-
1
-
-
77954143522
-
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
-
1:CAS:528:DC%2BC3cXnvFykt70%3D 3080658 20581827 10.1038/ng.609
-
Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579-589
-
(2010)
Nat Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
-
2
-
-
84868337361
-
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
-
1:CAS:528:DC%2BC38XhtFOgsLfP 3442244 22885922 10.1038/ng.2383
-
Morris AP, Voight BF, Teslovich TM et al (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 44:981-990
-
(2012)
Nat Genet
, vol.44
, pp. 981-990
-
-
Morris, A.P.1
Voight, B.F.2
Teslovich, T.M.3
-
3
-
-
80051986265
-
Globalization of diabetes: The role of diet, lifestyle, and genes
-
21617109 10.2337/dc11-0442
-
Hu FB (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 34:1249-1257
-
(2011)
Diabetes Care
, vol.34
, pp. 1249-1257
-
-
Hu, F.B.1
-
4
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
1:CAS:528:DC%2BD38XhtVWqurc%3D 11832527 10.1056/NEJMoa012512
-
Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
Fowler, S.E.3
-
5
-
-
0345827813
-
The epidemiology of lifestyle and risk for type 2 diabetes
-
14758868
-
van Dam RM (2003) The epidemiology of lifestyle and risk for type 2 diabetes. Eur J Epidemiol 18:1115-1125
-
(2003)
Eur J Epidemiol
, vol.18
, pp. 1115-1125
-
-
Van Dam, R.M.1
-
6
-
-
30044439080
-
Epidemiologic and economic consequences of the global epidemics of obesity and diabetes
-
1:CAS:528:DC%2BD28Xht1KgtA%3D%3D 16397571 10.1038/nm0106-62
-
Yach D, Stuckler D, Brownell KD (2006) Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 12:62-66
-
(2006)
Nat Med
, vol.12
, pp. 62-66
-
-
Yach, D.1
Stuckler, D.2
Brownell, K.D.3
-
7
-
-
0035704552
-
The thrifty phenotype hypothesis
-
1:STN:280:DC%2BD38%2Fot12mug%3D%3D 11809615 10.1093/bmb/60.1.5
-
Hales CN, Barker DJ (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5-20
-
(2001)
Br Med Bull
, vol.60
, pp. 5-20
-
-
Hales, C.N.1
Barker, D.J.2
-
8
-
-
84880146957
-
Epigenetics of gestational diabetes mellitus and offspring health: The time for action is in early stages of life
-
23515667 10.1093/molehr/gat020
-
Lehnen H, Zechner U, Haaf T (2013) Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life. Mol Hum Reprod 19:415-422
-
(2013)
Mol Hum Reprod
, vol.19
, pp. 415-422
-
-
Lehnen, H.1
Zechner, U.2
Haaf, T.3
-
9
-
-
57749195712
-
RNA-Seq: A revolutionary tool for transcriptomics
-
1:CAS:528:DC%2BD1cXhsFWis7bL 2949280 19015660 10.1038/nrg2484
-
Wang Z, Gerstein M, Snyder M (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10:57-63
-
(2009)
Nat Rev Genet
, vol.10
, pp. 57-63
-
-
Wang, Z.1
Gerstein, M.2
Snyder, M.3
-
10
-
-
23744439083
-
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
-
1:CAS:528:DC%2BD2MXovV2qsrs%3D 16096055 10.1016/j.cell.2005.05.027
-
Gunton JE, Kulkarni RN, Yim S et al (2005) Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122:337-349
-
(2005)
Cell
, vol.122
, pp. 337-349
-
-
Gunton, J.E.1
Kulkarni, R.N.2
Yim, S.3
-
11
-
-
84881218353
-
Inactivation of specific beta cell transcription factors in type 2 diabetes
-
1:CAS:528:DC%2BC3sXht1OgtbvF 3726150 10.1172/JCI65390
-
Guo S, Dai C, Guo M et al (2013) Inactivation of specific beta cell transcription factors in type 2 diabetes. J Clin Invest 123:3305-3316
