Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 22, 2013, Pages 6064-6067

  Atobe, Masakazu ^a   Naganuma, Kenji ^a   Kawanishi, Masashi ^a   Morimoto, Akifumi ^a   Kasahara, Ken Ichi ^a   Ohashi, Shigeki ^a   Suzuki, Hiroko ^a   Hayashi, Takahiko ^a   Miyoshi, Shiro ^a  

^a ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

EP1 receptor antagonist; HTS; Overactive bladder; Pyrazole; Thiazole

Indexed keywords

2 (1H PYRAZOL 1 YL)THIAZOLE DERIVATIVE; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EP(1) RECEPTOR ANTAGONIST; HTS; OVERACTIVE BLADDER; PYRAZOLE; THIAZOLE;

ANIMALS; HUMANS; MICE; MODELS, MOLECULAR; PYRAZOLES; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84885951591     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.032     Document Type: Article

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