, E. Olmo, J.L. López-Pérez, and A. Feliciano Org. Lett. 9 2007 525
16. T.H. Stephen, and R.N. Swaminathan Org. Lett. 8 2006 2675
17. C. Valerie, V. Didier, and R. Sylvain Tetrahedron Lett. 41 2000 4363
18. L. Elodie, C. Valerie, S. Silvia, and R. Sylvain Synthesis 16 2011 2651