-
(2013)
J Clin Invest
, vol.123
, pp. 3305-3316
-
-
Guo, S.1
Dai, C.2
Guo, M.3
-
12
-
-
84859254586
-
The human pancreatic islet transcriptome: Expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
-
1:CAS:528:DC%2BC38XktF2htb0%3D 3297576 22412385 10.1371/journal.pgen. 1002552
-
Eizirik DL, Sammeth M, Bouckenooghe T et al (2012) The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet 8:e1002552
-
(2012)
PLoS Genet
, vol.8
, pp. 1002552
-
-
Eizirik, D.L.1
Sammeth, M.2
Bouckenooghe, T.3
-
13
-
-
24344459011
-
Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy
-
1:CAS:528:DC%2BD2MXhtVersb3K 15923354 10.1369/jhc.5C6684.2005
-
Brissova M, Fowler MJ, Nicholson WE et al (2005) Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 53:1087-1097
-
(2005)
J Histochem Cytochem
, vol.53
, pp. 1087-1097
-
-
Brissova, M.1
Fowler, M.J.2
Nicholson, W.E.3
-
14
-
-
84875684003
-
Islet beta cell mass in diabetes and how it relates to function, birth, and death
-
1:CAS:528:DC%2BC3sXnsVais7Y%3D 3618572 23363033 10.1111/nyas.12031
-
Weir GC, Bonner-Weir S (2013) Islet beta cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci 1281:92-105
-
(2013)
Ann N y Acad Sci
, vol.1281
, pp. 92-105
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
15
-
-
49149100973
-
Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers
-
1:CAS:528:DC%2BD1MXltFCitw%3D%3D 19383399 10.1016/j.scr.2008.04.001
-
Dorrell C, Abraham SL, Lanxon-Cookson KM, Canaday PS, Streeter PR, Grompe M (2008) Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. Stem Cell Res 1:183-194
-
(2008)
Stem Cell Res
, vol.1
, pp. 183-194
-
-
Dorrell, C.1
Abraham, S.L.2
Lanxon-Cookson, K.M.3
Canaday, P.S.4
Streeter, P.R.5
Grompe, M.6
-
16
-
-
80054682732
-
Transcriptomes of the major human pancreatic cell types
-
1:CAS:528:DC%2BC3MXht12js7bF 21882062 10.1007/s00125-011-2283-5
-
Dorrell C, Schug J, Lin CF et al (2011) Transcriptomes of the major human pancreatic cell types. Diabetologia 54:2832-2844
-
(2011)
Diabetologia
, vol.54
, pp. 2832-2844
-
-
Dorrell, C.1
Schug, J.2
Lin, C.F.3
-
17
-
-
33644765957
-
MafB: An activator of the glucagon gene expressed in developing islet alpha- and beta-cells
-
1:CAS:528:DC%2BD28XhsFajsr8%3D 16443760 10.2337/diabetes.55.02.06.db05- 0946
-
Artner I, Le Lay J, Hang Y et al (2006) MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes 55:297-304
-
(2006)
Diabetes
, vol.55
, pp. 297-304
-
-
Artner, I.1
Le Lay, J.2
Hang, Y.3
-
18
-
-
84874626174
-
Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
-
1:CAS:528:DC%2BC3sXjvVyht70%3D 3582140 23434589 10.1172/JCI66514
-
Bramswig NC, Everett LJ, Schug J et al (2013) Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming. J Clin Invest 123:1275-1284
-
(2013)
J Clin Invest
, vol.123
, pp. 1275-1284
-
-
Bramswig, N.C.1
Everett, L.J.2
Schug, J.3
-
19
-
-
77649086970
-
A map of open chromatin in human pancreatic islets
-
1:CAS:528:DC%2BC3cXht1yntrg%3D 2828505 20118932 10.1038/ng.530
-
Gaulton KJ, Nammo T, Pasquali L et al (2010) A map of open chromatin in human pancreatic islets. Nat Genet 42:255-259
-
(2010)
Nat Genet
, vol.42
, pp. 255-259
-
-
Gaulton, K.J.1
Nammo, T.2
Pasquali, L.3
-
20
-
-
33846596193
