SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6569-6576

  Atobe, Masakazu ^a   Naganuma, Kenji ^a   Kawanishi, Masashi ^a   Morimoto, Akifumi ^a   Kasahara, Ken Ichi ^a   Ohashi, Shigeki ^a   Suzuki, Hiroko ^a   Hayashi, Takahiko ^a   Miyoshi, Shiro ^a  

^a ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

EP1 antagonist; Optimization; Pyrazole; Solubility; Thiazole

Indexed keywords

2 (1H PYRAZOL 1 YL)THIAZOLE DERIVATIVE; BROMINE; CHLORINE; FLUORINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG STRUCTURE; HYDROLYSIS; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MEMBRANE PERMEABILITY; OVERACTIVE BLADDER; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; SALMONELLA TYPHIMURIUM; STRUCTURE ACTIVITY RELATION;

EP1 ANTAGONIST; OPTIMIZATION; PYRAZOLE; SOLUBILITY; THIAZOLE;

HUMANS; PROTEIN BINDING; PYRAZOLES; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84888873001     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.065     Document Type: Article

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