-
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
-
1:CAS:528:DC%2BD2sXpvFeqsA%3D%3D 17206141 10.1038/ng1960
-
Helgason A, Palsson S, Thorleifsson G et al (2007) Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39:218-225
-
(2007)
Nat Genet
, vol.39
, pp. 218-225
-
-
Helgason, A.1
Palsson, S.2
Thorleifsson, G.3
-
21
-
-
70349312354
-
ChIP-seq: Advantages and challenges of a maturing technology
-
1:CAS:528:DC%2BD1MXhtFCqurjO 3191340 19736561 10.1038/nrg2641
-
Park PJ (2009) ChIP-seq: advantages and challenges of a maturing technology. Nat Rev Genet 10:669-680
-
(2009)
Nat Rev Genet
, vol.10
, pp. 669-680
-
-
Park, P.J.1
-
22
-
-
77950661065
-
Genome-wide analysis of histone modifications in human pancreatic islets
-
1:CAS:528:DC%2BC3cXkvFKhtrY%3D 20181961 10.1101/gr.102038.109
-
Bhandare R, Schug J, Le Lay J et al (2010) Genome-wide analysis of histone modifications in human pancreatic islets. Genome Res 20:428-433
-
(2010)
Genome Res
, vol.20
, pp. 428-433
-
-
Bhandare, R.1
Schug, J.2
Le Lay, J.3
-
23
-
-
78049446282
-
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
-
1:CAS:528:DC%2BC3cXhtlKhtbzL 3026436 21035756 10.1016/j.cmet.2010.09.012
-
Stitzel ML, Sethupathy P, Pearson DS et al (2010) Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab 12:443-455
-
(2010)
Cell Metab
, vol.12
, pp. 443-455
-
-
Stitzel, M.L.1
Sethupathy, P.2
Pearson, D.S.3
-
24
-
-
84860410786
-
Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression
-
1:CAS:528:DC%2BC3MXhtFaisLrI 21852533 10.1101/gad.16875711
-
Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV (2011) Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression. Genes Dev 25:1680-1685
-
(2011)
Genes Dev
, vol.25
, pp. 1680-1685
-
-
Yang, Y.P.1
Thorel, F.2
Boyer, D.F.3
Herrera, P.L.4
Wright, C.V.5
-
25
-
-
77951611220
-
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
-
1:CAS:528:DC%2BC3cXkt1aqtLc%3D 2877635 20364121 10.1038/nature08894
-
Thorel F, Nepote V, Avril I et al (2010) Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464:1149-1154
-
(2010)
Nature
, vol.464
, pp. 1149-1154
-
-
Thorel, F.1
Nepote, V.2
Avril, I.3
-
26
-
-
68149162957
-
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
-
1:CAS:528:DC%2BD1MXhsVChs7nO 2792203 19665969 10.1016/j.cell.2009.05.035
-
Collombat P, Xu X, Ravassard P et al (2009) The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 138:449-462
-
(2009)
Cell
, vol.138
, pp. 449-462
-
-
Collombat, P.1
Xu, X.2
Ravassard, P.3
-
27
-
-
84863334811
-
Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes
-
1:CAS:528:DC%2BC38XhtVegsrzI 22570331 10.1210/me.2012-1004
-
Yang BT, Dayeh TA, Volkov PA et al (2012) Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol 26:1203-1212
-
(2012)
Mol Endocrinol
, vol.26
, pp. 1203-1212
-
-
Yang, B.T.1
Dayeh, T.A.2
Volkov, P.A.3
-
28
-
-
84858800629
-
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
-
1:CAS:528:DC%2BC38XhtVKisLg%3D 22293752 10.1038/emboj.2011.503
-
Volkmar M, Dedeurwaerder S, Cunha DA et al (2012) DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 31:1405-1426
-
(2012)
EMBO J
, vol.31
, pp. 1405-1426
-
-
Volkmar, M.1
Dedeurwaerder, S.2
Cunha, D.A.3
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